ZN276_HUMAN
ID ZN276_HUMAN Reviewed; 614 AA.
AC Q8N554; Q0VGA1; Q2TBE8; Q3B7H7;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 4.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 276;
DE Short=Zfp-276;
DE AltName: Full=Zinc finger protein 477;
GN Name=ZNF276; Synonyms=CENP-Z, ZFP276, ZNF477;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS ARG-263; TRP-275;
RP TRP-351 AND ASP-605.
RX PubMed=14605947; DOI=10.1007/s10038-003-0088-1;
RA Wong J.C., Gokgoz N., Alon N., Andrulis I.L., Buchwald M.;
RT "Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in
RT breast cancer.";
RL J. Hum. Genet. 48:668-671(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 64-614 (ISOFORM 1), AND VARIANT ARG-263.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-351 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L., Wood L.,
RA Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P., Fukagawa T.,
RA Earnshaw W.C., Rappsilber J.;
RT "The protein composition of mitotic chromosomes determined using
RT multiclassifier combinatorial proteomics.";
RL Cell 142:810-821(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N554; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-750821, EBI-541426;
CC Q8N554; P54253: ATXN1; NbExp=4; IntAct=EBI-750821, EBI-930964;
CC Q8N554; Q16543: CDC37; NbExp=3; IntAct=EBI-750821, EBI-295634;
CC Q8N554; Q96Q77: CIB3; NbExp=3; IntAct=EBI-750821, EBI-10292696;
CC Q8N554; Q3B820: FAM161A; NbExp=3; IntAct=EBI-750821, EBI-719941;
CC Q8N554; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-750821, EBI-16439278;
CC Q8N554; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-750821, EBI-10288852;
CC Q8N554; P16118: PFKFB1; NbExp=3; IntAct=EBI-750821, EBI-709807;
CC Q8N554; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-750821, EBI-79165;
CC Q8N554; P49903: SEPHS1; NbExp=3; IntAct=EBI-750821, EBI-714091;
CC Q8N554; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-750821, EBI-11955057;
CC Q8N554; Q96BR9: ZBTB8A; NbExp=7; IntAct=EBI-750821, EBI-742740;
CC Q8N554-2; Q96CN9: GCC1; NbExp=3; IntAct=EBI-10265849, EBI-746252;
CC Q8N554-2; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-10265849, EBI-742740;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, centromere,
CC kinetochore {ECO:0000269|PubMed:20813266}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N554-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N554-2; Sequence=VSP_026104;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH32781.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI10349.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF354755; AAQ15128.1; -; mRNA.
DR EMBL; AF354756; AAQ15129.1; -; mRNA.
DR EMBL; AC005360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032781; AAH32781.2; ALT_INIT; mRNA.
DR EMBL; BC107603; AAI07604.1; -; mRNA.
DR EMBL; BC110348; AAI10349.1; ALT_INIT; mRNA.
DR EMBL; AK026482; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS10986.1; -. [Q8N554-2]
DR CCDS; CCDS45554.1; -. [Q8N554-1]
DR RefSeq; NP_001106997.1; NM_001113525.1. [Q8N554-1]
DR RefSeq; NP_689500.2; NM_152287.3. [Q8N554-2]
DR AlphaFoldDB; Q8N554; -.
DR SMR; Q8N554; -.
DR BioGRID; 124982; 30.
DR IntAct; Q8N554; 14.
DR MINT; Q8N554; -.
DR STRING; 9606.ENSP00000415836; -.
DR iPTMnet; Q8N554; -.
DR PhosphoSitePlus; Q8N554; -.
DR BioMuta; ZNF276; -.
DR DMDM; 296453082; -.
DR EPD; Q8N554; -.
DR jPOST; Q8N554; -.
DR MassIVE; Q8N554; -.
DR MaxQB; Q8N554; -.
DR PaxDb; Q8N554; -.
DR PeptideAtlas; Q8N554; -.
DR PRIDE; Q8N554; -.
DR ProteomicsDB; 72002; -. [Q8N554-1]
DR ProteomicsDB; 72003; -. [Q8N554-2]
DR Antibodypedia; 17483; 132 antibodies from 19 providers.
DR DNASU; 92822; -.
DR Ensembl; ENST00000289816.9; ENSP00000289816.5; ENSG00000158805.12. [Q8N554-2]
DR Ensembl; ENST00000443381.7; ENSP00000415836.2; ENSG00000158805.12. [Q8N554-1]
DR GeneID; 92822; -.
