ZN236_HUMAN
ID ZN236_HUMAN Reviewed; 1845 AA.
AC Q9UL36; B2RTX9; Q9UL37;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Zinc finger protein 236;
GN Name=ZNF236;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), AND VARIANT VAL-613.
RC TISSUE=Kidney;
RX PubMed=10458916; DOI=10.1006/geno.1999.5897;
RA Holmes D.I., Wahab N.A., Mason R.M.;
RT "Cloning and characterization of ZNF236, a glucose-regulated kruppel-like
RT zinc-finger gene mapping to human chromosome 18q22-q23.";
RL Genomics 60:105-109(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-613.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), AND VARIANT VAL-613.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UL36; O43741: PRKAB2; NbExp=3; IntAct=EBI-23928087, EBI-1053424;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=Q9UL36-1; Sequence=Displayed;
CC Name=A;
CC IsoId=Q9UL36-2; Sequence=VSP_006907, VSP_006908;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Expression levels are highest in
CC skeletal muscle and brain, intermediate in heart, pancreas, and
CC placenta, and lowest in kidney, liver, and lung.
CC -!- MISCELLANEOUS: [Isoform A]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF085244; AAD55329.1; -; mRNA.
DR EMBL; AF085243; AAD55328.1; -; mRNA.
DR EMBL; AC027575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471117; EAW66587.1; -; Genomic_DNA.
DR EMBL; BC140859; AAI40860.1; -; mRNA.
DR CCDS; CCDS42447.1; -. [Q9UL36-1]
DR RefSeq; NP_001293018.1; NM_001306089.1.
DR RefSeq; NP_031371.3; NM_007345.3. [Q9UL36-1]
DR RefSeq; XP_011524467.1; XM_011526165.2. [Q9UL36-1]
DR AlphaFoldDB; Q9UL36; -.
DR SMR; Q9UL36; -.
DR BioGRID; 113558; 8.
DR IntAct; Q9UL36; 1.
DR STRING; 9606.ENSP00000253159; -.
DR iPTMnet; Q9UL36; -.
DR PhosphoSitePlus; Q9UL36; -.
DR BioMuta; ZNF236; -.
DR DMDM; 296453040; -.
DR EPD; Q9UL36; -.
DR jPOST; Q9UL36; -.
DR MassIVE; Q9UL36; -.
DR MaxQB; Q9UL36; -.
DR PaxDb; Q9UL36; -.
DR PeptideAtlas; Q9UL36; -.
DR PRIDE; Q9UL36; -.
DR ProteomicsDB; 84938; -. [Q9UL36-1]
DR ProteomicsDB; 84939; -. [Q9UL36-2]
DR Antibodypedia; 1786; 38 antibodies from 12 providers.
DR DNASU; 7776; -.
DR Ensembl; ENST00000253159.12; ENSP00000253159.8; ENSG00000130856.17. [Q9UL36-1]
DR Ensembl; ENST00000543926.6; ENSP00000444524.2; ENSG00000130856.17. [Q9UL36-2]
DR GeneID; 7776; -.
DR KEGG; hsa:7776; -.
DR UCSC; uc002lmi.4; human. [Q9UL36-1]
DR CTD; 7776; -.
DR DisGeNET; 7776; -.
DR GeneCards; ZNF236; -.
DR HGNC; HGNC:13028; ZNF236.
DR HPA; ENSG00000130856; Low tissue specificity.
DR MIM; 604760; gene.
DR neXtProt; NX_Q9UL36; -.
DR OpenTargets; ENSG00000130856; -.
DR PharmGKB; PA37606; -.
DR VEuPathDB; HostDB:ENSG00000130856; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156787; -.
DR HOGENOM; CLU_002361_0_0_1; -.
DR InParanoid; Q9UL36; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UL36; -.
DR TreeFam; TF350781; -.
DR PathwayCommons; Q9UL36; -.
DR SignaLink; Q9UL36; -.
DR BioGRID-ORCS; 7776; 348 hits in 1106 CRISPR screens.
DR ChiTaRS; ZNF236; human.
DR GenomeRNAi; 7776; -.
DR Pharos; Q9UL36; Tbio.
DR PRO; PR:Q9UL36; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9UL36; protein.
DR Bgee; ENSG00000130856; Expressed in sural nerve and 201 other tissues.
DR ExpressionAtlas; Q9UL36; baseline and differential.
DR Genevisible; Q9UL36; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IEP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 17.
DR SMART; SM00355; ZnF_C2H2; 30.
