ZN223_HUMAN
ID ZN223_HUMAN Reviewed; 482 AA.
AC Q9UK11; Q15736; Q8TBJ3; Q9HCA9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 223;
GN Name=ZNF223;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-138.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-138.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-138.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-78.
RX PubMed=8617494; DOI=10.1006/geno.1996.0166;
RA Shannon M., Ashworth L.K., Mucenski M.L., Lamerdin J.E., Branscomb E.,
RA Stubbs L.;
RT "Comparative analysis of a conserved zinc finger gene cluster on human
RT chromosome 19q and mouse chromosome 7.";
RL Genomics 33:112-120(1996).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-482.
RA Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Severin J., Gordon L.,
RA Shannon M., Brower A., Olsen A.S., Smith L.M.;
RT "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene
RT cluster.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UK11; Q9NP86: CABP5; NbExp=3; IntAct=EBI-10322867, EBI-10311131;
CC Q9UK11; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-10322867, EBI-3866279;
CC Q9UK11; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10322867, EBI-748961;
CC Q9UK11; P60409: KRTAP10-7; NbExp=4; IntAct=EBI-10322867, EBI-10172290;
CC Q9UK11; Q99750: MDFI; NbExp=7; IntAct=EBI-10322867, EBI-724076;
CC Q9UK11; Q9NQZ6: ZC4H2; NbExp=4; IntAct=EBI-10322867, EBI-747993;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB03531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF187989; AAF04105.1; -; mRNA.
DR EMBL; AK292327; BAF85016.1; -; mRNA.
DR EMBL; AC092072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022466; AAH22466.1; -; mRNA.
DR EMBL; U46189; AAB03531.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC084219; AAG23844.1; -; Genomic_DNA.
DR CCDS; CCDS12635.1; -.
DR RefSeq; NP_037493.3; NM_013361.5.
DR RefSeq; XP_016882747.1; XM_017027258.1.
DR RefSeq; XP_016882748.1; XM_017027259.1.
DR AlphaFoldDB; Q9UK11; -.
DR SMR; Q9UK11; -.
DR BioGRID; 113549; 34.
DR IntAct; Q9UK11; 26.
DR STRING; 9606.ENSP00000401947; -.
DR iPTMnet; Q9UK11; -.
DR PhosphoSitePlus; Q9UK11; -.
DR BioMuta; ZNF223; -.
DR DMDM; 311033504; -.
DR EPD; Q9UK11; -.
DR jPOST; Q9UK11; -.
DR MassIVE; Q9UK11; -.
DR PaxDb; Q9UK11; -.
DR PeptideAtlas; Q9UK11; -.
DR PRIDE; Q9UK11; -.
DR ProteomicsDB; 84702; -.
DR Antibodypedia; 17687; 80 antibodies from 19 providers.
DR DNASU; 7766; -.
DR Ensembl; ENST00000434772.8; ENSP00000401947.1; ENSG00000178386.13.
DR GeneID; 7766; -.
DR KEGG; hsa:7766; -.
DR MANE-Select; ENST00000434772.8; ENSP00000401947.1; NM_013361.6; NP_037493.3.
DR UCSC; uc002oyf.2; human.
DR CTD; 7766; -.
DR DisGeNET; 7766; -.
DR GeneCards; ZNF223; -.
DR HGNC; HGNC:13016; ZNF223.
DR HPA; ENSG00000178386; Low tissue specificity.
DR neXtProt; NX_Q9UK11; -.
DR OpenTargets; ENSG00000178386; -.
DR PharmGKB; PA37595; -.
DR VEuPathDB; HostDB:ENSG00000178386; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164111; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q9UK11; -.
DR OMA; GEKHNCE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UK11; -.
DR TreeFam; TF341885; -.
DR PathwayCommons; Q9UK11; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9UK11; -.
DR BioGRID-ORCS; 7766; 13 hits in 1095 CRISPR screens.
DR ChiTaRS; ZNF223; human.
DR GenomeRNAi; 7766; -.
DR Pharos; Q9UK11; Tdark.
DR PRO; PR:Q9UK11; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UK11; protein.
DR Bgee; ENSG00000178386; Expressed in secondary oocyte and 110 other tissues.
DR ExpressionAtlas; Q9UK11; baseline and differential.
DR Genevisible; Q9UK11; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..482
FT /note="Zinc finger protein 223"
FT /id="PRO_0000047464"
FT DOMAIN 8..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 176..198
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..450
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 60
FT /note="L -> I (in dbSNP:rs4130101)"
FT /id="VAR_060424"
FT VARIANT 138
FT /note="L -> I (in dbSNP:rs6509138)"
FT /evidence="ECO:0000269|PubMed:12743021,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_060425"
FT CONFLICT 25
FT /note="L -> M (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="C -> S (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 294..295
FT /note="SV -> GK (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 298
FT /note="R -> C (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="V -> M (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 312..323
FT /note="GKKPNSTGEYGK -> AEKLYKSEKYGR (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 327
FT /note="R -> D (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="C -> H (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 336
FT /note="T -> M (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 339..341
FT /note="TGE -> MGQ (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 354..355
FT /note="RR -> KW (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 361
FT /note="I -> V (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 375..376
FT /note="DK -> EE (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 380
FT /note="S -> G (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
FT CONFLICT 383
FT /note="T -> S (in Ref. 1; AAF04105)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 482 AA; 55763 MW; 2543E98D86F55E51 CRC64;
MTMSKEAVTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ PFHRDTFHFL
REEKFWMMDI ATQREGNSGG KIQPEMKTFP EAGPHEGWSC QQIWEEIASD LTRPQDSTIK
SSQFFEQGDA HSQVEEGLSI MHTGQKPSNC GKCKQSFSDM SIFDLPQQIR SAEKSHSCDE
CGKSFCYISA LHIHQRVHLG EKLFKCDVCG KEFSQSLHLQ THQRVHTGEK PFKCEQCGRG
FRCRSALTVH CKLHMGEKHY NCEACGRAFI HDFQLQKHQR IHTGEKPFKC EICSVSFRLR
SSLNRHCVVH TGKKPNSTGE YGKGFIRRLD LCKHQTIHTG EKPYNCKECG KSFRRSSYLL
IHQRVHTGEK PYKCDKCGKS YITKSGLDLH HRAHTGERPY NCDDCGKSFR QASSILNHKR
LHCRKKPFKC EDCGKKLVYR SYRKDQQKNH SGENPSKCED CGKRYKRRLN LDIILSLFLN
DT
