ZN213_HUMAN
ID ZN213_HUMAN Reviewed; 459 AA.
AC O14771; A8K1B9; B4DMG6; Q96IS1;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 30-APR-2003, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Zinc finger protein 213;
DE AltName: Full=Putative transcription factor CR53;
DE AltName: Full=Zinc finger protein with KRAB and SCAN domains 21;
GN Name=ZNF213; Synonyms=ZKSCAN21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Peripheral blood leukocyte;
RX PubMed=10023065; DOI=10.1016/s0167-4781(98)00273-5;
RA Chen X., Hamon M., Deng Z., Centola M., Sood R., Taylor K., Kastner D.L.,
RA Fischel-Ghodsian N.;
RT "Identification and characterization of a zinc finger gene (ZNF213) from
RT 16p13.3.";
RL Biochim. Biophys. Acta 1444:218-230(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC O14771; Q96G04: EEF2KMT; NbExp=3; IntAct=EBI-12838388, EBI-747840;
CC O14771; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-12838388, EBI-2510157;
CC O14771; P61968: LMO4; NbExp=3; IntAct=EBI-12838388, EBI-2798728;
CC O14771; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-12838388, EBI-739832;
CC O14771; O60437: PPL; NbExp=3; IntAct=EBI-12838388, EBI-368321;
CC O14771; P57086: SCAND1; NbExp=3; IntAct=EBI-12838388, EBI-745846;
CC O14771; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-12838388, EBI-10281938;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O14771-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O14771-2; Sequence=VSP_055942, VSP_055943;
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in testis.
CC {ECO:0000269|PubMed:10023065}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB70531.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF017433; AAB70531.1; ALT_FRAME; mRNA.
DR EMBL; AK289834; BAF82523.1; -; mRNA.
DR EMBL; AK291789; BAF84478.1; -; mRNA.
DR EMBL; AK297454; BAG59878.1; -; mRNA.
DR EMBL; AC108134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85394.1; -; Genomic_DNA.
DR EMBL; BC007287; AAH07287.1; -; mRNA.
DR CCDS; CCDS10495.1; -. [O14771-1]
DR RefSeq; NP_001128127.1; NM_001134655.1. [O14771-1]
DR RefSeq; NP_004211.1; NM_004220.2. [O14771-1]
DR AlphaFoldDB; O14771; -.
DR SMR; O14771; -.
DR BioGRID; 113543; 34.
DR IntAct; O14771; 14.
DR STRING; 9606.ENSP00000380087; -.
DR iPTMnet; O14771; -.
DR PhosphoSitePlus; O14771; -.
DR BioMuta; ZNF213; -.
DR EPD; O14771; -.
DR MassIVE; O14771; -.
DR PaxDb; O14771; -.
DR PeptideAtlas; O14771; -.
DR PRIDE; O14771; -.
DR ProteomicsDB; 4608; -.
DR ProteomicsDB; 48222; -. [O14771-1]
DR ABCD; O14771; 7 sequenced antibodies.
DR Antibodypedia; 10749; 177 antibodies from 20 providers.
DR DNASU; 7760; -.
DR Ensembl; ENST00000396878.8; ENSP00000380087.3; ENSG00000085644.14. [O14771-1]
DR Ensembl; ENST00000416391.6; ENSP00000403892.3; ENSG00000085644.14. [O14771-1]
DR Ensembl; ENST00000574902.5; ENSP00000460157.1; ENSG00000085644.14. [O14771-1]
DR Ensembl; ENST00000576416.5; ENSP00000459177.1; ENSG00000085644.14. [O14771-1]
DR GeneID; 7760; -.
DR KEGG; hsa:7760; -.
DR MANE-Select; ENST00000396878.8; ENSP00000380087.3; NM_004220.3; NP_004211.1.
DR UCSC; uc010bth.4; human. [O14771-1]
DR CTD; 7760; -.
DR GeneCards; ZNF213; -.
DR HGNC; HGNC:13005; ZNF213.
DR HPA; ENSG00000085644; Low tissue specificity.
DR MIM; 608387; gene.
DR neXtProt; NX_O14771; -.
DR OpenTargets; ENSG00000085644; -.
DR PharmGKB; PA37584; -.
DR VEuPathDB; HostDB:ENSG00000085644; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156663; -.
DR HOGENOM; CLU_002678_49_3_1; -.
DR InParanoid; O14771; -.
DR OMA; VPWEQHS; -.
DR PhylomeDB; O14771; -.
DR TreeFam; TF350828; -.
DR PathwayCommons; O14771; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; O14771; -.
DR BioGRID-ORCS; 7760; 19 hits in 1102 CRISPR screens.
DR GenomeRNAi; 7760; -.
DR Pharos; O14771; Tbio.
DR PRO; PR:O14771; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; O14771; protein.
DR Bgee; ENSG00000085644; Expressed in sperm and 183 other tissues.
DR ExpressionAtlas; O14771; baseline and differential.
DR Genevisible; O14771; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..459
FT /note="Zinc finger protein 213"
FT /id="PRO_0000047457"
FT DOMAIN 45..126
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 202..292
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 317..339
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..367
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 373..395
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 128..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..41
FT /note="MAAPLEAQDQAPGEGEGLLIVKVEDSSWEQESAQHEDGRDS -> MCPRRRR
FT NPRLQAGDPRPRGLPRRWGHGGGRLFPRSSTAIA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055942"
FT VAR_SEQ 42..199
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055943"
FT CONFLICT 407
FT /note="G -> A (in Ref. 1; AAB70531)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 459 AA; 51263 MW; 062F64A205533541 CRC64;
MAAPLEAQDQ APGEGEGLLI VKVEDSSWEQ ESAQHEDGRD SEACRQRFRQ FCYGDVHGPH
EAFSQLWELC CRWLRPELRT KEQILELLVL EQFLTVLPGE IQGWVREQHP GSGEEAVALV
EDLQKQPVKA WRQDVPSEEA EPEAAGRGSQ ATGPPPTVGA RRRPSVPQEQ HSHSAQPPAL
LKEGRPGETT DTCFVSGVHG PVALGDIPFY FSREEWGTLD PAQRDLFWDI KRENSRNTTL
GFGLKGQSEK SLLQEMVPVV PGQTGSDVTV SWSPEEAEAW ESENRPRAAL GPVVGARRGR
PPTRRRQFRD LAAEKPHSCG QCGKRFRWGS DLARHQRTHT GEKPHKCPEC DKSFRSSSDL
VRHQGVHTGE KPFSCSECGK SFSRSAYLAD HQRIHTGEKP FGCSDCGKSF SLRSYLLDHR
RVHTGERPFG CGECDKSFKQ RAHLIAHQSL HAKMAQPVG
