ZN239_MOUSE
ID ZN239_MOUSE Reviewed; 201 AA.
AC P24399; Q99J71;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 239;
DE Short=Zfp-239;
DE AltName: Full=Zinc finger protein MOK-2;
GN Name=Znf239; Synonyms=Mok-2, Mok2, Zfp239;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2104662; DOI=10.1128/mcb.10.1.418-421.1990;
RA Ernoult-Lange M., Kress M., Hamer D.;
RT "A gene that encodes a protein consisting solely of zinc finger domains is
RT preferentially expressed in transformed mouse cells.";
RL Mol. Cell. Biol. 10:418-421(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in transformed mouse
CC cells.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; M32057; AAA39729.1; -; mRNA.
DR EMBL; AK133328; BAE21606.1; -; mRNA.
DR EMBL; BC003315; AAH03315.1; -; mRNA.
DR CCDS; CCDS20466.1; -.
DR PIR; I57505; I57505.
DR RefSeq; NP_001001792.1; NM_001001792.1.
DR RefSeq; NP_032642.2; NM_008616.2.
DR AlphaFoldDB; P24399; -.
DR SMR; P24399; -.
DR STRING; 10090.ENSMUSP00000078374; -.
DR iPTMnet; P24399; -.
DR PhosphoSitePlus; P24399; -.
DR MaxQB; P24399; -.
DR PaxDb; P24399; -.
DR PRIDE; P24399; -.
DR Antibodypedia; 6019; 108 antibodies from 19 providers.
DR DNASU; 22685; -.
DR Ensembl; ENSMUST00000079405; ENSMUSP00000078374; ENSMUSG00000042097.
DR Ensembl; ENSMUST00000172088; ENSMUSP00000128270; ENSMUSG00000042097.
DR GeneID; 22685; -.
DR KEGG; mmu:22685; -.
DR UCSC; uc009dlc.1; mouse.
DR CTD; 22685; -.
DR MGI; MGI:1306812; Zfp239.
DR VEuPathDB; HostDB:ENSMUSG00000042097; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163366; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; P24399; -.
DR OMA; LRHANFH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P24399; -.
DR TreeFam; TF337055; -.
DR BioGRID-ORCS; 22685; 2 hits in 72 CRISPR screens.
DR PRO; PR:P24399; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P24399; protein.
DR Bgee; ENSMUSG00000042097; Expressed in ileal epithelium and 202 other tissues.
DR Genevisible; P24399; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..201
FT /note="Zinc finger protein 239"
FT /id="PRO_0000047481"
FT ZN_FING 6..28
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 34..56
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 62..84
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 90..112
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 118..140
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 146..168
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 174..196
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 27
FT /note="V -> L (in Ref. 1; AAA39729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 201 AA; 22818 MW; C7112D76DC7DC412 CRC64;
MAEKPYKCDK CGKGFTRSSS LLVHHSVHTG EKPFKCDRCG KGFSQSSKLH IHKRVHTGEK
PYACEECGMS FSQRSNLHIH QRVHTGERPY KCGECGKGFS QSSNLHIHRC THTGEKPYQC
YECGKGFSQS SDLRIHLRVH TGEKPYHCGK CGQGFSQSSK LLIHQRVHTG EKPYECSKCG
KGFSQSSNLH IHQRVHRKEL H
