ZN260_RAT
ID ZN260_RAT Reviewed; 407 AA.
AC Q62981; Q499Q6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 260;
DE Short=Zfp-260;
DE AltName: Full=Pancreas-only zinc finger protein 1;
DE Short=POZF-1;
GN Name=Znf260; Synonyms=Pex1, Zfp260;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Pancreas;
RA Urrutia R., Mesa K., Gebelein B.;
RT "Novel pancreas enriched zinc finger encoding gene.";
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, INDUCTION, AND INTERACTION WITH GATA4.
RX PubMed=16166646; DOI=10.1128/mcb.25.19.8669-8682.2005;
RA Debrus S., Rahbani L., Marttila M., Delorme B., Paradis P., Nemer M.;
RT "The zinc finger-only protein Zfp260 is a novel cardiac regulator and a
RT nuclear effector of alpha1-adrenergic signaling.";
RL Mol. Cell. Biol. 25:8669-8682(2005).
CC -!- FUNCTION: Transcription factor that acts as a cardiac regulator and an
CC effector of alpha1-adrenergic signaling. Binds to PE response elements
CC (PERE) present in the promoter of genes such as ANF/NPPA and acts as a
CC direct transcriptional activator of NPPA. Also acts as a cofactor with
CC GATA4, a key cardiac regulator. {ECO:0000269|PubMed:16166646}.
CC -!- SUBUNIT: Binds DNA. Interacts with GATA4.
CC {ECO:0000269|PubMed:16166646}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16166646}.
CC -!- TISSUE SPECIFICITY: Expressed in both embryonic, fetal and adult heart.
CC Also expressed in lung, skeletal muscle and adrenal glands.
CC {ECO:0000269|PubMed:16166646}.
CC -!- DEVELOPMENTAL STAGE: Expressed in cardiomyocytes from E14.
CC {ECO:0000269|PubMed:16166646}.
CC -!- INDUCTION: Up-regulated by activation of alpha1-adrenergic receptors.
CC {ECO:0000269|PubMed:16166646}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U56862; AAB01227.1; -; mRNA.
DR EMBL; BC099805; AAH99805.1; -; mRNA.
DR RefSeq; NP_059060.1; NM_017364.4.
DR AlphaFoldDB; Q62981; -.
DR SMR; Q62981; -.
DR STRING; 10116.ENSRNOP00000047459; -.
DR PaxDb; Q62981; -.
DR Ensembl; ENSRNOT00000049877; ENSRNOP00000047459; ENSRNOG00000020762.
DR Ensembl; ENSRNOT00000074301; ENSRNOP00000065656; ENSRNOG00000020762.
DR Ensembl; ENSRNOT00000103714; ENSRNOP00000088893; ENSRNOG00000020762.
DR Ensembl; ENSRNOT00000113539; ENSRNOP00000087535; ENSRNOG00000020762.
DR GeneID; 53982; -.
DR KEGG; rno:53982; -.
DR CTD; 26466; -.
DR RGD; 621205; Zfp260.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162468; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q62981; -.
DR OMA; FSQKSHY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q62981; -.
DR TreeFam; TF341817; -.
DR PRO; PR:Q62981; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000020762; Expressed in Ammon's horn and 20 other tissues.
DR Genevisible; Q62981; RN.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..407
FT /note="Zinc finger protein 260"
FT /id="PRO_0000047322"
FT ZN_FING 23..45
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 51..73
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 79..101
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 131..153
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 159..181
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 187..209
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 215..237
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 46584 MW; FA6FB32E67A33BF6 CRC64;
MLESLQPESE LLHDEPDPGE KVYECDECRK TFSLEQHFVE HKKTHGGEKS PECTGCGEEF
SKASSLTRHL RSRSRRESYK CGNCGRTFSQ RGNFLSHQKQ HAEERPSESK KTPVPMTTIV
RNQRNAGNKP YACKECGKAF NGKSYLKEHE KIHTGEKPFE CNQCGRAFSQ KQYLIKHQNV
HSGKKPFKCN ECGKAFSQKE NLIIHQRIHT GEKPYECKGC GKAFIQKSSL IRHQRSHTGE
KPYTCKECGK AFSGKSNLTE HEKIHIGEKP YKCNECGTIF RQKQYLIKHH NIHTGEKPYE
CNKCGKAFSR ITSLIVHVRI HTGDKPYECK VCGKAFCQSS SLTVHMRSHT GEKPYGCNEC
GKAFSQFSTL ALHMRIHTGE KPYQCSECGK AFSQKSHHIR HQRIHIH
