ZN285_HUMAN
ID ZN285_HUMAN Reviewed; 590 AA.
AC Q96NJ3; Q17RJ3; Q6B0A8; Q6ISR5;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 285;
DE AltName: Full=Zinc finger protein 285A;
GN Name=ZNF285; Synonyms=ZNF285A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96NJ3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-18064466, EBI-3866279;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96NJ3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NJ3-2; Sequence=VSP_037502;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK055309; BAB70901.1; -; mRNA.
DR EMBL; AC138473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117300; AAI17301.1; -; mRNA.
DR EMBL; BC117302; AAI17303.1; -; mRNA.
DR EMBL; BC069384; AAH69384.2; -; mRNA.
DR EMBL; BC074875; AAH74875.2; -; mRNA.
DR CCDS; CCDS12638.1; -. [Q96NJ3-1]
DR RefSeq; NP_001278417.1; NM_001291488.1.
DR RefSeq; NP_001278418.1; NM_001291489.1.
DR RefSeq; NP_001278419.1; NM_001291490.1.
DR RefSeq; NP_001278420.1; NM_001291491.1.
DR RefSeq; NP_689567.4; NM_152354.5.
DR AlphaFoldDB; Q96NJ3; -.
DR BioGRID; 117930; 1.
DR IntAct; Q96NJ3; 3.
DR STRING; 9606.ENSP00000464788; -.
DR iPTMnet; Q96NJ3; -.
DR PhosphoSitePlus; Q96NJ3; -.
DR BioMuta; ZNF285; -.
DR DMDM; 239938813; -.
DR jPOST; Q96NJ3; -.
DR MassIVE; Q96NJ3; -.
DR PaxDb; Q96NJ3; -.
DR PeptideAtlas; Q96NJ3; -.
DR PRIDE; Q96NJ3; -.
DR ProteomicsDB; 77520; -. [Q96NJ3-1]
DR ProteomicsDB; 77521; -. [Q96NJ3-2]
DR Antibodypedia; 65032; 66 antibodies from 12 providers.
DR DNASU; 26974; -.
DR Ensembl; ENST00000544719.6; ENSP00000439431.2; ENSG00000267508.6. [Q96NJ3-1]
DR Ensembl; ENST00000614994.5; ENSP00000483662.1; ENSG00000267508.6. [Q96NJ3-1]
DR GeneID; 26974; -.
DR KEGG; hsa:26974; -.
DR MANE-Select; ENST00000614994.5; ENSP00000483662.1; NM_152354.6; NP_689567.4.
DR UCSC; uc002ozd.5; human. [Q96NJ3-1]
DR CTD; 26974; -.
DR DisGeNET; 26974; -.
DR GeneCards; ZNF285; -.
DR HGNC; HGNC:13079; ZNF285.
DR HPA; ENSG00000267508; Low tissue specificity.
DR neXtProt; NX_Q96NJ3; -.
DR OpenTargets; ENSG00000267508; -.
DR PharmGKB; PA165394833; -.
DR VEuPathDB; HostDB:ENSG00000267508; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163580; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q96NJ3; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96NJ3; -.
DR TreeFam; TF350845; -.
DR PathwayCommons; Q96NJ3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96NJ3; -.
DR BioGRID-ORCS; 26974; 122 hits in 1047 CRISPR screens.
DR GenomeRNAi; 26974; -.
DR Pharos; Q96NJ3; Tdark.
DR PRO; PR:Q96NJ3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96NJ3; protein.
DR Bgee; ENSG00000267508; Expressed in secondary oocyte and 134 other tissues.
DR ExpressionAtlas; Q96NJ3; baseline and differential.
DR Genevisible; Q96NJ3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..590
FT /note="Zinc finger protein 285"
FT /id="PRO_0000378106"
FT DOMAIN 8..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 232..254
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..450
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 456..478
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 484..506
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 512..534
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 540..562
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..155
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_037502"
FT VARIANT 208
FT /note="S -> N (in dbSNP:rs2571089)"
FT /id="VAR_057972"
FT VARIANT 536
FT /note="G -> R (in dbSNP:rs12610859)"
FT /id="VAR_057973"
SQ SEQUENCE 590 AA; 68135 MW; 2CF340F4DDCA4DD1 CRC64;
MIKFQERVTF KDVAVVFTKE ELALLDKAQI NLYQDVMLEN FRNLMLVRDG IKNNILNLQA
KGLSYLSQEV LHCWQIWKQR IRDLTVSQDY IVNLQEECSP HLEDVSLSEE WAGISLQISE
NENYVVNAII KNQDITAWQS LTQVLTPESW RKANIMTEPQ NSQGRYKGIY MEEKLYRRAQ
HDDSLSWTSC DHHESQECKG EDPGRHPSCG KNLGMKSTVE KRNAAHVLPQ PFPCNNCGVA
FADDTDPHVH HSTHLGEKSY KCDQYGKNFS QSQDLIVHCK THSGKTPYEF HEWPMGCKQS
SDLPRYQKVS SGDKPYKCKE CGKGFRRSSS LHNHHRVHTG EMPYKCDECG KGFGFRSLLC
IHQGVHTGKK PYKCEECGKG FDQSSNLLVH QRVHTGEKPY KCSECGKCFS SSSVLQVHWR
FHTGEKPYRC GECGKGFSQC THLHIHQRVH TGEKPYKCNV CGKDFAYSSV LHTHQRVHTG
EKPYKCEVCG KCFSYSSYFH LHQRDHIREK PYKCDECGKG FSRNSDLNVH LRVHTGERPY
KCKACGKGFS RNSYLLAHQR VHIDETQYTH CERGKDLLTH QRLHEQRETL
