ZN260_HUMAN
ID ZN260_HUMAN Reviewed; 412 AA.
AC Q3ZCT1; Q0VF43;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Zinc finger protein 260;
DE Short=Zfp-260;
GN Name=ZNF260; Synonyms=ZFP260;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=16166646; DOI=10.1128/mcb.25.19.8669-8682.2005;
RA Debrus S., Rahbani L., Marttila M., Delorme B., Paradis P., Nemer M.;
RT "The zinc finger-only protein Zfp260 is a novel cardiac regulator and a
RT nuclear effector of alpha1-adrenergic signaling.";
RL Mol. Cell. Biol. 25:8669-8682(2005).
CC -!- FUNCTION: Transcription factor that acts as a cardiac regulator and an
CC effector of alpha1-adrenergic signaling. Binds to PE response elements
CC (PERE) present in the promoter of genes such as ANF/NPPA and acts as a
CC direct transcriptional activator of NPPA. Also acts as a cofactor with
CC GATA4, a key cardiac regulator (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA. Interacts with GATA4 (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q3ZCT1; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10241410, EBI-10172290;
CC Q3ZCT1; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-10241410, EBI-928842;
CC Q3ZCT1; Q5T619: ZNF648; NbExp=3; IntAct=EBI-10241410, EBI-11985915;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16166646}.
CC -!- INDUCTION: Up-regulated by activation of alpha1-adrenergic receptors.
CC {ECO:0000269|PubMed:16166646}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AC092295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042676; AAH42676.1; -; mRNA.
DR EMBL; BC119003; AAI19004.1; -; mRNA.
DR EMBL; BC122549; AAI22550.1; -; mRNA.
DR CCDS; CCDS33003.1; -.
DR RefSeq; NP_001012774.1; NM_001012756.2.
DR RefSeq; NP_001159508.1; NM_001166036.1.
DR RefSeq; NP_001159509.1; NM_001166037.1.
DR RefSeq; NP_001159510.1; NM_001166038.1.
DR RefSeq; XP_011525199.1; XM_011526897.2.
DR RefSeq; XP_016882230.1; XM_017026741.1.
DR AlphaFoldDB; Q3ZCT1; -.
DR SMR; Q3ZCT1; -.
DR BioGRID; 130868; 13.
DR IntAct; Q3ZCT1; 9.
DR STRING; 9606.ENSP00000429803; -.
DR iPTMnet; Q3ZCT1; -.
DR PhosphoSitePlus; Q3ZCT1; -.
DR BioMuta; ZNF260; -.
DR DMDM; 215274187; -.
DR EPD; Q3ZCT1; -.
DR jPOST; Q3ZCT1; -.
DR MassIVE; Q3ZCT1; -.
DR PaxDb; Q3ZCT1; -.
DR PeptideAtlas; Q3ZCT1; -.
DR PRIDE; Q3ZCT1; -.
DR ProteomicsDB; 61911; -.
DR Antibodypedia; 48040; 48 antibodies from 11 providers.
DR DNASU; 339324; -.
DR Ensembl; ENST00000523638.6; ENSP00000429803.1; ENSG00000254004.7.
DR Ensembl; ENST00000588993.1; ENSP00000467219.1; ENSG00000254004.7.
DR Ensembl; ENST00000592282.1; ENSP00000464964.1; ENSG00000254004.7.
DR Ensembl; ENST00000593142.5; ENSP00000465834.1; ENSG00000254004.7.
DR GeneID; 339324; -.
DR KEGG; hsa:339324; -.
DR MANE-Select; ENST00000523638.6; ENSP00000429803.1; NM_001166037.2; NP_001159509.1.
DR UCSC; uc002oee.3; human.
DR CTD; 339324; -.
DR DisGeNET; 339324; -.
DR GeneCards; ZNF260; -.
DR HGNC; HGNC:13499; ZNF260.
DR HPA; ENSG00000254004; Low tissue specificity.
DR MIM; 613749; gene.
DR neXtProt; NX_Q3ZCT1; -.
DR OpenTargets; ENSG00000254004; -.
DR PharmGKB; PA145147548; -.
DR VEuPathDB; HostDB:ENSG00000254004; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162468; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q3ZCT1; -.
DR OMA; FSQKSHY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3ZCT1; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q3ZCT1; -.
DR SignaLink; Q3ZCT1; -.
DR BioGRID-ORCS; 339324; 10 hits in 1079 CRISPR screens.
DR ChiTaRS; ZNF260; human.
DR GenomeRNAi; 339324; -.
DR Pharos; Q3ZCT1; Tdark.
DR PRO; PR:Q3ZCT1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q3ZCT1; protein.
DR Bgee; ENSG00000254004; Expressed in oviduct epithelium and 189 other tissues.
DR Genevisible; Q3ZCT1; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..412
FT /note="Zinc finger protein 260"
FT /id="PRO_0000047320"
FT ZN_FING 27..49
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 55..77
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 83..105
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 136..158
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 164..186
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 192..214
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 220..242
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 248..270
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 276..298
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..326
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..412
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 412 AA; 47222 MW; D3943F148FD9C77C CRC64;
MIGMLESLQH ESDLLQHDQI HTGEKPYECN ECRKTFSLKQ NLVEHKKMHT GEKSHECTEC
GKVCSRVSSL TLHLRSHTGK KAYKCNKCGK AFSQKENFLS HQKHHTGEKP YECEKVSIQM
PTIIRHQKNH TGTKPYACKE CGKAFNGKAY LTEHEKIHTG EKPFECNQCG RAFSQKQYLI
KHQNIHTGKK PFKCSECGKA FSQKENLIIH QRIHTGEKPY ECKGCGKAFI QKSSLIRHQR
SHTGEKPYTC KECGKAFSGK SNLTEHEKIH IGEKPYKCNE CGTIFRQKQY LIKHHNIHTG
EKPYECNKCG KAFSRITSLI VHVRIHTGDK PYECKVCGKA FCQSSSLTVH MRSHTGEKPY
GCNECGKAFS QFSTLALHMR IHTGEKPYQC SECGKAFSQK SHHIRHQRIH TH
