ZN235_HUMAN
ID ZN235_HUMAN Reviewed; 738 AA.
AC Q14590; B4DTQ7; O14898; O14899; Q17RR8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 194.
DE RecName: Full=Zinc finger protein 235;
DE AltName: Full=Zinc finger protein 270;
DE AltName: Full=Zinc finger protein 93 homolog;
DE Short=Zfp-93;
DE AltName: Full=Zinc finger protein HZF6;
GN Name=ZNF235; Synonyms=ZFP93, ZNF270;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT PRO-296.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-506 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [MRNA] OF 637-738 (ISOFORMS 1/2).
RX PubMed=9570955; DOI=10.1006/geno.1998.5230;
RA Shannon M., Stubbs L.;
RT "Analysis of homologous XRCC1-linked zinc-finger gene families in human and
RT mouse: evidence for orthologous genes.";
RL Genomics 49:112-121(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 456-664 (ISOFORMS 1/2).
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 637-738 (ISOFORMS 1/2).
RA Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Grable L., Severin J.,
RA Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.;
RT "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene
RT cluster.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14590-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14590-2; Sequence=VSP_022166;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK300317; BAG62069.1; -; mRNA.
DR EMBL; AC092477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC138473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117215; AAI17216.1; -; mRNA.
DR EMBL; AF027513; AAD12728.1; -; mRNA.
DR EMBL; AF027514; AAD12729.1; -; mRNA.
DR EMBL; X78929; CAA55529.1; -; mRNA.
DR EMBL; AC084239; AAG23969.1; -; Genomic_DNA.
DR CCDS; CCDS33048.1; -. [Q14590-1]
DR PIR; S47068; S47068.
DR RefSeq; NP_004225.3; NM_004234.4. [Q14590-1]
DR RefSeq; XP_005259469.1; XM_005259412.4. [Q14590-2]
DR AlphaFoldDB; Q14590; -.
DR SMR; Q14590; -.
DR BioGRID; 114722; 12.
DR IntAct; Q14590; 6.
DR MINT; Q14590; -.
DR STRING; 9606.ENSP00000291182; -.
DR iPTMnet; Q14590; -.
DR PhosphoSitePlus; Q14590; -.
DR BioMuta; ZNF235; -.
DR DMDM; 215274192; -.
DR EPD; Q14590; -.
DR jPOST; Q14590; -.
DR MassIVE; Q14590; -.
DR PaxDb; Q14590; -.
DR PeptideAtlas; Q14590; -.
DR PRIDE; Q14590; -.
DR ProteomicsDB; 60063; -. [Q14590-1]
DR ProteomicsDB; 60064; -. [Q14590-2]
DR Antibodypedia; 49043; 25 antibodies from 12 providers.
DR DNASU; 9310; -.
DR Ensembl; ENST00000291182.9; ENSP00000291182.3; ENSG00000159917.17. [Q14590-1]
DR Ensembl; ENST00000650576.1; ENSP00000497018.1; ENSG00000159917.17. [Q14590-2]
DR GeneID; 9310; -.
DR KEGG; hsa:9310; -.
DR MANE-Select; ENST00000291182.9; ENSP00000291182.3; NM_004234.4; NP_004225.3.
DR UCSC; uc002oza.5; human. [Q14590-1]
DR CTD; 9310; -.
DR DisGeNET; 9310; -.
DR GeneCards; ZNF235; -.
DR HGNC; HGNC:12866; ZNF235.
DR HPA; ENSG00000159917; Low tissue specificity.
DR MIM; 604749; gene.
DR neXtProt; NX_Q14590; -.
DR OpenTargets; ENSG00000159917; -.
DR PharmGKB; PA37455; -.
DR VEuPathDB; HostDB:ENSG00000159917; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162402; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q14590; -.
DR OMA; QIKRHVV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14590; -.
DR TreeFam; TF350845; -.
DR PathwayCommons; Q14590; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q14590; -.
DR BioGRID-ORCS; 9310; 4 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF235; human.
DR GenomeRNAi; 9310; -.
DR Pharos; Q14590; Tdark.
DR PRO; PR:Q14590; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q14590; protein.
DR Bgee; ENSG00000159917; Expressed in secondary oocyte and 103 other tissues.
DR ExpressionAtlas; Q14590; baseline and differential.
DR Genevisible; Q14590; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 16.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..738
FT /note="Zinc finger protein 235"
FT /id="PRO_0000047474"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 263..285
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..425
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..453
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 459..481
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 487..509
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 515..537
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 543..565
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 571..593
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 599..621
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 627..649
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 655..677
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 683..705
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 711..733
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 77..80
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022166"
FT VARIANT 296
FT /note="H -> P (in dbSNP:rs2125579)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_029806"
FT CONFLICT 123
FT /note="M -> T (in Ref. 4; AAD12728)"
FT /evidence="ECO:0000305"
FT CONFLICT 635
FT /note="A -> P (in Ref. 5; CAA55529)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 738 AA; 83977 MW; 51B301BFF30EB194 CRC64;
MTKFQEAVTF KDVAVAFTEE ELGLLDSAQR KLYRDVMLEN FRNLVSVGHQ SFKPDMISQL
EREEKLWMKE LQTQRGKHSG DRNQNEMATL HKAGLRCFSL GELSCWQIKR HIASKLARSQ
DSMINIEGKS SQFPKHHDSP CQVGAGESIQ ASVDDNCLVN HIGDHSSIIE NQEFPTGKVP
NSWSKIYLNE TQNYQRSCKQ TQMKNKLCIF APYVDIFSCI SHHHDDNIVH KRDKVHSNSD
CGKDTLKVSP LTQRSIHTGQ KTYQGNECEE AFNDSSSLEL HKQVHLGKKS PACSTHEKDT
SYSSGIPVQQ SVRTGKKRYW CHECGKGFSQ SSNLQTHQRV HTGEKPYTCH ECGKSFNQSS
HLYAHLPIHT GEKPYRCDSC GKGFSRSTDL NIHCRVHTGE KPYKCEVCGK GFTQRSHLQA
HERIHTGEKP YKCGDCGKRF SCSSNLHTHQ RVHTEEKPYK CDECGKCFSL SFNLHSHQRV
HTGEKPYKCE ECGKGFSSAS SFQSHQRVHT GEKPFRCNVC GKGFSQSSYF QAHQRVHTGE
KPYKCEVCGK RFNWSLNLHN HQRVHTGEKP YKCEECGKGF SQASNLQAHQ SVHTGEKPFK
CDACQKRFSQ ASHLQAHQRV HTGEKPYKCD TCGKAFSQRS NLQVHQIIHT GEKPFKCEEC
GKEFSWSAGL SAHQRVHTGE KPYTCQQCGK GFSQASHFHT HQRVHTGERP YICDVCCKGF
SQRSHLIYHQ RVHTGGNL
