ZN226_HUMAN
ID ZN226_HUMAN Reviewed; 803 AA.
AC Q9NYT6; Q8WWE6; Q96TE6; Q9NS44;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2002, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Zinc finger protein 226;
GN Name=ZNF226;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NYT6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NYT6-2; Sequence=VSP_046853, VSP_046854;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF228418; AAF34786.1; -; mRNA.
DR EMBL; AK023091; BAB14398.1; -; mRNA.
DR EMBL; AC074331; AAF88103.1; -; Genomic_DNA.
DR EMBL; AC138470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW57259.1; -; Genomic_DNA.
DR EMBL; BC017786; AAH17786.1; -; mRNA.
DR EMBL; BC024197; AAH24197.1; -; mRNA.
DR CCDS; CCDS46102.1; -. [Q9NYT6-1]
DR CCDS; CCDS46103.1; -. [Q9NYT6-2]
DR RefSeq; NP_001027544.1; NM_001032372.1. [Q9NYT6-1]
DR RefSeq; NP_001027545.1; NM_001032373.1. [Q9NYT6-1]
DR RefSeq; NP_001027546.1; NM_001032374.1. [Q9NYT6-2]
DR RefSeq; NP_001139692.1; NM_001146220.2. [Q9NYT6-2]
DR RefSeq; NP_001306017.1; NM_001319088.1. [Q9NYT6-1]
DR RefSeq; NP_001306018.1; NM_001319089.1. [Q9NYT6-1]
DR RefSeq; NP_001306019.1; NM_001319090.1. [Q9NYT6-1]
DR RefSeq; NP_057003.2; NM_015919.3. [Q9NYT6-2]
DR RefSeq; NP_057528.2; NM_016444.2. [Q9NYT6-1]
DR RefSeq; XP_005259284.1; XM_005259227.2. [Q9NYT6-1]
DR RefSeq; XP_006723430.1; XM_006723367.3. [Q9NYT6-1]
DR RefSeq; XP_006723431.1; XM_006723368.3. [Q9NYT6-1]
DR RefSeq; XP_006723432.1; XM_006723369.2. [Q9NYT6-1]
DR RefSeq; XP_016882751.1; XM_017027262.1. [Q9NYT6-1]
DR RefSeq; XP_016882754.1; XM_017027265.1. [Q9NYT6-2]
DR AlphaFoldDB; Q9NYT6; -.
DR SMR; Q9NYT6; -.
DR BioGRID; 113552; 8.
DR IntAct; Q9NYT6; 4.
DR MINT; Q9NYT6; -.
DR STRING; 9606.ENSP00000465121; -.
DR iPTMnet; Q9NYT6; -.
DR PhosphoSitePlus; Q9NYT6; -.
DR BioMuta; ZNF226; -.
DR DMDM; 20178347; -.
DR EPD; Q9NYT6; -.
DR jPOST; Q9NYT6; -.
DR MassIVE; Q9NYT6; -.
DR MaxQB; Q9NYT6; -.
DR PaxDb; Q9NYT6; -.
DR PeptideAtlas; Q9NYT6; -.
DR PRIDE; Q9NYT6; -.
DR ProteomicsDB; 74878; -.
DR ProteomicsDB; 83275; -. [Q9NYT6-1]
DR Antibodypedia; 31162; 129 antibodies from 19 providers.
DR DNASU; 7769; -.
DR Ensembl; ENST00000300823.10; ENSP00000300823.5; ENSG00000167380.17. [Q9NYT6-2]
DR Ensembl; ENST00000337433.10; ENSP00000336719.5; ENSG00000167380.17. [Q9NYT6-1]
DR Ensembl; ENST00000413984.6; ENSP00000407474.1; ENSG00000167380.17. [Q9NYT6-2]
DR Ensembl; ENST00000454662.6; ENSP00000393265.1; ENSG00000167380.17. [Q9NYT6-1]
DR Ensembl; ENST00000588742.5; ENSP00000467003.1; ENSG00000167380.17. [Q9NYT6-2]
DR Ensembl; ENST00000590089.5; ENSP00000465121.1; ENSG00000167380.17. [Q9NYT6-1]
DR GeneID; 7769; -.
DR KEGG; hsa:7769; -.
DR MANE-Select; ENST00000337433.10; ENSP00000336719.5; NM_001032373.2; NP_001027545.1.
DR UCSC; uc002oyn.4; human. [Q9NYT6-1]
DR CTD; 7769; -.
DR GeneCards; ZNF226; -.
DR HGNC; HGNC:13019; ZNF226.
DR HPA; ENSG00000167380; Low tissue specificity.
DR neXtProt; NX_Q9NYT6; -.
DR OpenTargets; ENSG00000167380; -.
DR PharmGKB; PA37598; -.
DR VEuPathDB; HostDB:ENSG00000167380; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162119; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q9NYT6; -.
DR OMA; WISHHLD; -.
DR PhylomeDB; Q9NYT6; -.
DR TreeFam; TF350845; -.
DR PathwayCommons; Q9NYT6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9NYT6; -.
DR BioGRID-ORCS; 7769; 13 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF226; human.
DR GenomeRNAi; 7769; -.
DR Pharos; Q9NYT6; Tdark.
DR PRO; PR:Q9NYT6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NYT6; protein.
DR Bgee; ENSG00000167380; Expressed in tendon of biceps brachii and 181 other tissues.
DR ExpressionAtlas; Q9NYT6; baseline and differential.
DR Genevisible; Q9NYT6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 16.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..803
FT /note="Zinc finger protein 226"
FT /id="PRO_0000047467"
FT DOMAIN 8..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 252..274
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 475..497
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 503..525
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 531..553
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 559..581
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 587..609
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 615..637
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 643..665
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 671..693
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 699..721
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 727..749
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 755..777
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 781..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 79..94
FT /note="GEKNQSKLITVQDRES -> DTLLVKALLLYDLAQT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046853"
FT VAR_SEQ 95..803
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046854"
FT CONFLICT 195
FT /note="K -> E (in Ref. 1; AAF34786)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 803 AA; 91921 MW; 256DE75551A932A8 CRC64;
MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP PFKQDVSPIE
RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC WQIWQQIAND LTRCQDSMIN
NSQCHKQGDF PYQVGTELSI QISEDENYIV NKADGPNNTG NPEFPILRTQ DSWRKTFLTE
SQRLNRDQQI SIKNKLCQCK KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD
HNSMIHTGQK SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK
VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL NVHCKVHTAE
KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF SRNSHLQSHQ RVHTGEKPYK
CEECGKGFIC SSNLYIHQRV HTGEKPYKCE ECGKGFSRPS SLQAHQGVHT GEKSYICTVC
GKGFTLSSNL QAHQRVHTGE KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF
SQSSYLQIHQ KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA
DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK SFGRSAHLQA
HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK CGECGKYFSQ ASSLQLHQSV
HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD
KSYKSNRGGK NIRESTQEKK SIK
