ZN266_HUMAN
ID ZN266_HUMAN Reviewed; 549 AA.
AC Q14584; A0AV90; A4FU85; Q6IQ07; Q6U8A5; Q8IVG3; Q8WVX1; Q96SX9;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 197.
DE RecName: Full=Zinc finger protein 266;
DE AltName: Full=Zinc finger protein HZF1;
GN Name=ZNF266; Synonyms=KIAA2007;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Lu L., Huang X.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M., Sha J.H.;
RT "Cloning of a new isoform of KIAA2007 protein in testis.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Embryonic stem cell, Eye, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 159-549.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 350-549.
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q14584; Q8NHQ1: CEP70; NbExp=6; IntAct=EBI-7115319, EBI-739624;
CC Q14584; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-7115319, EBI-3867333;
CC Q14584; Q6A162: KRT40; NbExp=5; IntAct=EBI-7115319, EBI-10171697;
CC Q14584; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-7115319, EBI-10172290;
CC Q14584; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-7115319, EBI-10171774;
CC Q14584; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-7115319, EBI-3958099;
CC Q14584; Q99750: MDFI; NbExp=6; IntAct=EBI-7115319, EBI-724076;
CC Q14584; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-7115319, EBI-10172526;
CC Q14584; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-7115319, EBI-11522433;
CC Q14584; Q8WV44: TRIM41; NbExp=6; IntAct=EBI-7115319, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK027480; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AK027480; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC23104.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY376240; AAQ82907.1; -; mRNA.
DR EMBL; AB095928; BAC23104.1; ALT_INIT; mRNA.
DR EMBL; BC017407; AAH17407.2; -; mRNA.
DR EMBL; BC071628; AAH71628.1; -; mRNA.
DR EMBL; BC112919; AAI12920.1; -; mRNA.
DR EMBL; BC146837; AAI46838.1; -; mRNA.
DR EMBL; BC126255; AAI26256.1; -; mRNA.
DR EMBL; AK027480; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; X78924; CAA55524.1; -; mRNA.
DR CCDS; CCDS12213.1; -.
DR PIR; S47067; S47067.
DR RefSeq; NP_001258243.1; NM_001271314.1.
DR RefSeq; NP_006622.2; NM_006631.3.
DR RefSeq; XP_005259773.1; XM_005259716.3.
DR RefSeq; XP_006722690.1; XM_006722627.2.
DR RefSeq; XP_006722693.1; XM_006722630.2.
DR RefSeq; XP_011525949.1; XM_011527647.1.
DR RefSeq; XP_011525950.1; XM_011527648.1.
DR RefSeq; XP_011525952.1; XM_011527650.1.
DR RefSeq; XP_016881645.1; XM_017026156.1.
DR RefSeq; XP_016881646.1; XM_017026157.1.
DR RefSeq; XP_016881647.1; XM_017026158.1.
DR RefSeq; XP_016881648.1; XM_017026159.1.
DR RefSeq; XP_016881649.1; XM_017026160.1.
DR RefSeq; XP_016881650.1; XM_017026161.1.
DR RefSeq; XP_016881651.1; XM_017026162.1.
DR RefSeq; XP_016881652.1; XM_017026163.1.
DR RefSeq; XP_016881653.1; XM_017026164.1.
DR RefSeq; XP_016881654.1; XM_017026165.1.
DR RefSeq; XP_016881655.1; XM_017026166.1.
DR RefSeq; XP_016881656.1; XM_017026167.1.
DR AlphaFoldDB; Q14584; -.
DR SMR; Q14584; -.
DR BioGRID; 115998; 16.
DR IntAct; Q14584; 13.
DR MINT; Q14584; -.
DR STRING; 9606.ENSP00000466714; -.
DR iPTMnet; Q14584; -.
DR PhosphoSitePlus; Q14584; -.
DR BioMuta; ZNF266; -.
DR DMDM; 85681859; -.
