ZN232_HUMAN
ID ZN232_HUMAN Reviewed; 417 AA.
AC Q9UNY5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Zinc finger protein 232;
DE AltName: Full=Zinc finger and SCAN domain-containing protein 11;
GN Name=ZNF232; Synonyms=ZSCAN11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT).
RC TISSUE=Erythroleukemia;
RX PubMed=11311944; DOI=10.1016/s0167-4781(01)00177-4;
RA Mavrogiannis L.A., Argyrokastritis A., Tzitzikas N., Dermitzakis E.,
RA Sarafidou T., Patsalis P.C., Moschonas N.K.;
RT "ZNF232: structure and expression analysis of a novel human C(2)H(2) zinc
RT finger gene, member of the SCAN/LeR domain subfamily.";
RL Biochim. Biophys. Acta 1518:300-305(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] VAL-123.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UNY5; Q9UBB4: ATXN10; NbExp=3; IntAct=EBI-749023, EBI-702390;
CC Q9UNY5; P26378-2: ELAVL4; NbExp=3; IntAct=EBI-749023, EBI-21603100;
CC Q9UNY5; P50402: EMD; NbExp=3; IntAct=EBI-749023, EBI-489887;
CC Q9UNY5; P01100: FOS; NbExp=3; IntAct=EBI-749023, EBI-852851;
CC Q9UNY5; P51116: FXR2; NbExp=3; IntAct=EBI-749023, EBI-740459;
CC Q9UNY5; P14136: GFAP; NbExp=3; IntAct=EBI-749023, EBI-744302;
CC Q9UNY5; P62993: GRB2; NbExp=3; IntAct=EBI-749023, EBI-401755;
CC Q9UNY5; P42261: GRIA1; NbExp=3; IntAct=EBI-749023, EBI-6980805;
CC Q9UNY5; Q00613: HSF1; NbExp=3; IntAct=EBI-749023, EBI-719620;
CC Q9UNY5; O43464: HTRA2; NbExp=3; IntAct=EBI-749023, EBI-517086;
CC Q9UNY5; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-749023, EBI-1055254;
CC Q9UNY5; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-749023, EBI-742948;
CC Q9UNY5; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-749023, EBI-11522433;
CC Q9UNY5; P19404: NDUFV2; NbExp=3; IntAct=EBI-749023, EBI-713665;
CC Q9UNY5; P29474: NOS3; NbExp=3; IntAct=EBI-749023, EBI-1391623;
CC Q9UNY5; Q16512: PKN1; NbExp=3; IntAct=EBI-749023, EBI-602382;
CC Q9UNY5; D3DTS7: PMP22; NbExp=3; IntAct=EBI-749023, EBI-25882629;
CC Q9UNY5; Q96CD2: PPCDC; NbExp=6; IntAct=EBI-749023, EBI-724333;
CC Q9UNY5; P41219: PRPH; NbExp=3; IntAct=EBI-749023, EBI-752074;
CC Q9UNY5; P62491: RAB11A; NbExp=3; IntAct=EBI-749023, EBI-745098;
CC Q9UNY5; P12931: SRC; NbExp=3; IntAct=EBI-749023, EBI-621482;
CC Q9UNY5; P31930: UQCRC1; NbExp=3; IntAct=EBI-749023, EBI-1052596;
CC Q9UNY5; P61758: VBP1; NbExp=3; IntAct=EBI-749023, EBI-357430;
CC Q9UNY5; P17028: ZNF24; NbExp=3; IntAct=EBI-749023, EBI-707773;
CC Q9UNY5; Q9NWS9-2: ZNF446; NbExp=7; IntAct=EBI-749023, EBI-740232;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q9UNY5-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q9UNY5-2; Sequence=VSP_006906;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Higher expression seen in the liver,
CC testis and ovary.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16039.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF080171; AAD46135.1; -; Genomic_DNA.
DR EMBL; AF080170; AAD46135.1; JOINED; Genomic_DNA.
DR EMBL; Y15067; CAB95963.1; -; mRNA.
DR EMBL; AC012146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC016039; AAH16039.2; ALT_INIT; mRNA.
