ZN267_HUMAN
ID ZN267_HUMAN Reviewed; 743 AA.
AC Q14586; A0JNZ9; Q8NE41; Q9NRJ0;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 212.
DE RecName: Full=Zinc finger protein 267;
DE AltName: Full=Zinc finger protein HZF2;
GN Name=ZNF267;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TYR-350.
RA Schaefer U., Schneider A., Neugebauer E.;
RT "Identification of a nitric oxide regulated krueppel-like zinc finger
RT protein using motif directed differential display.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-350.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-350.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-743, AND VARIANT TYR-350.
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
RN [5]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-66, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA Vertegaal A.C.;
RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL Cell Rep. 10:1778-1791(2015).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-66 AND LYS-135, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF220492; AAF73867.1; -; mRNA.
DR EMBL; AK292573; BAF85262.1; -; mRNA.
DR EMBL; BC036367; AAH36367.1; -; mRNA.
DR EMBL; BC127088; AAI27089.1; -; mRNA.
DR EMBL; BC127089; AAI27090.1; -; mRNA.
DR EMBL; X78925; CAA55525.1; -; mRNA.
DR CCDS; CCDS32440.1; -.
DR PIR; S47073; S47073.
DR RefSeq; NP_001252517.1; NM_001265588.1.
DR RefSeq; NP_003405.3; NM_003414.5.
DR AlphaFoldDB; Q14586; -.
DR SMR; Q14586; -.
DR BioGRID; 115594; 11.
DR IntAct; Q14586; 9.
DR STRING; 9606.ENSP00000300870; -.
DR iPTMnet; Q14586; -.
DR PhosphoSitePlus; Q14586; -.
DR BioMuta; ZNF267; -.
DR DMDM; 296453069; -.
DR EPD; Q14586; -.
DR jPOST; Q14586; -.
DR MassIVE; Q14586; -.
DR MaxQB; Q14586; -.
DR PaxDb; Q14586; -.
DR PeptideAtlas; Q14586; -.
DR PRIDE; Q14586; -.
DR ProteomicsDB; 60059; -.
DR Antibodypedia; 833; 27 antibodies from 12 providers.
DR DNASU; 10308; -.
DR Ensembl; ENST00000300870.15; ENSP00000300870.10; ENSG00000185947.15.
DR GeneID; 10308; -.
DR KEGG; hsa:10308; -.
DR MANE-Select; ENST00000300870.15; ENSP00000300870.10; NM_003414.6; NP_003405.4.
DR UCSC; uc002ecs.6; human.
DR CTD; 10308; -.
DR DisGeNET; 10308; -.
DR GeneCards; ZNF267; -.
DR HGNC; HGNC:13060; ZNF267.
DR HPA; ENSG00000185947; Low tissue specificity.
DR MIM; 604752; gene.
DR neXtProt; NX_Q14586; -.
DR OpenTargets; ENSG00000185947; -.
DR PharmGKB; PA37638; -.
DR VEuPathDB; HostDB:ENSG00000185947; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164593; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; Q14586; -.
DR OMA; RHGNCDL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14586; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q14586; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q14586; -.
DR SIGNOR; Q14586; -.
DR BioGRID-ORCS; 10308; 25 hits in 1096 CRISPR screens.
DR GeneWiki; ZNF267; -.
DR GenomeRNAi; 10308; -.
DR Pharos; Q14586; Tdark.
DR PRO; PR:Q14586; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q14586; protein.
DR Bgee; ENSG00000185947; Expressed in oocyte and 194 other tissues.
DR ExpressionAtlas; Q14586; baseline and differential.
DR Genevisible; Q14586; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..743
FT /note="Zinc finger protein 267"
FT /id="PRO_0000047494"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 267..289
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 322..340
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 548..570
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 576..598
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 604..626
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 632..654
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 660..682
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 688..710
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 716..738
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 66
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25772364,
FT ECO:0007744|PubMed:28112733"
FT CROSSLNK 135
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 257
FT /note="M -> V (in dbSNP:rs7202455)"
FT /id="VAR_057414"
FT VARIANT 350
FT /note="C -> Y (in dbSNP:rs3850114)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:7865130,
FT ECO:0000269|Ref.1"
FT /id="VAR_059907"
FT CONFLICT 31
FT /note="D -> N (in Ref. 3; AAH36367)"
FT /evidence="ECO:0000305"
FT CONFLICT 567
FT /note="H -> Y (in Ref. 1; AAF73867 and 4; CAA55525)"
FT /evidence="ECO:0000305"
FT CONFLICT 592
FT /note="T -> S (in Ref. 1; AAF73867 and 4; CAA55525)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 743 AA; 87376 MW; 66AA4EC827BEFAAF CRC64;
MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP DLITFLEQRK
EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS RRHGSCDLEN LHLRKRWKRE
ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ QILSSCAKSY NFDQYRKVFT HSSLLNQQEE
IDIWGKHHIY DKTSVLFRQV STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL
EKQYKCKEFE EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY
DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC KWKECGKVFN
LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR IHTGEKPYKC KECGKAFRCS
SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC LTQHQTTHTG EKLYKCKVCS KSYARSSNLI
MHQRVHTGEK PYKCKECGKV FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER
IHTGEKPYKC KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG
EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH QRSHTGERPY
KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR SYLTTHRRSH SGERPYKCEE
CGKAFNSRSY LIAHQRSHTR EKL
