ZN227_BOVIN
ID ZN227_BOVIN Reviewed; 787 AA.
AC A0JNB1;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Zinc finger protein 227;
GN Name=ZNF227;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC126592; AAI26593.1; -; mRNA.
DR RefSeq; NP_001071428.1; NM_001077960.1.
DR AlphaFoldDB; A0JNB1; -.
DR SMR; A0JNB1; -.
DR PRIDE; A0JNB1; -.
DR Ensembl; ENSBTAT00000017798; ENSBTAP00000017798; ENSBTAG00000027431.
DR GeneID; 524111; -.
DR KEGG; bta:524111; -.
DR CTD; 7770; -.
DR VEuPathDB; HostDB:ENSBTAG00000027431; -.
DR VGNC; VGNC:58349; ZNF227.
DR GeneTree; ENSGT00940000162819; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; A0JNB1; -.
DR OMA; ICEDFMK; -.
DR OrthoDB; 1318335at2759; -.
DR Reactome; R-BTA-212436; Generic Transcription Pathway.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000027431; Expressed in mesenteric lymph node and 104 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..787
FT /note="Zinc finger protein 227"
FT /id="PRO_0000284139"
FT DOMAIN 23..94
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 243..275
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..530
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 592..614
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 620..642
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 648..670
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 676..698
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 704..726
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 732..754
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 760..782
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 787 AA; 89360 MW; 2CDAA23D2ADD56FC CRC64;
MPSQDSDFPQ KEHEKMTEFQ EAVTFKDVAV VFTEEELGLL DSAQRKLYQD VMVENFRNLV
SVGHVPFKAD MVSQLETEEK LWTMERETQR NGHSSEIHSA VTSGSKIPNE METLGKVMFK
YLSCEELSCW QIWKHTTNDL TLQRKSSWFL HGDSLQVSED ENHIMNHKGD HFGCLENQEF
LIPTAQASCG SRCLSESENP SRGKQMSVKN HLHVCEGFTK NSPLSDPGKT DAKQTPCKGE
RPHPCRVCGE GFSHGAVLPV HQVDPGEKCS HLQTHQRIHP GGTVNKCPKS GDGFHQNSFH
PHHSNPTGEK SYRCDSCGKA FGSSTGLIIH YRTHTGEKPY RCEACGKCFS QSSNFQCHQR
VHTEEKPYKC EECGKGFGWS VNLRVHQRVH RGEKPYKCEE CGKGFTQAAH YHIHQRVHTG
EKPYKCDVCG KGFSHNSPLI CHRRVHTGEK PYRCEACGKG FTRNTDLHIH FRVHTGEKPY
TCKECGKGFS QASNLQVHQN VHTGEKRFKC ETCGKGFSQS SKLQTHQRVH TGEKPYRCDV
CGKDFSYSSN LKLHQVIHTG EKPYTCEACG KGFSWRSNLH AHQRVHSGEK PYKCEACDKS
FSQAIDFRVH QRVHTGEKPY KCGVCGKGFS QSSGLQSHQR VHTGEKPYKC DVCGKGFRYS
SQFIYHQRGH TGEKPYKCEE CGKGFGRSLN LRHHQRVHTG EKPHKCEECG KAFSLPSNLR
VHLSVHTREK LFKCEDCGKG FSQSSRLQAH QRVHTGEKPY KCNICGKDFS HRSRLTYHQK
VHTGKNL