DR RefSeq; NP_001307882.1; NM_001320953.1. [Q9UNY5-1]
DR RefSeq; NP_001307883.1; NM_001320954.1. [Q9UNY5-1]
DR RefSeq; NP_055334.2; NM_014519.3.
DR RefSeq; XP_016880510.1; XM_017025021.1.
DR AlphaFoldDB; Q9UNY5; -.
DR SMR; Q9UNY5; -.
DR BioGRID; 113557; 53.
DR IntAct; Q9UNY5; 67.
DR STRING; 9606.ENSP00000250076; -.
DR iPTMnet; Q9UNY5; -.
DR PhosphoSitePlus; Q9UNY5; -.
DR BioMuta; ZNF232; -.
DR DMDM; 11136137; -.
DR jPOST; Q9UNY5; -.
DR MassIVE; Q9UNY5; -.
DR MaxQB; Q9UNY5; -.
DR PaxDb; Q9UNY5; -.
DR PeptideAtlas; Q9UNY5; -.
DR PRIDE; Q9UNY5; -.
DR ProteomicsDB; 85344; -. [Q9UNY5-1]
DR ProteomicsDB; 85345; -. [Q9UNY5-2]
DR ABCD; Q9UNY5; 1 sequenced antibody.
DR Antibodypedia; 23598; 209 antibodies from 29 providers.
DR DNASU; 7775; -.
DR Ensembl; ENST00000250076.7; ENSP00000250076.3; ENSG00000167840.13.
DR GeneID; 7775; -.
DR KEGG; hsa:7775; -.
DR UCSC; uc002gat.4; human. [Q9UNY5-1]
DR CTD; 7775; -.
DR DisGeNET; 7775; -.
DR GeneCards; ZNF232; -.
DR HGNC; HGNC:13026; ZNF232.
DR HPA; ENSG00000167840; Low tissue specificity.
DR MIM; 616463; gene.
DR neXtProt; NX_Q9UNY5; -.
DR PharmGKB; PA37604; -.
DR VEuPathDB; HostDB:ENSG00000167840; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q9UNY5; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UNY5; -.
DR TreeFam; TF338304; -.
DR PathwayCommons; Q9UNY5; -.
DR SignaLink; Q9UNY5; -.
DR BioGRID-ORCS; 7775; 9 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF232; human.
DR GenomeRNAi; 7775; -.
DR Pharos; Q9UNY5; Tdark.
DR PRO; PR:Q9UNY5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9UNY5; protein.
DR Bgee; ENSG00000167840; Expressed in endothelial cell and 191 other tissues.
DR ExpressionAtlas; Q9UNY5; baseline and differential.
DR Genevisible; Q9UNY5; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..417
FT /note="Zinc finger protein 232"
FT /id="PRO_0000047472"
FT DOMAIN 52..134
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT ZN_FING 276..298
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..326
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 134..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 182..190
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:11311944"
FT /id="VSP_006906"
FT VARIANT 123
FT /note="A -> V (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035573"
SQ SEQUENCE 417 AA; 47688 MW; 6FF80EFAB3AF8AE9 CRC64;
MAVSLTAAET LALQGTQGQE KMMMMGPKEE EQSCEYETRL PGNHSTSQEI FRQRFRHLRY
QETPGPREAL SQLRVLCCEW LRPEKHTKEQ ILEFLVLEQF LTILPEELQS WVRGHHPKSG
EEAVTVLEDL EKGLEPEPQV PGPAHGPAQE EPWEKKESLG AAQEALSIQL QPKETQPFPK
SEQVYLHFLS VVTEDGPEPK DKGSLPQPPI TEVESQVFSE KLATDTSTFE ATSEGTLELQ
QRNPKAERLR WSPAQEESFR QMVVIHKEIP TGKKDHECSE CGKTFIYNSH LVVHQRVHSG
EKPYKCSDCG KTFKQSSNLG QHQRIHTGEK PFECNECGKA FRWGAHLVQH QRIHSGEKPY
ECNECGKAFS QSSYLSQHRR IHSGEKPFIC KECGKAYGWC SELIRHRRVH ARKEPSH
