ZN215_PONAB
ID ZN215_PONAB Reviewed; 517 AA.
AC Q5RE50;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Zinc finger protein 215;
GN Name=ZNF215;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; CR857687; CAH89957.1; -; mRNA.
DR RefSeq; NP_001124919.1; NM_001131447.1.
DR AlphaFoldDB; Q5RE50; -.
DR SMR; Q5RE50; -.
DR STRING; 9601.ENSPPYP00000004043; -.
DR GeneID; 100171789; -.
DR KEGG; pon:100171789; -.
DR CTD; 7762; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q5RE50; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..517
FT /note="Zinc finger protein 215"
FT /id="PRO_0000281866"
FT DOMAIN 48..126
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 164..237
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 379..401
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 407..429
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 462..484
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 490..512
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 517 AA; 59962 MW; 2AECEDC50C42A188 CRC64;
MQPLSKLMAI SKPQNLSLHE QREVLRADMC WQQETIPVME THDSEASRQK FRHFQYLKVS
GPHEALSQLR ELCLQWLRPE IHTKKQIIEQ LVLEQFLAIL PEEVRTWVHL QHPNNSEDMV
TLIEDVIEML EDEGMPCKDS APQMGSIKEK MKAGSPTGKP QEPVTFKDVV VEFSKEEWGQ
LDSAVKNLYR NVMLENFRNL NSLRKAHLLS KPFESLKLES RKKRWIMEKE IPRKTIFDMK
SISGEESSHG VIVTRLTESG HPSSDVWKGE NWLYRNQKKW DINLPQEAFI PETSYTDEED
FECSENKETF DINSVSSICA IQQGIPSRKG SPKCDKFKTQ FKFNLDSVGK QHSEYEYVND
LSLRTDIRHQ KSHTTMNSYE CYQCGKAFCR SSSLIRHQII HTGEKPYKCS ECGRFFNRRT
NLTKHQKLHA EVKACTSNKC GKAVSKSEDG NNPALHFGNN FYECVNCGKS FNRSSSLIRH
QMIHTGEKPF KCKECNKAFN RSSNLVKHQK LHTRDKS
