ZN283_MACFA
ID ZN283_MACFA Reviewed; 654 AA.
AC Q95K52;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Zinc finger protein 283;
GN Name=ZNF283; ORFNames=QmoA-12446;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Medulla oblongata;
RX PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Prediction of unidentified human genes on the basis of sequence similarity
RT to novel cDNAs from cynomolgus monkey brain.";
RL Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AB066540; BAB62215.1; -; mRNA.
DR RefSeq; NP_001306570.1; NM_001319641.1.
DR AlphaFoldDB; Q95K52; -.
DR SMR; Q95K52; -.
DR STRING; 9541.XP_005589531.1; -.
DR GeneID; 102144887; -.
DR CTD; 284349; -.
DR eggNOG; KOG1721; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..654
FT /note="Zinc finger protein 283"
FT /id="PRO_0000047508"
FT DOMAIN 49..122
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 183..205
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 211..233
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 239..261
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 267..289
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 295..317
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 323..345
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 351..373
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 379..401
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 407..429
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 435..457
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 463..485
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 491..513
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 519..541
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 547..569
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 575..597
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 256
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7M2"
FT CROSSLNK 452
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7M2"
FT CROSSLNK 564
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N7M2"
SQ SEQUENCE 654 AA; 75323 MW; 764E4F940BFB948B CRC64;
MGSLRHAWFN TSFSFPSSGF SGFCASPIEE SHGALISSCN SRTMTDGLVT FRDVAIDFSQ
EEWECLDPAQ RDLYVDVMLE NYSNLVSLDL ESTTYETKKI FSEKDIFEIN FSQWEMKEKS
KTLGLEASIF RNNWKCKSIF KGLKGCQEGY FSQMIISYEE IPSYRKSKSL TPHQSIHNTE
KPYVYKERVN ACSHGSKLVQ HKRTHTAEKH FECKECGKNY LSAYQLNVHQ RFHTGEKPYE
CKECGKTFSW GSSLVKHERI HTGEKPYECK ECGKAFSRGY HLTQHQKIHI GVKSYKCKEC
GKAFFWGSSL AKHEIIHTGE KPYQCKECGK AFSRGYQLTQ HQKIHTGKKP YECKICGKAF
CWGYQLTRHQ IFHTGEKPYE CKECGKAFNC GSSLIQHARI HTGEKPYECK ECGKAFSRGY
HLSQHQKIHT GEKPFECKEC GKAFSWGSSL VKHERVHTGE KSHECKECGK NFCSGYQLTR
HQVFHTGEKP YECKECGKAF NCGSSLVQHE RIHTGEKPYE CKECGKAFSR GYHLTQHQKI
HTGEKPFKCK ECGKAFSWGS SLIKHERVHT NEKTYGCKDC GKAFGSGYQL SVHQRFHTGE
KLYQCKEFGK TFTHGSKLVH ERTCNDKPYK YKECGEAFLW TTYSNEKIDT DETL
