ZN222_HUMAN
ID ZN222_HUMAN Reviewed; 451 AA.
AC Q9UK12; G5E9B9; Q8N6G7; Q9P1U5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Zinc finger protein 222;
GN Name=ZNF222;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT PHE-58.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UK12-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UK12-2; Sequence=VSP_046951, VSP_046952;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30261.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF187988; AAF04104.1; -; mRNA.
DR EMBL; AC067968; AAF66075.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW57242.1; -; Genomic_DNA.
DR EMBL; BC030261; AAH30261.1; ALT_INIT; mRNA.
DR CCDS; CCDS33045.1; -. [Q9UK12-1]
DR CCDS; CCDS46098.1; -. [Q9UK12-2]
DR PIR; B42177; B42177.
DR RefSeq; NP_001123468.1; NM_001129996.1. [Q9UK12-2]
DR RefSeq; NP_037492.2; NM_013360.2. [Q9UK12-1]
DR AlphaFoldDB; Q9UK12; -.
DR SMR; Q9UK12; -.
DR iPTMnet; Q9UK12; -.
DR PhosphoSitePlus; Q9UK12; -.
DR BioMuta; ZNF222; -.
DR DMDM; 116242857; -.
DR jPOST; Q9UK12; -.
DR MassIVE; Q9UK12; -.
DR PeptideAtlas; Q9UK12; -.
DR PRIDE; Q9UK12; -.
DR ProteomicsDB; 33894; -.
DR ProteomicsDB; 72176; -.
DR ProteomicsDB; 84703; -. [Q9UK12-1]
DR Antibodypedia; 843; 62 antibodies from 14 providers.
DR DNASU; 7673; -.
DR Ensembl; ENST00000187879.12; ENSP00000187879.6; ENSG00000159885.14. [Q9UK12-1]
DR Ensembl; ENST00000391960.4; ENSP00000375822.2; ENSG00000159885.14. [Q9UK12-2]
DR GeneID; 7673; -.
DR KEGG; hsa:7673; -.
DR MANE-Select; ENST00000391960.4; ENSP00000375822.2; NM_001129996.2; NP_001123468.1. [Q9UK12-2]
DR UCSC; uc002oyc.4; human. [Q9UK12-1]
DR CTD; 7673; -.
DR GeneCards; ZNF222; -.
DR HGNC; HGNC:13015; ZNF222.
DR HPA; ENSG00000159885; Low tissue specificity.
DR MIM; 617357; gene.
DR neXtProt; NX_Q9UK12; -.
DR OpenTargets; ENSG00000159885; -.
DR PharmGKB; PA37594; -.
DR VEuPathDB; HostDB:ENSG00000159885; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164111; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q9UK12; -.
DR OMA; QGEKCKQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UK12; -.
DR TreeFam; TF341885; -.
DR PathwayCommons; Q9UK12; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 7673; 14 hits in 1088 CRISPR screens.
DR ChiTaRS; ZNF222; human.
DR GenomeRNAi; 7673; -.
DR Pharos; Q9UK12; Tdark.
DR PRO; PR:Q9UK12; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UK12; protein.
DR Bgee; ENSG00000159885; Expressed in secondary oocyte and 119 other tissues.
DR ExpressionAtlas; Q9UK12; baseline and differential.
DR Genevisible; Q9UK12; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..451
FT /note="Zinc finger protein 222"
FT /id="PRO_0000047463"
FT DOMAIN 8..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..5
FT /note="MAKLY -> MIDSGEKKPGRRAE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046951"
FT VAR_SEQ 47
FT /note="V -> VGHQPFHGDTFHFLREEKFWVMGTTSQREGNL (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046952"
FT VARIANT 50
FT /note="K -> E (in dbSNP:rs11880330)"
FT /id="VAR_052796"
FT VARIANT 58
FT /note="V -> F (in dbSNP:rs7258517)"
FT /evidence="ECO:0000269|PubMed:12743021"
FT /id="VAR_052797"
FT VARIANT 82
FT /note="R -> G (in dbSNP:rs59926292)"
FT /id="VAR_061940"
FT VARIANT 263
FT /note="G -> D (in dbSNP:rs8112679)"
FT /id="VAR_052798"
SQ SEQUENCE 451 AA; 52484 MW; A54C0DC566138098 CRC64;
MAKLYEAVTF KDVAVIFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGGK IQTEMETVPE
AGTHEEFSCK QIWEQIASDL TRSQDTTISN SQLFEQDDNP SQIKARLSTV HTREKPFQGE
NCKQFFSDVS FFDLPQQLYS GEKSHTCDEC GKSFCYISAL HIHQRVHMGV KCYKCDVCGK
EFSQSSRLQT HQRVHTGEKP FKCEQCGKGF RCRSALKVHC KLHMREKPYN CEKCGKAFMH
NFQLQKHHRI HTGEKPFKCE ICGKSFCLRS SLNRHCMVHT AEKLYKSEKY GRGFIDRLDL
HKHQMIHMGQ KPYNCKECGK SFKWSSYLLV HQRVHTGEKP YKCEECGKGY ISKSGLDFHH
RTHTGERSYN CDNCGKSFRH ASSILNHKKL HCQRKPLKCE DCGKRLVCRS YCKDQQRDHS
GENPSKCEDC GKRYKRRLNL DIILSLFLND I
