ID   ZN248_PONAB             Reviewed;         578 AA.
AC   Q5REN4;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Zinc finger protein 248;
GN   Name=ZNF248;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; CR857488; CAH89773.1; -; mRNA.
DR   RefSeq; NP_001124811.1; NM_001131339.1.
DR   AlphaFoldDB; Q5REN4; -.
DR   SMR; Q5REN4; -.
DR   STRING; 9601.ENSPPYP00000002572; -.
DR   GeneID; 100436044; -.
DR   KEGG; pon:100436044; -.
DR   CTD; 57209; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q5REN4; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE   2: Evidence at transcript level;
KW   DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..578
FT                   /note="Zinc finger protein 248"
FT                   /id="PRO_0000290349"
FT   DOMAIN          8..78
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         239..263
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         379..401
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         407..429
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         435..457
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         463..485
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         491..513
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         519..542
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         547..569
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CROSSLNK        340
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NDW4"
SQ   SEQUENCE   578 AA;  66986 MW;  CBB60CF48696C7CC CRC64;
     MNKSQEQVSF KDVCVDFTQE EWYLLDPAQK ILYRDVILEN YSNLVSVGYC ITKPEVIFKI
     EQGEEPWILE KGFPSQDPER KWKVDDMLES SQENEDDHFW ELLFHNNKTV SVENGDRGSK
     TFNLGTDPVS LRNYPYKICD SCEMSLKNIS GLIISKKSCS RKKPDEFNVC EKLLLDIRHE
     KIPIGEKSYK YDQKRNAINY HQDLSQPSFG QSFEYSKNGQ GFHDEAAFFT NKRSQIGETV
     CKYNECGRTF IESLKLNISQ RPHLEMEPYG CSICGKSFCM NLRFGHQRAL TKDNPYEYNE
     YGEIFCDNSA FIIHQGAYTR KILREYKVSD KTWEKSTVLK HQIVHMGGKS YDYNENGSNF
     SKKSHLTQLR RAHTGEKTFE CGECGKTFWE KSNLTQHQRT HTGEKPYECT ECGKAFCQKP
     HLTNHQRTHT GEKPYECKQC GKTFCVKSNL TEHQRTHTGE KPYECNACGK SFCHRSALTV
     HQRTHTGEKP FICNECGKSF CVKSNLIVHQ RTHTGEKPYK CNECGKTFCE KSALTKHQRT
     HTGEKPYECN ACGKTFSQRS VLTKHQRIHM RVKALSTS