ID   CC44_CAEEL              Reviewed;         489 AA.
AC   Q09660;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2001, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Probable cytochrome P450 CYP44;
DE            EC=1.14.-.-;
GN   Name=cyp-44A1; Synonyms=ccp-44, cyp44; ORFNames=ZK177.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       They oxidize a variety of structurally unrelated compounds, including
CC       steroids, fatty acids, and xenobiotics.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; FO080583; CCD64858.1; -; Genomic_DNA.
DR   RefSeq; NP_495052.1; NM_062651.3.
DR   AlphaFoldDB; Q09660; -.
DR   SMR; Q09660; -.
DR   STRING; 6239.ZK177.5.2; -.
DR   EPD; Q09660; -.
DR   PaxDb; Q09660; -.
DR   PeptideAtlas; Q09660; -.
DR   EnsemblMetazoa; ZK177.5.1; ZK177.5.1; WBGene00000375.
DR   GeneID; 173936; -.
DR   KEGG; cel:CELE_ZK177.5; -.
DR   UCSC; ZK177.5.1; c. elegans.
DR   CTD; 173936; -.
DR   WormBase; ZK177.5; CE25682; WBGene00000375; cyp-44A1.
DR   eggNOG; KOG0159; Eukaryota.
DR   HOGENOM; CLU_001570_28_0_1; -.
DR   InParanoid; Q09660; -.
DR   OMA; FHVECEE; -.
DR   OrthoDB; 871849at2759; -.
DR   PhylomeDB; Q09660; -.
DR   PRO; PR:Q09660; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000375; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..489
FT                   /note="Probable cytochrome P450 CYP44"
FT                   /id="PRO_0000052271"
FT   REGION          12..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         438
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   489 AA;  56071 MW;  3018607A061BFE43 CRC64;
     MRRSIRNLAE NVEKCPYSPT SSPNTPPRTF SEIPGPREIP VIGNIGYFKY AVKSDAKTIE
     NYNQHLEEMY KKYGKIVKEN LGFGRKYVVH IFDPADVQTV LAADGKTPFI VPLQETTQKY
     REMKGMNPGL GNLNGPEWYR LRSSVQHAMM RPQSVQTYLP FSQIVSNDLV CHVADQQKRF
     GLVDMQKVAG RWSLESAGQI LFEKSLGSLG NRSEWADGLI ELNKKIFQLS AKMRLGLPIF
     RLFSTPSWRK MVDLEDQFYS EVDRLMDDAL DKLKVNDSDS KDMRFASYLI NRKELNRRDV
     KVILLSMFSD GLSTTAPMLI YNLYNLATHP EALKEIQKEI KEDPASSKLT FLRACIKETF
     RMFPIGTEVS RVTQKNLILS GYEVPAGTAV DINTNVLMRH EVLFSDSPRE FKPQRWLEKS
     KEVHPFAYLP FGFGPRMCAG RRFAEQDLLT SLAKLCGNYD IRHRGDPITQ IYETLLLPRG
     DCTFEFKKL