ZN276_MOUSE
ID ZN276_MOUSE Reviewed; 614 AA.
AC Q8CE64; Q3TQL7; Q3V088; Q80ZN3; Q8C912; Q9ESV2;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Zinc finger protein 276;
DE Short=Zfp-276;
GN Name=Znf276; Synonyms=Zfp276;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpora quadrigemina, Skin, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 149-614 (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J;
RX PubMed=10936049; DOI=10.1006/geno.2000.6252;
RA Wong J.C., Alon N., Norga K., Kruyt F.A.E., Youssoufian H., Buchwald M.;
RT "Cloning and analysis of the mouse Fanconi anemia group A cDNA and an
RT overlapping penta zinc finger cDNA.";
RL Genomics 67:273-283(2000).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, centromere,
CC kinetochore {ECO:0000250|UniProtKB:Q8N554}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CE64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CE64-2; Sequence=VSP_026106, VSP_026107;
CC -!- TISSUE SPECIFICITY: Found in all the examined tissues, with highest
CC levels in kidney, liver, lung, and spleen.
CC {ECO:0000269|PubMed:10936049}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels in all stages of embryonic
CC development examined. {ECO:0000269|PubMed:10936049}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG01634.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC31505.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK028939; BAC26204.1; -; mRNA.
DR EMBL; AK043258; BAC31505.1; ALT_INIT; mRNA.
DR EMBL; AK133363; BAE21616.1; -; mRNA.
DR EMBL; AK163486; BAE37365.1; -; mRNA.
DR EMBL; AF178935; AAG01634.1; ALT_INIT; mRNA.
DR CCDS; CCDS52699.1; -. [Q8CE64-1]
DR RefSeq; NP_065243.2; NM_020497.2. [Q8CE64-1]
DR AlphaFoldDB; Q8CE64; -.
DR SMR; Q8CE64; -.
DR BioGRID; 208217; 17.
DR IntAct; Q8CE64; 1.
DR STRING; 10090.ENSMUSP00000001092; -.
DR iPTMnet; Q8CE64; -.
DR PhosphoSitePlus; Q8CE64; -.
DR EPD; Q8CE64; -.
DR MaxQB; Q8CE64; -.
DR PaxDb; Q8CE64; -.
DR PeptideAtlas; Q8CE64; -.
DR PRIDE; Q8CE64; -.
DR ProteomicsDB; 275069; -. [Q8CE64-1]
DR ProteomicsDB; 275070; -. [Q8CE64-2]
DR Antibodypedia; 17483; 132 antibodies from 19 providers.
DR DNASU; 57247; -.
DR Ensembl; ENSMUST00000001092; ENSMUSP00000001092; ENSMUSG00000001065. [Q8CE64-1]
DR GeneID; 57247; -.
DR KEGG; mmu:57247; -.
DR UCSC; uc009nva.2; mouse. [Q8CE64-2]
DR UCSC; uc009nvb.2; mouse. [Q8CE64-1]
DR CTD; 57247; -.
DR MGI; MGI:1888495; Zfp276.
DR VEuPathDB; HostDB:ENSMUSG00000001065; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000158841; -.
DR HOGENOM; CLU_040755_0_0_1; -.
DR InParanoid; Q8CE64; -.
DR OMA; LAVKWAW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8CE64; -.
DR TreeFam; TF332664; -.
DR BioGRID-ORCS; 57247; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8CE64; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8CE64; protein.
DR Bgee; ENSMUSG00000001065; Expressed in granulocyte and 197 other tissues.
DR ExpressionAtlas; Q8CE64; baseline and differential.
DR Genevisible; Q8CE64; MM.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043035; F:chromatin insulator sequence binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF07776; zf-AD; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS51915; ZAD; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Centromere; Chromosome; DNA-binding; Kinetochore;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..614
FT /note="Zinc finger protein 276"
FT /id="PRO_0000047324"
FT DOMAIN 78..164
FT /note="ZAD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT ZN_FING 434..458
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..490
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 496..518
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 524..546
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..577
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 80
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT BINDING 83
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT BINDING 140
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01263"
FT VAR_SEQ 337..350
FT /note="QLGETQVPSSTSDD -> KQHLWLMLEQDSVF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026106"
FT VAR_SEQ 351..614
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026107"
FT CONFLICT 353
FT /note="K -> R (in Ref. 1; BAC26204)"
FT /evidence="ECO:0000305"
FT CONFLICT 509..510
FT /note="KH -> ND (in Ref. 2; AAG01634)"
FT /evidence="ECO:0000305"
FT CONFLICT 521
FT /note="A -> G (in Ref. 2; AAG01634)"
FT /evidence="ECO:0000305"
FT CONFLICT 579
FT /note="L -> W (in Ref. 2; AAG01634)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 614 AA; 67339 MW; 1F5716CFADE16533 CRC64;
MKRDRLGRFL SPGIARQRGG SGGGCGSGRT RGRPSRSGGT SADGAAAQLS WGSMTRSCGD
TGDDGTDEAG AGRTLAMGHC RLCHGKFSSR SLRSISDRVP GETSERLSPG ERVFIRDFQR
LLGVAVHQDP ALPQSVCKNC YTQFYQCHSL LRTFLQRVNV SPAGQRKPCT KVGVQPTTVA
EEGACVADLI ASSPRCLHGL VGWVHEHAVS CGSLPSLQRT LSSEYCGIIQ AVWGCDQGHD
FTMDTASSCR ALFLDSALAV KWAWGKDLSP RLAQNSESNP TGAASRLCQA RETQVGSETK
TLPSVDVALL HSHGDSVGPG LGPCTQPHLA PSEAPGQLGE TQVPSSTSDD RVKDEFSDLS
EGDFLSEDES DKKQTPQSSD ESFEPYPEKK VSGKKSEGRE AKRPEEPKIR KKPGPKPGWK
KKLRCEREEL PTIYKCPYQG CTAVYRGADG MKKHIKEHHE EVRERPCPHP GCNKVFMIDR
YLQRHVKLIH TEVRNYICDE CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK
YHMTKHKAET ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QAQDRALPLE AEPPPGPLSP
SGTMEGQAVK PEPT
