ZN233_HUMAN
ID ZN233_HUMAN Reviewed; 670 AA.
AC A6NK53; B2RN78; B2RN79; Q86WL8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Zinc finger protein 233;
GN Name=ZNF233;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-531.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-531.
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-531.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 46-153.
RC TISSUE=Testis;
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK095351; BAG53032.1; -; mRNA.
DR EMBL; AC138470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136734; AAI36735.1; -; mRNA.
DR EMBL; BC136735; AAI36736.1; -; mRNA.
DR EMBL; AY166792; AAO45841.1; -; mRNA.
DR CCDS; CCDS33047.1; -.
DR RefSeq; NP_001193934.1; NM_001207005.1.
DR RefSeq; NP_861421.2; NM_181756.2.
DR AlphaFoldDB; A6NK53; -.
DR SMR; A6NK53; -.
DR BioGRID; 131691; 1.
DR IntAct; A6NK53; 4.
DR STRING; 9606.ENSP00000375820; -.
DR iPTMnet; A6NK53; -.
DR PhosphoSitePlus; A6NK53; -.
DR BioMuta; ZNF233; -.
DR jPOST; A6NK53; -.
DR MassIVE; A6NK53; -.
DR PaxDb; A6NK53; -.
DR PeptideAtlas; A6NK53; -.
DR PRIDE; A6NK53; -.
DR ProteomicsDB; 1377; -.
DR Antibodypedia; 17700; 26 antibodies from 13 providers.
DR DNASU; 353355; -.
DR Ensembl; ENST00000391958.6; ENSP00000375820.1; ENSG00000159915.13.
DR Ensembl; ENST00000683810.1; ENSP00000507588.1; ENSG00000159915.13.
DR GeneID; 353355; -.
DR KEGG; hsa:353355; -.
DR MANE-Select; ENST00000683810.1; ENSP00000507588.1; NM_001207005.2; NP_001193934.1.
DR UCSC; uc002oyz.3; human.
DR CTD; 353355; -.
DR DisGeNET; 353355; -.
DR GeneCards; ZNF233; -.
DR HGNC; HGNC:30946; ZNF233.
DR HPA; ENSG00000159915; Tissue enhanced (testis).
DR neXtProt; NX_A6NK53; -.
DR OpenTargets; ENSG00000159915; -.
DR PharmGKB; PA134917179; -.
DR VEuPathDB; HostDB:ENSG00000159915; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163265; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; A6NK53; -.
DR OMA; HCVRQRI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A6NK53; -.
DR TreeFam; TF350845; -.
DR PathwayCommons; A6NK53; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A6NK53; -.
DR BioGRID-ORCS; 353355; 7 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF233; human.
DR GenomeRNAi; 353355; -.
DR Pharos; A6NK53; Tdark.
DR PRO; PR:A6NK53; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A6NK53; protein.
DR Bgee; ENSG00000159915; Expressed in sperm and 115 other tissues.
DR ExpressionAtlas; A6NK53; baseline and differential.
DR Genevisible; A6NK53; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..670
FT /note="Zinc finger protein 233"
FT /id="PRO_0000304407"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 258..280
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..336
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..530
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 592..614
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 620..642
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 247
FT /note="S -> P (in dbSNP:rs16978899)"
FT /id="VAR_035022"
FT VARIANT 531
FT /note="K -> T (in dbSNP:rs1233428)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15057824, ECO:0000269|PubMed:15489334"
FT /id="VAR_035023"
FT CONFLICT 138
FT /note="D -> G (in Ref. 4; AAO45841)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 670 AA; 76861 MW; 531D751D1CE4BDA5 CRC64;
MTKFQEMVTF KDVAVVFTRE ELGLLDLAQR KLYQDVMLEN FRNLLSVGYQ PFKLDVILQL
GKEDKLRMME TEIQGDGCSG HKNQNEIDTL QEVRLRFLSY EDLICWQIWE QFTSKLTSNQ
DLIINLQGKR SKLLKQGDSP CQVWTGESSQ VSEDENYVIK LQGESSNSIK NQELPLRTTW
DFWRKMYLRE PQNYQSRCQQ IDVKNKLCKC DHCVRQRIAH QHDDHGVHKR EKAFSHNNCG
KDCVKESSQH SIIQSGEQTS DENGKGLSVG SNLELHQQLH LRDKPHVNVE YGKGIGYSSG
LPRHQCFHIG EKCYRNGDSG EGFSQGSHLQ PHQRVSTGEN LYRCQVYARS SNQNSCLPSH
ELTHPGEKLC TCGRCGKGFH HSLDFDIHCV DSAGERACKC DVYDKGFSQT SQLQAHQRGH
SRDKTYKWEV SDRIFNRNSG LHQRVHTGEK PYKCEVCDKG FSKASNLQAH QRIHTGEKPY
KCDVCDKNFS RNSHLQAHQR VHTGEKPYKC DTCGKDFSQI SHLQAHQRVH KGEKPYKCET
CGKGFSQSSH LQDHQQVHTG ENPYKCDVCG KGFSWSSHLQ AHQRVHTGEK PYKCEECRKG
FIWNSYLHVH QRIHTGEKPY KCGMCGKSFS QTSHLQAHQR VHTGEKPYKC FVCGKGFSKS
SLSSDSSESP
