ZN211_HUMAN
ID ZN211_HUMAN Reviewed; 564 AA.
AC Q13398; B4DH10; B4DLC9; B4E3C9; B9ZVS7; B9ZVW1; F8WDV2; Q05BQ7; Q2TAL7;
AC Q59EG4; Q59G36; Q5EBL6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 211;
DE AltName: Full=Zinc finger protein C2H2-25;
GN Name=ZNF211;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 5; 6 AND 7).
RC TISSUE=Blood, Brain, Hepatoma, Tongue, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT VAL-314.
RC TISSUE=Brain, and Endothelial cell;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-505 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE
RP MRNA] OF 24-564 (ISOFORM 1), AND VARIANT VAL-314.
RC TISSUE=Chondrosarcoma, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 160-564 (ISOFORMS 1/2/3/4/5/6).
RC TISSUE=Brain;
RX PubMed=9096115; DOI=10.1007/s003359900414;
RA Becker K.G., Canning R.D., Nagle J.W., Dehejia A.M., Polymeropoulos M.H.,
RA Lee I.J., Gado A.M., Biddison W.E., Drew P.D.;
RT "Molecular cloning and mapping of a novel developmentally regulated human
RT C2H2-type zinc finger.";
RL Mamm. Genome 8:287-289(1997).
RN [6]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RX PubMed=7633419; DOI=10.1093/hmg/4.4.685;
RA Becker K.G., Nagle J.W., Canning R.D., Biddison W.E., Ozato K., Drew P.D.;
RT "Rapid isolation and characterization of 118 novel C2H2-type zinc finger
RT cDNAs expressed in human brain.";
RL Hum. Mol. Genet. 4:685-691(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=1;
CC IsoId=Q13398-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13398-2; Sequence=VSP_035702;
CC Name=3;
CC IsoId=Q13398-3; Sequence=VSP_035704;
CC Name=4;
CC IsoId=Q13398-4; Sequence=VSP_035705;
CC Name=5;
CC IsoId=Q13398-5; Sequence=VSP_035703;
CC Name=6;
CC IsoId=Q13398-6; Sequence=VSP_035706;
CC Name=7;
CC IsoId=Q13398-7; Sequence=VSP_045643;
CC Name=8;
CC IsoId=Q13398-8; Sequence=VSP_045643, VSP_046769;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA93261.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH34351.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAD93084.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK026941; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK294869; BAG57971.1; -; mRNA.
DR EMBL; AK296942; BAG59491.1; -; mRNA.
DR EMBL; AK297047; BAG59573.1; -; mRNA.
DR EMBL; AK304666; BAG65441.1; -; mRNA.
DR EMBL; AB209273; BAD92510.1; -; mRNA.
DR EMBL; AB209847; BAD93084.1; ALT_INIT; mRNA.
DR EMBL; AC003682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034351; AAH34351.1; ALT_SEQ; mRNA.
DR EMBL; BC089440; AAH89440.1; -; mRNA.
DR EMBL; BC110856; AAI10857.1; -; mRNA.
DR EMBL; U38904; AAA93261.1; ALT_INIT; mRNA.
DR CCDS; CCDS12956.1; -. [Q13398-7]
DR CCDS; CCDS12957.1; -. [Q13398-1]
DR CCDS; CCDS58686.1; -. [Q13398-8]
DR CCDS; CCDS58687.1; -. [Q13398-2]
DR CCDS; CCDS58688.1; -. [Q13398-5]
DR RefSeq; NP_001252526.1; NM_001265597.2. [Q13398-8]
DR RefSeq; NP_001252527.1; NM_001265598.2.
DR RefSeq; NP_001252528.1; NM_001265599.2. [Q13398-2]
DR RefSeq; NP_001252529.1; NM_001265600.2. [Q13398-5]
DR RefSeq; NP_006376.2; NM_006385.4. [Q13398-7]
DR RefSeq; NP_942152.1; NM_198855.3. [Q13398-1]
DR AlphaFoldDB; Q13398; -.
DR SMR; Q13398; -.
DR BioGRID; 115775; 20.
DR IntAct; Q13398; 16.
DR iPTMnet; Q13398; -.
DR PhosphoSitePlus; Q13398; -.
DR BioMuta; ZNF211; -.
DR DMDM; 215273921; -.
DR jPOST; Q13398; -.
DR MassIVE; Q13398; -.
DR MaxQB; Q13398; -.
DR PaxDb; Q13398; -.
DR PeptideAtlas; Q13398; -.
DR PRIDE; Q13398; -.
DR ProteomicsDB; 31623; -.
DR ProteomicsDB; 59366; -. [Q13398-1]
DR ProteomicsDB; 59367; -. [Q13398-2]
DR ProteomicsDB; 59368; -. [Q13398-3]
DR ProteomicsDB; 59369; -. [Q13398-4]
DR ProteomicsDB; 59370; -. [Q13398-5]
DR ProteomicsDB; 59371; -. [Q13398-6]
DR ProteomicsDB; 7564; -.
DR Antibodypedia; 52687; 87 antibodies from 17 providers.
DR DNASU; 10520; -.
