ZN271_MOUSE
ID ZN271_MOUSE Reviewed; 580 AA.
AC P15620;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Zinc finger protein 271;
DE AltName: Full=Zinc finger protein 35;
DE Short=Zfp-35;
GN Name=Znf271; Synonyms=Zfp-35, Zfp35;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=MF1; TISSUE=Testis;
RX PubMed=2104800; DOI=10.1002/j.1460-2075.1990.tb08096.x;
RA Cunliffe V.T., Koopman P., McLaren A., Trowsdale J.;
RT "A mouse zinc finger gene which is transiently expressed during
RT spermatogenesis.";
RL EMBO J. 9:197-205(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2249852; DOI=10.1016/0888-7543(90)90290-b;
RA Cunliffe V., Williams S., Trowsdale J.;
RT "Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-regulated
RT during spermatogenesis.";
RL Genomics 8:331-339(1990).
CC -!- FUNCTION: May act to control gene activity during the pachytene stage
CC of meiotic prophase. May function as a transcription activator.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Selectively expressed in adult testis.
CC {ECO:0000269|PubMed:2104800}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; X17617; CAA35618.1; -; mRNA.
DR EMBL; M36146; AAA40583.1; -; Genomic_DNA.
DR EMBL; M36145; AAA40583.1; JOINED; Genomic_DNA.
DR CCDS; CCDS29097.1; -.
DR PIR; A37107; A37107.
DR RefSeq; NP_035885.2; NM_011755.2.
DR AlphaFoldDB; P15620; -.
DR SMR; P15620; -.
DR BioGRID; 204657; 1.
DR STRING; 10090.ENSMUSP00000074475; -.
DR iPTMnet; P15620; -.
DR PhosphoSitePlus; P15620; -.
DR PaxDb; P15620; -.
DR PRIDE; P15620; -.
DR ProteomicsDB; 275279; -.
DR DNASU; 22694; -.
DR Ensembl; ENSMUST00000074941; ENSMUSP00000074475; ENSMUSG00000063281.
DR GeneID; 22694; -.
DR KEGG; mmu:22694; -.
DR UCSC; uc008egk.1; mouse.
DR CTD; 22694; -.
DR MGI; MGI:99179; Zfp35.
DR VEuPathDB; HostDB:ENSMUSG00000063281; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162441; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P15620; -.
DR OMA; YGQSFVW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P15620; -.
DR TreeFam; TF341817; -.
DR BioGRID-ORCS; 22694; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp35; mouse.
DR PRO; PR:P15620; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; P15620; protein.
DR Bgee; ENSMUSG00000063281; Expressed in floor plate of midbrain and 246 other tissues.
DR ExpressionAtlas; P15620; baseline and differential.
DR Genevisible; P15620; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IMP:MGI.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IMP:MGI.
DR GO; GO:0002829; P:negative regulation of type 2 immune response; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 16.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Spermatogenesis;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..580
FT /note="Zinc finger protein 271"
FT /id="PRO_0000047497"
FT ZN_FING 78..100
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 104..126
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 132..154
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 160..182
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 188..210
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 216..238
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 244..266
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 272..294
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 300..322
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 328..350
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 356..378
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 384..406
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 412..434
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 440..462
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 468..490
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 496..518
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 524..545
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 551..573
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 370
FT /note="D -> H (in Ref. 2; AAA40583)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 67036 MW; 11AA449913562B4C CRC64;
MEIQFSYESQ DHHFLSDGET KIKIGEPATE EEMTGKIGTV TEESGSLEED VPHDSRGKEF
REFGEELNDQ MLFRRRQYNC DECDQSFAWS TGLIRHQRTH WKPYECEECG KAFRMSSALV
LHQRIHTGEK PYPCSWCIKS FSRSSDLIKH QRVHTGEKPY KCDECGKAFS QSSDLMIHQR
IHTGEKPYQC SHCSKSFSQH SGMVKHLRIH TGEKPYMCNH CYKHFSQSSD LIKHQRIHTG
EKPYKCDVCG KAFSQSSDRI LHQRIHTGEK PYPCAQCNKS FSQNSDLIKH RRIHTGEKPY
KCSECGKAFN QSSVLILHQR IHTGEKPYPC NQCTKSFSRL SDLINHQRIH TGEKPYPCSQ
CSKMFSRRSD LVKHYRIHTG EKPYECDKCG KTFSQSSNLI LHQRIHTGEK PYPCNSCSKS
FSRGSDLIKH QRVHTGEKPY TCNLCSKSFS QSSDLTKHQR VHSGEKPYHC SSCNKAFRQS
SDLILHHRVH TGERPYACTQ CPRSFSQKSD LIKHQRIHTG EKPYKCMCGK AFSQCSAFTL
HQRIHTGEKP YPCAQCGKSF SQRSDLVNHQ RVHADQKLQM
