ZN235_MOUSE
ID ZN235_MOUSE Reviewed; 645 AA.
AC Q61116; Q3UKA3; Q8CE70;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Zinc finger protein 235;
DE AltName: Full=Zinc finger protein 93;
DE Short=Zfp-93;
GN Name=Znf235; Synonyms=Zfp93;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Testis;
RX PubMed=8617494; DOI=10.1006/geno.1996.0166;
RA Shannon M., Ashworth L.K., Mucenski M.L., Lamerdin J.E., Branscomb E.,
RA Stubbs L.;
RT "Comparative analysis of a conserved zinc finger gene cluster on human
RT chromosome 19q and mouse chromosome 7.";
RL Genomics 33:112-120(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Placenta, Skin, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U46186; AAB03529.1; -; mRNA.
DR EMBL; AK028905; BAC26187.1; -; mRNA.
DR EMBL; AK040325; BAC30565.1; -; mRNA.
DR EMBL; AK132229; BAE21045.1; -; mRNA.
DR EMBL; AK146095; BAE26898.1; -; mRNA.
DR EMBL; BC003776; AAH03776.1; -; mRNA.
DR CCDS; CCDS39828.1; -.
DR RefSeq; NP_033593.1; NM_009567.4.
DR RefSeq; XP_017177632.1; XM_017322143.1.
DR AlphaFoldDB; Q61116; -.
DR SMR; Q61116; -.
DR BioGRID; 204682; 28.
DR STRING; 10090.ENSMUSP00000032696; -.
DR iPTMnet; Q61116; -.
DR PhosphoSitePlus; Q61116; -.
DR jPOST; Q61116; -.
DR PaxDb; Q61116; -.
DR PRIDE; Q61116; -.
DR ProteomicsDB; 299574; -.
DR DNASU; 22755; -.
DR Ensembl; ENSMUST00000032696; ENSMUSP00000032696; ENSMUSG00000055305.
DR Ensembl; ENSMUST00000108438; ENSMUSP00000104077; ENSMUSG00000055305.
DR GeneID; 22755; -.
DR KEGG; mmu:22755; -.
DR UCSC; uc009fpe.1; mouse.
DR CTD; 22755; -.
DR MGI; MGI:107611; Zfp93.
DR VEuPathDB; HostDB:ENSMUSG00000055305; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163265; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q61116; -.
DR OMA; YICSICC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q61116; -.
DR TreeFam; TF350845; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 22755; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp93; mouse.
DR PRO; PR:Q61116; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q61116; protein.
DR Bgee; ENSMUSG00000055305; Expressed in undifferentiated genital tubercle and 122 other tissues.
DR Genevisible; Q61116; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..645
FT /note="Zinc finger protein 235"
FT /id="PRO_0000047475"
FT DOMAIN 8..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 285..307
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 621..643
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 112..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 85
FT /note="A -> P (in Ref. 2; BAC26187)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 645 AA; 73012 MW; 7459CD140F5AF469 CRC64;
MTKLQEMVTF RDVAVVFSEE ELGLLDAAQR KLYHDVMLEN FRNLLAVGCQ SPNKMAPLDT
TGIRCLPLGQ LPCWQMTSHD VNKLARAPED GINTPGKGPH LLEQCHSSCH WGAEQPSQAP
EDDGCLENLP SNHSSSSDNQ EFLSGRAQSS WSKAHFSERW NHEKHCPQTL VKTKSQLLAP
GVNILGCISH HDHNILHKRD KVPSSGDCDQ VIFPMTLLTQ HCVYREQKAY QCSRGQEVFS
DSPSLELHQQ TLLGKKSPVH STHKDTRHSP SVPIQPSVHP GRKRYWCHEC GKGFRQSSAL
QTHQRVHTGE KPYRCDSCGK GFSRSSDLNI HRRVHTGEKP YKCEVCGKGF TQWAHLQAHE
RIHTGEKPYK CGDCGKRFSC SSNLHTHQRV HTEEKPYECN ECGKRFSLSG NLDIHQRVHT
GEKPYKCEEC GKGFSSASSF QSHQRVHTGE KPFHCSVCGK NFSRSSHFLD HQRIHTGEKP
YRCEVCGKRF PWSLSLHSHQ SVHTGKKPYK CGECGKGFSH ASSLQAHHSV HTGEKPFKCN
VCQKQFSKTS NLQAHQRVHT GEKPYKCDTC GKAFSQKSSL QVHQRIHTGE KPFKCEECGK
EFRWSVGLSS HQRVHTGEKP YTCQQCGKGF SQASYFHMHQ RVHTI