DR jPOST; Q14584; -.
DR MassIVE; Q14584; -.
DR MaxQB; Q14584; -.
DR PaxDb; Q14584; -.
DR PeptideAtlas; Q14584; -.
DR PRIDE; Q14584; -.
DR ProteomicsDB; 60057; -.
DR Antibodypedia; 12591; 176 antibodies from 24 providers.
DR DNASU; 10781; -.
DR Ensembl; ENST00000588221.5; ENSP00000468491.1; ENSG00000174652.20.
DR Ensembl; ENST00000588933.5; ENSP00000467151.1; ENSG00000174652.20.
DR Ensembl; ENST00000590306.5; ENSP00000467315.1; ENSG00000174652.20.
DR Ensembl; ENST00000592292.5; ENSP00000467403.1; ENSG00000174652.20.
DR Ensembl; ENST00000651268.1; ENSP00000498589.1; ENSG00000174652.20.
DR GeneID; 10781; -.
DR KEGG; hsa:10781; -.
DR UCSC; uc002mlo.5; human.
DR CTD; 10781; -.
DR DisGeNET; 10781; -.
DR GeneCards; ZNF266; -.
DR HGNC; HGNC:13059; ZNF266.
DR HPA; ENSG00000174652; Low tissue specificity.
DR MIM; 604751; gene.
DR neXtProt; NX_Q14584; -.
DR OpenTargets; ENSG00000174652; -.
DR PharmGKB; PA37637; -.
DR VEuPathDB; HostDB:ENSG00000174652; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162380; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q14584; -.
DR OMA; KKPYTCM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14584; -.
DR TreeFam; TF342172; -.
DR PathwayCommons; Q14584; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q14584; -.
DR BioGRID-ORCS; 10781; 5 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF266; human.
DR GenomeRNAi; 10781; -.
DR Pharos; Q14584; Tbio.
DR PRO; PR:Q14584; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q14584; protein.
DR Bgee; ENSG00000174652; Expressed in granulocyte and 199 other tissues.
DR ExpressionAtlas; Q14584; baseline and differential.
DR Genevisible; Q14584; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..549
FT /note="Zinc finger protein 266"
FT /id="PRO_0000047493"
FT DOMAIN 1..42
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 156..178
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 530..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..549
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 519
FT /note="P -> L (in dbSNP:rs10515)"
FT /id="VAR_014828"
FT CONFLICT 257
FT /note="Q -> E (in Ref. 3; AAH17407)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 549 AA; 62116 MW; 59670F5DF8CFD81F CRC64;
MLENYKNLAT VGYQLFKPSL ISWLEQEESR TVQRGDFQAS EWKVQLKTKE LALQQDVLGE
PTSSGIQMIG SHNGGEVSDV KQCGDVSSEH SCLKTHVRTQ NSENTFECYL YGVDFLTLHK
KTSTGEQRSV FSQCGKAFSL NPDVVCQRTC TGEKAFDCSD SGKSFINHSH LQGHLRTHNG
ESLHEWKECG RGFIHSTDLA VRIQTHRSEK PYKCKECGKG FRYSAYLNIH MGTHTGDNPY
ECKECGKAFT RSCQLTQHRK THTGEKPYKC KDCGRAFTVS SCLSQHMKIH VGEKPYECKE
CGIAFTRSSQ LTEHLKTHTA KDPFECKICG KSFRNSSCLS DHFRIHTGIK PYKCKDCGKA
FTQNSDLTKH ARTHSGERPY ECKECGKAFA RSSRLSEHTR THTGEKPFEC VKCGKAFAIS
SNLSGHLRIH TGEKPFECLE CGKAFTHSSS LNNHMRTHSA KKPFTCMECG KAFKFPTCVN
LHMRIHTGEK PYKCKQCGKS FSYSNSFQLH ERTHTGEKPY ECKECGKAFS SSSSFRNHER
RHADERLSA
