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ZN211_HUMAN
ID   ZN211_HUMAN             Reviewed;         564 AA.
AC   Q13398; B4DH10; B4DLC9; B4E3C9; B9ZVS7; B9ZVW1; F8WDV2; Q05BQ7; Q2TAL7;
AC   Q59EG4; Q59G36; Q5EBL6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 181.
DE   RecName: Full=Zinc finger protein 211;
DE   AltName: Full=Zinc finger protein C2H2-25;
GN   Name=ZNF211;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7).
RC   TISSUE=Blood, Brain, Hepatoma, Tongue, and Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT VAL-314.
RC   TISSUE=Brain, and Endothelial cell;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1-505 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE
RP   MRNA] OF 24-564 (ISOFORM 1), AND VARIANT VAL-314.
RC   TISSUE=Chondrosarcoma, Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 160-564 (ISOFORMS 1/2/3/4/5/6).
RC   TISSUE=Brain;
RX   PubMed=9096115; DOI=10.1007/s003359900414;
RA   Becker K.G., Canning R.D., Nagle J.W., Dehejia A.M., Polymeropoulos M.H.,
RA   Lee I.J., Gado A.M., Biddison W.E., Drew P.D.;
RT   "Molecular cloning and mapping of a novel developmentally regulated human
RT   C2H2-type zinc finger.";
RL   Mamm. Genome 8:287-289(1997).
RN   [6]
RP   PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=7633419; DOI=10.1093/hmg/4.4.685;
RA   Becker K.G., Nagle J.W., Canning R.D., Biddison W.E., Ozato K., Drew P.D.;
RT   "Rapid isolation and characterization of 118 novel C2H2-type zinc finger
RT   cDNAs expressed in human brain.";
RL   Hum. Mol. Genet. 4:685-691(1995).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=8;
CC       Name=1;
CC         IsoId=Q13398-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q13398-2; Sequence=VSP_035702;
CC       Name=3;
CC         IsoId=Q13398-3; Sequence=VSP_035704;
CC       Name=4;
CC         IsoId=Q13398-4; Sequence=VSP_035705;
CC       Name=5;
CC         IsoId=Q13398-5; Sequence=VSP_035703;
CC       Name=6;
CC         IsoId=Q13398-6; Sequence=VSP_035706;
CC       Name=7;
CC         IsoId=Q13398-7; Sequence=VSP_045643;
CC       Name=8;
CC         IsoId=Q13398-8; Sequence=VSP_045643, VSP_046769;
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA93261.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH34351.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC       Sequence=BAD93084.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK026941; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK294869; BAG57971.1; -; mRNA.
DR   EMBL; AK296942; BAG59491.1; -; mRNA.
DR   EMBL; AK297047; BAG59573.1; -; mRNA.
DR   EMBL; AK304666; BAG65441.1; -; mRNA.
DR   EMBL; AB209273; BAD92510.1; -; mRNA.
DR   EMBL; AB209847; BAD93084.1; ALT_INIT; mRNA.
DR   EMBL; AC003682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC034351; AAH34351.1; ALT_SEQ; mRNA.
DR   EMBL; BC089440; AAH89440.1; -; mRNA.
DR   EMBL; BC110856; AAI10857.1; -; mRNA.
DR   EMBL; U38904; AAA93261.1; ALT_INIT; mRNA.
DR   CCDS; CCDS12956.1; -. [Q13398-7]
DR   CCDS; CCDS12957.1; -. [Q13398-1]
DR   CCDS; CCDS58686.1; -. [Q13398-8]
DR   CCDS; CCDS58687.1; -. [Q13398-2]
DR   CCDS; CCDS58688.1; -. [Q13398-5]
DR   RefSeq; NP_001252526.1; NM_001265597.2. [Q13398-8]
DR   RefSeq; NP_001252527.1; NM_001265598.2.
DR   RefSeq; NP_001252528.1; NM_001265599.2. [Q13398-2]
DR   RefSeq; NP_001252529.1; NM_001265600.2. [Q13398-5]
DR   RefSeq; NP_006376.2; NM_006385.4. [Q13398-7]
DR   RefSeq; NP_942152.1; NM_198855.3. [Q13398-1]
DR   AlphaFoldDB; Q13398; -.
DR   SMR; Q13398; -.
DR   BioGRID; 115775; 20.
DR   IntAct; Q13398; 16.
DR   iPTMnet; Q13398; -.
DR   PhosphoSitePlus; Q13398; -.
DR   BioMuta; ZNF211; -.
DR   DMDM; 215273921; -.
DR   jPOST; Q13398; -.
DR   MassIVE; Q13398; -.
DR   MaxQB; Q13398; -.
DR   PaxDb; Q13398; -.
DR   PeptideAtlas; Q13398; -.
DR   PRIDE; Q13398; -.
DR   ProteomicsDB; 31623; -.
DR   ProteomicsDB; 59366; -. [Q13398-1]
DR   ProteomicsDB; 59367; -. [Q13398-2]
DR   ProteomicsDB; 59368; -. [Q13398-3]
DR   ProteomicsDB; 59369; -. [Q13398-4]
DR   ProteomicsDB; 59370; -. [Q13398-5]
DR   ProteomicsDB; 59371; -. [Q13398-6]
DR   ProteomicsDB; 7564; -.
DR   Antibodypedia; 52687; 87 antibodies from 17 providers.
DR   DNASU; 10520; -.