DR SUPFAM; SSF57667; SSF57667; 16.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 30.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 30.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1845
FT /note="Zinc finger protein 236"
FT /id="PRO_0000047476"
FT ZN_FING 37..59
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 66..88
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 93..115
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 121..143
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 153..175
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..276
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..308
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 482..504
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 510..532
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 538..560
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 566..588
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 657..679
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 685..707
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 713..735
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 741..763
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 967..989
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 995..1017
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1023..1045
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1051..1073
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1167..1189
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1195..1217
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1223..1245
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1251..1273
FT /note="C2H2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1657..1680
FT /note="C2H2-type 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1686..1708
FT /note="C2H2-type 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1722..1744
FT /note="C2H2-type 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1750..1772
FT /note="C2H2-type 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1778..1801
FT /note="C2H2-type 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 404..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1530..1558
FT /note="ELNTTSGSLPSTTPMSPSAISTQNLVMSS -> GSRSVQHSVGPQECGSVEA
FT LYLENSSDKT (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10458916"
FT /id="VSP_006907"
FT VAR_SEQ 1559..1845
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10458916"
FT /id="VSP_006908"
FT VARIANT 166
FT /note="S -> L (in dbSNP:rs2276211)"
FT /id="VAR_057410"
FT VARIANT 613
FT /note="I -> V (in dbSNP:rs608433)"
FT /evidence="ECO:0000269|PubMed:10458916,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_065094"
FT VARIANT 614
FT /note="P -> S (in dbSNP:rs8093707)"
FT /id="VAR_057411"
FT VARIANT 643
FT /note="S -> G (in dbSNP:rs3794873)"
FT /id="VAR_057412"
FT VARIANT 818
FT /note="A -> T (in dbSNP:rs3752078)"
FT /id="VAR_057413"
FT CONFLICT 1544
FT /note="M -> T (in Ref. 1; AAD55329)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1845 AA; 203704 MW; DEC98655EEC0DB09 CRC64;
MGLCGLLERC WLHHDPDGVL TLNAENTNYA YQVPNFHKCE ICLLSFPKES QFQRHMRDHE
RNDKPHRCDQ CPQTFNVEFN LTLHKCTHSG EDPTCPVCNK KFSRVASLKA HIMLHEKEEN
LICSECGDEF TLQSQLAVHM EEHRQELAGT RQHACKACKK EFETSSELKE HMKTHYKIRV
SSTRSYNRNI DRSGFTYSCP HCGKTFQKPS QLTRHIRIHT GERPFKCSEC GKAFNQKGAL
QTHMIKHTGE KPHACAFCPA AFSQKGNLQS HVQRVHSEVK NGPTYNCTEC SCVFKSLGSL
NTHISKMHMG GPQNSTSSTE TAHVLTATLF QTLPLQQTEA QATSASSQPS SQAVSDVIQQ
LLELSEPAPV ESGQSPQPGQ QLSITVGINQ DILQQALENS GLSSIPAAAH PNDSCHAKTS
APHAQNPDVS SVSNEQTDPT DAEQEKEQES PEKLDKKEKK MIKKKSPFLP GSIREENGVR
WHVCPYCAKE FRKPSDLVRH IRIHTHEKPF KCPQCFRAFA VKSTLTAHIK THTGIKAFKC
QYCMKSFSTS GSLKVHIRLH TGVRPFACPH CDKKFRTSGH RKTHIASHFK HTELRKMRHQ
RKPAKVRVGK TNIPVPDIPL QEPILITDLG LIQPIPKNQF FQSYFNNNFV NEADRPYKCF
YCHRAYKKSC HLKQHIRSHT GEKPFKCSQC GRGFVSAGVL KAHIRTHTGL KSFKCLICNG
AFTTGGSLRR HMGIHNDLRP YMCPYCQKTF KTSLNCKKHM KTHRYELAQQ LQQHQQAASI
DDSTVDQQSM QASTQMQVEI ESDELPQTAE VVAANPEAML DLEPQHVVGT EEAGLGQQLA
DQPLEADEDG FVAPQDPLRG HVDQFEEQSP AQQSFEPAGL PQGFTVTDTY HQQPQFPPVQ
QLQDSSTLES QALSTSFHQQ SLLQAPSSDG MNVTTRLIQE SSQEELDLQA QGSQFLEDNE
DQSRRSYRCD YCNKGFKKSS HLKQHVRSHT GEKPYKCKLC GRGFVSSGVL KSHEKTHTGV
KAFSCSVCNA SFTTNGSLTR HMATHMSMKP YKCPFCEEGF RTTVHCKKHM KRHQTVPSAV
SATGETEGGD ICMEEEEEHS DRNASRKSRP EVITFTEEET AQLAKIRPQE SATVSEKVLV
QSAAEKDRIS ELRDKQAELQ DEPKHANCCT YCPKSFKKPS DLVRHVRIHT GEKPYKCDEC
GKSFTVKSTL DCHVKTHTGQ KLFSCHVCSN AFSTKGSLKV HMRLHTGAKP FKCPHCELRF
RTSGRRKTHM QFHYKPDPKK ARKPMTRSSS EGLQPVNLLN SSSTDPNVFI MNNSVLTGQF
DQNLLQPGLV GQAILPASVS AGGDLTVSLT DGSLATLEGI QLQLAANLVG PNVQISGIDA
ASINNITLQI DPSILQQTLQ QGNLLAQQLT GEPGLAPQNS SLQTSDSTVP ASVVIQPISG
LSLQPTVTSA NLTIGPLSEQ DSVLTTNSSG TQDLTQVMTS QGLVSPSGGP HEITLTINNS
SLSQVLAQAA GPTATSSSGS PQEITLTISE LNTTSGSLPS TTPMSPSAIS TQNLVMSSSG
VGGDASVTLT LADTQGMLSG GLDTVTLNIT SQGQQFPALL TDPSLSGQGG AGSPQVILVS
HTPQSASAAC EEIAYQVAGV SGNLAPGNQP EKEGRAHQCL ECDRAFSSAA VLMHHSKEVH
GRERIHGCPV CRKAFKRATH LKEHMQTHQA GPSLSSQKPR VFKCDTCEKA FAKPSQLERH
SRIHTGERPF HCTLCEKAFN QKSALQVHMK KHTGERPYKC AYCVMGFTQK SNMKLHMKRA
HSYAGALQES AGHPEQDGEE LSRTLHLEEV VQEAAGEWQA LTHVF
