ZN284_HUMAN
ID ZN284_HUMAN Reviewed; 593 AA.
AC Q2VY69; Q86WM1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Zinc finger protein 284;
GN Name=ZNF284; Synonyms=ZNF284L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=16817023; DOI=10.1007/s11033-005-6405-3;
RA Yin G., Ji C., Zeng L., Wang Z., Wang J., Shen Z., Wu T., Gu S., Xie Y.,
RA Mao Y.;
RT "Cloning and characterization of a novel KRAB-domain-containing zinc finger
RT gene (ZNF284L).";
RL Mol. Biol. Rep. 33:137-144(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 29-232, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=12743021; DOI=10.1101/gr.963903;
RA Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.;
RT "Differential expansion of zinc-finger transcription factor loci in
RT homologous human and mouse gene clusters.";
RL Genome Res. 13:1097-1110(2003).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in lung, liver, pancreas and thymus.
CC Lower expression in heart, placenta, spleen, prostate, ovary, small
CC intestine and colon. No expression seen in brain, skeletal muscle,
CC kidney, testis and peripheral blood leukocyte.
CC {ECO:0000269|PubMed:12743021, ECO:0000269|PubMed:16817023}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AY458845; AAS13443.1; -; mRNA.
DR EMBL; AY166789; AAO45838.1; -; mRNA.
DR CCDS; CCDS46099.1; -.
DR RefSeq; NP_001032902.1; NM_001037813.3.
DR RefSeq; XP_011525209.1; XM_011526907.2.
DR RefSeq; XP_011525210.1; XM_011526908.2.
DR AlphaFoldDB; Q2VY69; -.
DR SMR; Q2VY69; -.
DR BioGRID; 131208; 17.
DR IntAct; Q2VY69; 3.
DR STRING; 9606.ENSP00000411032; -.
DR iPTMnet; Q2VY69; -.
DR PhosphoSitePlus; Q2VY69; -.
DR BioMuta; ZNF284; -.
DR DMDM; 121941972; -.
DR jPOST; Q2VY69; -.
DR MassIVE; Q2VY69; -.
DR PaxDb; Q2VY69; -.
DR PeptideAtlas; Q2VY69; -.
DR PRIDE; Q2VY69; -.
DR ProteomicsDB; 61527; -.
DR Antibodypedia; 31158; 76 antibodies from 17 providers.
DR DNASU; 342909; -.
DR Ensembl; ENST00000421176.4; ENSP00000411032.2; ENSG00000186026.7.
DR GeneID; 342909; -.
DR KEGG; hsa:342909; -.
DR MANE-Select; ENST00000421176.4; ENSP00000411032.2; NM_001037813.4; NP_001032902.1.
DR UCSC; uc002oyg.2; human.
DR CTD; 342909; -.
DR GeneCards; ZNF284; -.
DR HGNC; HGNC:13078; ZNF284.
DR HPA; ENSG00000186026; Low tissue specificity.
DR neXtProt; NX_Q2VY69; -.
DR OpenTargets; ENSG00000186026; -.
DR PharmGKB; PA37654; -.
DR VEuPathDB; HostDB:ENSG00000186026; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160225; -.
DR HOGENOM; CLU_002678_31_5_1; -.
DR InParanoid; Q2VY69; -.
DR OMA; ISHTCNE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q2VY69; -.
DR TreeFam; TF341885; -.
DR PathwayCommons; Q2VY69; -.
DR SignaLink; Q2VY69; -.
DR BioGRID-ORCS; 342909; 167 hits in 1093 CRISPR screens.
DR ChiTaRS; ZNF284; human.
DR GenomeRNAi; 342909; -.
DR Pharos; Q2VY69; Tdark.
DR PRO; PR:Q2VY69; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q2VY69; protein.
DR Bgee; ENSG00000186026; Expressed in oviduct epithelium and 156 other tissues.
DR Genevisible; Q2VY69; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..593
FT /note="Zinc finger protein 284"
FT /id="PRO_0000280403"
FT DOMAIN 8..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..169
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 175..197
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 371..393
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 399..421
FT /note="C2H2-type 10; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 539..561
FT /note="C2H2-type 15; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 546
FT /note="K -> E (in dbSNP:rs8113249)"
FT /id="VAR_031135"
FT VARIANT 577
FT /note="E -> K (in dbSNP:rs8113249)"
FT /id="VAR_059909"
SQ SEQUENCE 593 AA; 69019 MW; AA147748E360DA84 CRC64;
MTMFKEAVTF KDVAVVFTEE ELGLLDVSQR KLYRDVMLEN FRNLLSVGHQ LSHRDTFHFQ
REEKFWIMET ATQREGNSGG KIQTELESVP ETGPHEEWSC QQIWEQTASE LTRPQDSISS
SQFSTQGDVP SQVDAGLSII HIGETPSEHG KCKKFFSDVS ILDLHQQLHS GKISHTCNEY
RKRFCYSSAL CLHQKVHMGE KRYKCDVCSK AFSQNSQLQT HQRIHTGEKP FKCEQCGKSF
SRRSGMYVHC KLHTGEKPHI CEECGKAFIH NSQLREHQRI HTGEKPFKCY ICGKSFHSRS
NLNRHSMVHM QEKSFRCDTC SNSFGQRSAL NSHCMDHTKE KLYKCEECGR SFTCRQDLCK
HQMDHTGDKP YNCNVCGKGF RWSSCLSRHQ RVHNGETTFK CDGCGKRFYM NSQGHSHQRA
YREEELYKCQ KCGKGYISKF NLDLHQRVHT GERPYNCKEC GKSFRWASGI LRHKRLHTGE
KPFKCEECGK RFTENSKLRF HQRIHTGEKP YKCEECGKGF RWASTHLTHQ RLHSREKLFQ
CEDCGKSSEH SSCLQDQQSD HSGEKTSKCE DCGKRYERRL NLDMILSLFL NDI
