ZN273_HUMAN
ID ZN273_HUMAN Reviewed; 569 AA.
AC Q14593; B3KQZ5; Q6P3V4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Zinc finger protein 273;
DE AltName: Full=Zinc finger protein HZF9;
GN Name=ZNF273;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 322-569 (ISOFORMS 1/2), AND VARIANT ASP-461.
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q14593; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-3922471, EBI-10172150;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14593-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14593-2; Sequence=VSP_038180;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK090648; BAG52207.1; -; mRNA.
DR EMBL; DA094186; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC092161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471204; EAW77994.1; -; Genomic_DNA.
DR EMBL; BC063818; AAH63818.1; -; mRNA.
DR EMBL; X78932; CAA55532.1; -; mRNA.
DR CCDS; CCDS5528.2; -. [Q14593-1]
DR PIR; S47070; S47070.
DR RefSeq; NP_066971.2; NM_021148.2. [Q14593-1]
DR RefSeq; XP_016867177.1; XM_017011688.1.
DR RefSeq; XP_016867178.1; XM_017011689.1.
DR RefSeq; XP_016867179.1; XM_017011690.1.
DR RefSeq; XP_016867180.1; XM_017011691.1.
DR RefSeq; XP_016867181.1; XM_017011692.1.
DR RefSeq; XP_016867182.1; XM_017011693.1.
DR RefSeq; XP_016867183.1; XM_017011694.1.
DR RefSeq; XP_016867184.1; XM_017011695.1.
DR RefSeq; XP_016867185.1; XM_017011696.1.
DR RefSeq; XP_016867186.1; XM_017011697.1.
DR RefSeq; XP_016867187.1; XM_017011698.1.
DR AlphaFoldDB; Q14593; -.
DR SMR; Q14593; -.
DR BioGRID; 116008; 22.
DR IntAct; Q14593; 12.
DR STRING; 9606.ENSP00000418719; -.
DR iPTMnet; Q14593; -.
DR PhosphoSitePlus; Q14593; -.
DR BioMuta; ZNF273; -.
DR DMDM; 259016458; -.
DR jPOST; Q14593; -.
DR MassIVE; Q14593; -.
DR MaxQB; Q14593; -.
DR PaxDb; Q14593; -.
DR PeptideAtlas; Q14593; -.
DR PRIDE; Q14593; -.
DR ProteomicsDB; 60068; -. [Q14593-1]
DR ProteomicsDB; 60069; -. [Q14593-2]
DR Antibodypedia; 55900; 29 antibodies from 9 providers.
DR DNASU; 10793; -.
DR Ensembl; ENST00000476120.2; ENSP00000418719.1; ENSG00000198039.12. [Q14593-1]
DR GeneID; 10793; -.
DR KEGG; hsa:10793; -.
DR MANE-Select; ENST00000476120.2; ENSP00000418719.1; NM_021148.3; NP_066971.2.
DR UCSC; uc003tto.4; human. [Q14593-1]
DR CTD; 10793; -.
DR DisGeNET; 10793; -.
DR GeneCards; ZNF273; -.
DR HGNC; HGNC:13067; ZNF273.
DR HPA; ENSG00000198039; Tissue enhanced (skin).
DR MIM; 604756; gene.
DR neXtProt; NX_Q14593; -.
DR OpenTargets; ENSG00000198039; -.
DR PharmGKB; PA37643; -.
DR VEuPathDB; HostDB:ENSG00000198039; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q14593; -.
DR OMA; RHAMVVK; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14593; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q14593; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q14593; -.
DR BioGRID-ORCS; 10793; 78 hits in 1019 CRISPR screens.
DR ChiTaRS; ZNF273; human.
DR GenomeRNAi; 10793; -.
DR Pharos; Q14593; Tdark.
DR PRO; PR:Q14593; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q14593; protein.
DR Bgee; ENSG00000198039; Expressed in right uterine tube and 163 other tissues.
DR ExpressionAtlas; Q14593; baseline and differential.
DR Genevisible; Q14593; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..569
FT /note="Zinc finger protein 273"
FT /id="PRO_0000047500"
FT DOMAIN 66..108
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 206..228
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 234..256
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 262..284
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 290..312
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 318..340
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 346..368
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 374..396
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 402..423
FT /note="C2H2-type 8; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 430..452
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 458..480
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 486..508
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 514..536
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 542..564
FT /note="C2H2-type 13; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..65
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_038180"
FT VARIANT 454
FT /note="G -> E (in dbSNP:rs1830080)"
FT /id="VAR_059077"
FT VARIANT 461
FT /note="E -> D (in dbSNP:rs2017252)"
FT /evidence="ECO:0000269|PubMed:7865130"
FT /id="VAR_059078"
FT CONFLICT 418
FT /note="Missing (in Ref. 5; CAA55532)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 569 AA; 64971 MW; D07D8C3B2AF81EEF CRC64;
MSSAPRGPPS VAPLPAGIGR STAKTPGLPG SLEMGPLTFR DVAIEFSLEE WQCLDTSQQN
LYRNVMLDNY RNLVFLGIAV SKPDLITCLE QGKEPCNMKR HAMVAKPPVV CSHFAQDLWP
KQGLKDSFQK VILRRYGKYG HENLQLRKGC KSADEHKVHK RGYNGLNQCL TTTQSKIFQC
DKYVKVLHKF SNSNIHKKRQ TGKKPFKCKE CGKSCCILSQ LTQHKKTATR VNFYKCKTCG
KAFNQFSNLT KHKIIHPEVN PYKCEECGKA FNQSLTLTKH KKIHTEEKPY KCEDCGKVFS
VFSVLTKHKI IHTGTKPYNC EECGKGFSIF STLTKHKIIH TGEKPYKCNE CGKAFNWSST
LTKHKRIHTG EKPYKCEECG KAFNQSSTLT RHKIVHTGEK PYKCEECGKA FKRSTTLTKH
KRIYTKEKPY KCEECGKAFS VFSTLTKHKI IHTGAKPYKC EECGSAFRAF STLTEHKRVH
TGEKPYKCNE CGKAFNWSST LTKHKRIHTG EKPYKCEECG KAFNRSSNLT RHKKIHTGEK
PYKPKRCDSA FDNTPNFSRH KRNHMGEKS
