ZN234_HUMAN
ID ZN234_HUMAN Reviewed; 700 AA.
AC Q14588; A8K1C8; Q96IR4; Q9NS45; Q9NYT7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 200.
DE RecName: Full=Zinc finger protein 234;
DE AltName: Full=Zinc finger protein 269;
DE AltName: Full=Zinc finger protein HZF4;
GN Name=ZNF234; Synonyms=ZNF269;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-698.
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-698.
RA Kodoyianni V., Ge Y., Severin J., Krummel G.K., Grable L., Kvikstad E.,
RA Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.;
RT "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene
RT cluster.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK289843; BAF82532.1; -; mRNA.
DR EMBL; CH471126; EAW57256.1; -; Genomic_DNA.
DR EMBL; BC007303; AAH07303.1; -; mRNA.
DR EMBL; AF228417; AAF34785.1; -; mRNA.
DR EMBL; X78927; CAA55527.1; -; mRNA.
DR EMBL; AC074331; AAF88104.1; -; Genomic_DNA.
DR CCDS; CCDS46101.1; -.
DR PIR; I37570; I37570.
DR RefSeq; NP_001138296.1; NM_001144824.1.
DR RefSeq; NP_006621.1; NM_006630.2.
DR RefSeq; XP_006723037.1; XM_006722974.3.
DR RefSeq; XP_016881638.1; XM_017026149.1.
DR AlphaFoldDB; Q14588; -.
DR SMR; Q14588; -.
DR BioGRID; 115997; 4.
DR IntAct; Q14588; 2.
DR STRING; 9606.ENSP00000400878; -.
DR iPTMnet; Q14588; -.
DR PhosphoSitePlus; Q14588; -.
DR BioMuta; ZNF234; -.
DR DMDM; 55977851; -.
DR jPOST; Q14588; -.
DR MassIVE; Q14588; -.
DR PaxDb; Q14588; -.
DR PeptideAtlas; Q14588; -.
DR PRIDE; Q14588; -.
DR ProteomicsDB; 60062; -.
DR Antibodypedia; 61741; 29 antibodies from 12 providers.
DR DNASU; 10780; -.
DR Ensembl; ENST00000426739.7; ENSP00000400878.1; ENSG00000263002.8.
DR Ensembl; ENST00000592437.5; ENSP00000465011.1; ENSG00000263002.8.
DR GeneID; 10780; -.
DR KEGG; hsa:10780; -.
DR MANE-Select; ENST00000426739.7; ENSP00000400878.1; NM_006630.3; NP_006621.1.
DR UCSC; uc002oyl.5; human.
DR CTD; 10780; -.
DR DisGeNET; 10780; -.
DR GeneCards; ZNF234; -.
DR HGNC; HGNC:13027; ZNF234.
DR HPA; ENSG00000263002; Low tissue specificity.
DR MIM; 604750; gene.
DR neXtProt; NX_Q14588; -.
DR OpenTargets; ENSG00000263002; -.
DR PharmGKB; PA37605; -.
DR VEuPathDB; HostDB:ENSG00000263002; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163462; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q14588; -.
DR OMA; LYQCDKY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14588; -.
DR PathwayCommons; Q14588; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q14588; -.
DR BioGRID-ORCS; 10780; 14 hits in 1088 CRISPR screens.
DR ChiTaRS; ZNF234; human.
DR GenomeRNAi; 10780; -.
DR Pharos; Q14588; Tdark.
DR PRO; PR:Q14588; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q14588; protein.
DR Bgee; ENSG00000263002; Expressed in adrenal tissue and 112 other tissues.
DR ExpressionAtlas; Q14588; baseline and differential.
DR Genevisible; Q14588; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 17.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..700
FT /note="Zinc finger protein 234"
FT /id="PRO_0000047473"
FT DOMAIN 8..90
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 148..170
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 176..198
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..450
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 456..478
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 484..506
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 512..534
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 540..562
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 568..590
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 596..618
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 624..646
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 652..674
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 91..147
FT /note="KRNB"
FT VARIANT 16
FT /note="V -> I (in dbSNP:rs2293587)"
FT /id="VAR_019977"
FT VARIANT 208
FT /note="V -> M (in dbSNP:rs11668974)"
FT /id="VAR_052799"
FT CONFLICT 494
FT /note="S -> N (in Ref. 5; CAA55527)"
FT /evidence="ECO:0000305"
FT CONFLICT 600
FT /note="E -> A (in Ref. 5; CAA55527)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 700 AA; 80560 MW; 79F266EA18821193 CRC64;
MTTFKEGLTF KDVAVVFTEE ELGLLDPVQR NLYQDVMLEN FRNLLSVGHH PFKHDVFLLE
KEKKLDIMKT ATQRKGKSAD KIQSEVETVP EAGRHEELYW GQIWKQIASD LIKYEDSMIS
ISRFPRQGDL SCQVRAGLYT THTGQKFYQC DEYKKSFTDV FNFDLHQQLH SGEKSHTCDE
CGKSFCYISA LHIHQRVHMG EKCYKCDVCG KEFSQSSHLQ THQRVHTVEK PFKCVECGKG
FSRRSTLTVH CKLHSGEKPY NCEECGRAFI HASHLQEHQR IHTGEKPFKC DTCGKNFRRR
SALNNHCMVH TGEKPYKCED CGKCFTCSSN LRIHQRVHTG EKPYKCEECG KCFIQPSQFQ
AHRRIHTGEK PYVCKVCGKG FIYSSSFQAH QGVHTGEKPY KCNECGKSFR MKIHYQVHLV
VHTGEKPYKC EVCGKAFRQS SYLKIHLKAH SVQKPFKCEE CGQGFNQSSR LQIHQLIHTG
EKPYKCEECG KGFSRRADLK IHCRIHTGEK PYNCEECGKV FSQASHLLTH QRVHSGEKPF
KCEECGKSFS RSAHLQAHQK VHTGEKPYKC GECGKGFKWS LNLDMHQRVH TGEKPYTCGE
CGKHFSQASS LQLHQSVHTG EKPYKCDVCG KVFSRSSQLQ YHRRVHTGEK PYKCEICGKR
FSWRSNLVSH HKIHAAGTFY ENDENSKNIR ELSEGGSSTR