DR Ensembl; ENST00000240731.5; ENSP00000240731.4; ENSG00000121417.14. [Q13398-7]
DR Ensembl; ENST00000254182.11; ENSP00000254182.7; ENSG00000121417.14. [Q13398-2]
DR Ensembl; ENST00000299871.9; ENSP00000299871.5; ENSG00000121417.14. [Q13398-8]
DR Ensembl; ENST00000347302.7; ENSP00000339562.3; ENSG00000121417.14. [Q13398-1]
DR Ensembl; ENST00000391703.3; ENSP00000375584.3; ENSG00000121417.14. [Q13398-5]
DR GeneID; 10520; -.
DR KEGG; hsa:10520; -.
DR MANE-Select; ENST00000240731.5; ENSP00000240731.4; NM_006385.5; NP_006376.2. [Q13398-7]
DR UCSC; uc002qpp.3; human. [Q13398-1]
DR CTD; 10520; -.
DR DisGeNET; 10520; -.
DR GeneCards; ZNF211; -.
DR HGNC; HGNC:13003; ZNF211.
DR HPA; ENSG00000121417; Low tissue specificity.
DR MIM; 601856; gene.
DR neXtProt; NX_Q13398; -.
DR OpenTargets; ENSG00000121417; -.
DR PharmGKB; PA37582; -.
DR VEuPathDB; HostDB:ENSG00000121417; -.
DR GeneTree; ENSGT00940000165092; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q13398; -.
DR OMA; PNNSNEC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q13398; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q13398; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q13398; -.
DR BioGRID-ORCS; 10520; 13 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF211; human.
DR GenomeRNAi; 10520; -.
DR Pharos; Q13398; Tdark.
DR PRO; PR:Q13398; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q13398; protein.
DR Bgee; ENSG00000121417; Expressed in secondary oocyte and 151 other tissues.
DR ExpressionAtlas; Q13398; baseline and differential.
DR Genevisible; Q13398; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..564
FT /note="Zinc finger protein 211"
FT /id="PRO_0000047455"
FT DOMAIN 33..106
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 131..157
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 85..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..72
FT /note="MLGFPPGRPQLPVQLRPQTRMATALRDPASGSVTFEDVAVYFSWEEWDLLDE
FT AQKHLYFDVMLENFALTSSL -> MLENFALTSSLGLISSWSHVVAQLGLGEVPSVLHR
FT MFMTPASARWDQRGPGLHEWHLGKGMSS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035702"
FT VAR_SEQ 1..61
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035703"
FT VAR_SEQ 1..30
FT /note="MLGFPPGRPQLPVQLRPQTRMATALRDPAS -> MRTLRQREVEYFSKATQL
FT VRGSTKDRGAQVPIATEVLFKLTQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035704"
FT VAR_SEQ 1..30
FT /note="MLGFPPGRPQLPVQLRPQTRMATALRDPAS -> MISAYCNLHLLGSSDSPA
FT SASQVAGTTGMRHHAQ (in isoform 4)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_035705"
FT VAR_SEQ 1..20
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_035706"
FT VAR_SEQ 30
FT /note="S -> SVPIATEVLFKLTQ (in isoform 7 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045643"
FT VAR_SEQ 73
FT /note="G -> GLISSWSHVVAQLGLGEVPSVLHRMFMTPASARWDQRGPGLHEWHLG
FT KGMSSG (in isoform 8)"
FT /evidence="ECO:0000305"
FT /id="VSP_046769"
FT VARIANT 110
FT /note="D -> N (in dbSNP:rs34897843)"
FT /id="VAR_047278"
FT VARIANT 314
FT /note="A -> V (in dbSNP:rs11879465)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_057402"
FT CONFLICT 178
FT /note="V -> A (in Ref. 1; AK026941)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="Q -> L (in Ref. 1; BAG59491)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 564 AA; 64535 MW; 9506968ED6E36EE7 CRC64;
MLGFPPGRPQ LPVQLRPQTR MATALRDPAS GSVTFEDVAV YFSWEEWDLL DEAQKHLYFD
VMLENFALTS SLGCWCGVEH EETPSEQRIS GERVPQFRTS KEGSSSQNAD SCEICCLVLR
DILHLAEHQG TNCGQKLHTC GKQFYISANL QQHQRQHITE APFRSYVDTA SFTQSCIVHV
SEKPFTCREI RKDFLANMRF LHQDATQTGE KPNNSNKCAV AFYSGKSHHN WGKCSKAFSH
IDTLVQDQRI LTREGLFECS KCGKACTRRC NLIQHQKVHS EERPYECNEC GKFFTYYSSF
IIHQRVHTGE RPYACPECGK SFSQIYSLNS HRKVHTGERP YECGECGKSF SQRSNLMQHR
RVHTGERPYE CSECGKSFSQ NFSLIYHQRV HTGERPHECN ECGKSFSRSS SLIHHRRLHT
GERPYECSKC GKSFKQSSSF SSHRKVHTGE RPYVCGECGK SFSHSSNLKN HQRVHTGERP
VECSECSKSF SCKSNLIKHL RVHTGERPYE CSECGKSFSQ SSSLIQHRRV HTGKRPYQCS
QCGKSFGCKS VLIQHQRVHI GEKP