DR   Ensembl; ENST00000240731.5; ENSP00000240731.4; ENSG00000121417.14. [Q13398-7]
DR   Ensembl; ENST00000254182.11; ENSP00000254182.7; ENSG00000121417.14. [Q13398-2]
DR   Ensembl; ENST00000299871.9; ENSP00000299871.5; ENSG00000121417.14. [Q13398-8]
DR   Ensembl; ENST00000347302.7; ENSP00000339562.3; ENSG00000121417.14. [Q13398-1]
DR   Ensembl; ENST00000391703.3; ENSP00000375584.3; ENSG00000121417.14. [Q13398-5]
DR   GeneID; 10520; -.
DR   KEGG; hsa:10520; -.
DR   MANE-Select; ENST00000240731.5; ENSP00000240731.4; NM_006385.5; NP_006376.2. [Q13398-7]
DR   UCSC; uc002qpp.3; human. [Q13398-1]
DR   CTD; 10520; -.
DR   DisGeNET; 10520; -.
DR   GeneCards; ZNF211; -.
DR   HGNC; HGNC:13003; ZNF211.
DR   HPA; ENSG00000121417; Low tissue specificity.
DR   MIM; 601856; gene.
DR   neXtProt; NX_Q13398; -.
DR   OpenTargets; ENSG00000121417; -.
DR   PharmGKB; PA37582; -.
DR   VEuPathDB; HostDB:ENSG00000121417; -.
DR   GeneTree; ENSGT00940000165092; -.
DR   HOGENOM; CLU_002678_0_2_1; -.
DR   InParanoid; Q13398; -.
DR   OMA; PNNSNEC; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q13398; -.
DR   TreeFam; TF339848; -.
DR   PathwayCommons; Q13398; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q13398; -.
DR   BioGRID-ORCS; 10520; 13 hits in 1100 CRISPR screens.
DR   ChiTaRS; ZNF211; human.
DR   GenomeRNAi; 10520; -.
DR   Pharos; Q13398; Tdark.
DR   PRO; PR:Q13398; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q13398; protein.
DR   Bgee; ENSG00000121417; Expressed in secondary oocyte and 151 other tissues.
DR   ExpressionAtlas; Q13398; baseline and differential.
DR   Genevisible; Q13398; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..564
FT                   /note="Zinc finger protein 211"
FT                   /id="PRO_0000047455"
FT   DOMAIN          33..106
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         131..157
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         257..279
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..335
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         341..363
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         425..447
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         453..475
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         481..503
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         509..531
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         537..559
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          85..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..72
FT                   /note="MLGFPPGRPQLPVQLRPQTRMATALRDPASGSVTFEDVAVYFSWEEWDLLDE
FT                   AQKHLYFDVMLENFALTSSL -> MLENFALTSSLGLISSWSHVVAQLGLGEVPSVLHR
FT                   MFMTPASARWDQRGPGLHEWHLGKGMSS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_035702"
FT   VAR_SEQ         1..61
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_035703"
FT   VAR_SEQ         1..30
FT                   /note="MLGFPPGRPQLPVQLRPQTRMATALRDPAS -> MRTLRQREVEYFSKATQL
FT                   VRGSTKDRGAQVPIATEVLFKLTQ (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035704"
FT   VAR_SEQ         1..30
FT                   /note="MLGFPPGRPQLPVQLRPQTRMATALRDPAS -> MISAYCNLHLLGSSDSPA
FT                   SASQVAGTTGMRHHAQ (in isoform 4)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_035705"
FT   VAR_SEQ         1..20
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_035706"
FT   VAR_SEQ         30
FT                   /note="S -> SVPIATEVLFKLTQ (in isoform 7 and isoform 8)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_045643"
FT   VAR_SEQ         73
FT                   /note="G -> GLISSWSHVVAQLGLGEVPSVLHRMFMTPASARWDQRGPGLHEWHLG
FT                   KGMSSG (in isoform 8)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_046769"
FT   VARIANT         110
FT                   /note="D -> N (in dbSNP:rs34897843)"
FT                   /id="VAR_047278"
FT   VARIANT         314
FT                   /note="A -> V (in dbSNP:rs11879465)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_057402"
FT   CONFLICT        178
FT                   /note="V -> A (in Ref. 1; AK026941)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276
FT                   /note="Q -> L (in Ref. 1; BAG59491)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   564 AA;  64535 MW;  9506968ED6E36EE7 CRC64;
     MLGFPPGRPQ LPVQLRPQTR MATALRDPAS GSVTFEDVAV YFSWEEWDLL DEAQKHLYFD
     VMLENFALTS SLGCWCGVEH EETPSEQRIS GERVPQFRTS KEGSSSQNAD SCEICCLVLR
     DILHLAEHQG TNCGQKLHTC GKQFYISANL QQHQRQHITE APFRSYVDTA SFTQSCIVHV
     SEKPFTCREI RKDFLANMRF LHQDATQTGE KPNNSNKCAV AFYSGKSHHN WGKCSKAFSH
     IDTLVQDQRI LTREGLFECS KCGKACTRRC NLIQHQKVHS EERPYECNEC GKFFTYYSSF
     IIHQRVHTGE RPYACPECGK SFSQIYSLNS HRKVHTGERP YECGECGKSF SQRSNLMQHR
     RVHTGERPYE CSECGKSFSQ NFSLIYHQRV HTGERPHECN ECGKSFSRSS SLIHHRRLHT
     GERPYECSKC GKSFKQSSSF SSHRKVHTGE RPYVCGECGK SFSHSSNLKN HQRVHTGERP
     VECSECSKSF SCKSNLIKHL RVHTGERPYE CSECGKSFSQ SSSLIQHRRV HTGKRPYQCS
     QCGKSFGCKS VLIQHQRVHI GEKP
 
 
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