DR KEGG; hsa:92822; -.
DR MANE-Select; ENST00000443381.7; ENSP00000415836.2; NM_001113525.2; NP_001106997.1.
DR UCSC; uc002foq.5; human. [Q8N554-1]
DR CTD; 92822; -.
DR DisGeNET; 92822; -.
DR GeneCards; ZNF276; -.
DR HGNC; HGNC:23330; ZNF276.
DR HPA; ENSG00000158805; Low tissue specificity.
DR MalaCards; ZNF276; -.
DR MIM; 608460; gene.
DR neXtProt; NX_Q8N554; -.
DR OpenTargets; ENSG00000158805; -.
DR PharmGKB; PA134935042; -.
DR VEuPathDB; HostDB:ENSG00000158805; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158841; -.
DR HOGENOM; CLU_040755_0_0_1; -.
DR InParanoid; Q8N554; -.
DR OMA; LAVKWAW; -.
DR PhylomeDB; Q8N554; -.
DR TreeFam; TF332664; -.
DR PathwayCommons; Q8N554; -.
DR SignaLink; Q8N554; -.
DR BioGRID-ORCS; 92822; 17 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF276; human.
DR GenomeRNAi; 92822; -.
DR Pharos; Q8N554; Tdark.
DR PRO; PR:Q8N554; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N554; protein.
DR Bgee; ENSG00000158805; Expressed in granulocyte and 152 other tissues.
DR ExpressionAtlas; Q8N554; baseline and differential.
DR Genevisible; Q8N554; HS.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF07776; zf-AD; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS51915; ZAD; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Centromere; Chromosome; DNA-binding; Kinetochore;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..614
FT /note="Zinc finger protein 276"
FT /id="PRO_0000047323"
FT DOMAIN 77..163
FT /note="ZAD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT ZN_FING 434..458
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..490
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 496..518
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 524..546
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..577
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT BINDING 82
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT BINDING 136
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT BINDING 139
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT VAR_SEQ 1..75
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14605947,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_026104"
FT VARIANT 263
FT /note="W -> R (in dbSNP:rs6500437)"
FT /evidence="ECO:0000269|PubMed:14605947,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_032708"
FT VARIANT 275
FT /note="R -> W (may increase breast cancer risk)"
FT /evidence="ECO:0000269|PubMed:14605947"
FT /id="VAR_019125"
FT VARIANT 351
FT /note="R -> W (in dbSNP:rs17719249)"
FT /evidence="ECO:0000269|PubMed:14605947"
FT /id="VAR_032709"
FT VARIANT 605
FT /note="E -> D (in dbSNP:rs17227424)"
FT /evidence="ECO:0000269|PubMed:14605947"
FT /id="VAR_019126"
FT CONFLICT 104
FT /note="E -> V (in Ref. 2; AK026482)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="E -> G (in Ref. 2; AK026482)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="P -> Q (in Ref. 3; AAQ15128/AAQ15129)"
FT /evidence="ECO:0000305"
FT CONFLICT 434
FT /note="Y -> H (in Ref. 1; AAI07604)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 614 AA; 67219 MW; D63256CFD7DC5040 CRC64;
MKRDRLGRFL SPGSSRQCGA SDGGGGVSRT RGRPSLSGGP RVDGATARRA WGPVGSCGDA
GEDGADEAGA GRALAMGHCR LCHGKFSSRS LRSISERAPG ASMERPSAEE RVLVRDFQRL
LGVAVRQDPT LSPFVCKSCH AQFYQCHSLL KSFLQRVNAS PAGRRKPCAK VGAQPPTGAE
EGACLVDLIT SSPQCLHGLV GWVHGHAASC GALPHLQRTL SSEYCGVIQV VWGCDQGHDY
TMDTSSSCKA FLLDSALAVK WPWDKETAPR LPQHRGWNPG DAPQTSQGRG TGTPVGAETK
TLPSTDVAQP PSDSDAVGPR SGFPPQPSLP LCRAPGQLGE KQLPSSTSDD RVKDEFSDLS
EGDVLSEDEN DKKQNAQSSD ESFEPYPERK VSGKKSESKE AKKSEEPRIR KKPGPKPGWK
KKLRCEREEL PTIYKCPYQG CTAVYRGADG MKKHIKEHHE EVRERPCPHP GCNKVFMIDR
YLQRHVKLIH TEVRNYICDE CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK
YHMTKHKAET ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QTQDKALPLE AEPPPGPPSP
SVTTEGQAVK PEPT
