ZN287_HUMAN
ID ZN287_HUMAN Reviewed; 761 AA.
AC Q9HBT7; Q6IAG1;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-DEC-2019, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Zinc finger protein 287 {ECO:0000305};
DE AltName: Full=Zinc finger protein with KRAB and SCAN domains 13;
GN Name=ZNF287 {ECO:0000312|HGNC:HGNC:13502}; Synonyms=ZKSCAN13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Romero-Pastrana F., Srivastava A.K.;
RT "Deletion of a novel zinc finger gene in Smith-Magenis syndrome.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-761.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG09702.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI01488.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI13364.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF217227; AAG09702.1; ALT_INIT; mRNA.
DR EMBL; AC127540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101487; AAI01488.1; ALT_INIT; mRNA.
DR EMBL; BC113363; AAI13364.1; ALT_INIT; mRNA.
DR EMBL; CR457194; CAG33475.1; -; mRNA.
DR CCDS; CCDS11179.2; -.
DR RefSeq; NP_001333096.1; NM_001346167.1.
DR RefSeq; NP_001333097.1; NM_001346168.1.
DR RefSeq; NP_001333098.1; NM_001346169.1.
DR RefSeq; NP_065704.2; NM_020653.3.
DR RefSeq; XP_011522270.1; XM_011523968.2.
DR AlphaFoldDB; Q9HBT7; -.
DR SMR; Q9HBT7; -.
DR BioGRID; 121490; 12.
DR IntAct; Q9HBT7; 1.
DR STRING; 9606.ENSP00000379168; -.
DR iPTMnet; Q9HBT7; -.
DR PhosphoSitePlus; Q9HBT7; -.
DR BioMuta; ZNF287; -.
DR DMDM; 20141038; -.
DR jPOST; Q9HBT7; -.
DR MassIVE; Q9HBT7; -.
DR MaxQB; Q9HBT7; -.
DR PaxDb; Q9HBT7; -.
DR PeptideAtlas; Q9HBT7; -.
DR PRIDE; Q9HBT7; -.
DR ProteomicsDB; 81591; -.
DR Antibodypedia; 25338; 205 antibodies from 29 providers.
DR DNASU; 57336; -.
DR Ensembl; ENST00000395824.5; ENSP00000379168.1; ENSG00000141040.15.
DR Ensembl; ENST00000395825.4; ENSP00000379169.3; ENSG00000141040.15.
DR GeneID; 57336; -.
DR KEGG; hsa:57336; -.
DR MANE-Select; ENST00000395825.4; ENSP00000379169.3; NM_020653.4; NP_065704.2.
DR UCSC; uc002gqi.3; human.
DR CTD; 57336; -.
DR DisGeNET; 57336; -.
DR GeneCards; ZNF287; -.
DR HGNC; HGNC:13502; ZNF287.
DR HPA; ENSG00000141040; Low tissue specificity.
DR neXtProt; NX_Q9HBT7; -.
DR OpenTargets; ENSG00000141040; -.
DR PharmGKB; PA37788; -.
DR VEuPathDB; HostDB:ENSG00000141040; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162333; -.
DR HOGENOM; CLU_002678_49_8_1; -.
DR InParanoid; Q9HBT7; -.
DR OMA; CTPVTNT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9HBT7; -.
DR TreeFam; TF350843; -.
DR PathwayCommons; Q9HBT7; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9HBT7; -.
DR Pharos; Q9HBT7; Tdark.
DR PRO; PR:Q9HBT7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9HBT7; protein.
DR Bgee; ENSG00000141040; Expressed in left adrenal gland cortex and 111 other tissues.
DR ExpressionAtlas; Q9HBT7; baseline and differential.
DR Genevisible; Q9HBT7; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0001817; P:regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..761
FT /note="Zinc finger protein 287"
FT /id="PRO_0000047511"
FT DOMAIN 49..131
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 170..238
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 368..390
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..530
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 592..614
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 620..642
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 648..670
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 676..698
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 704..726
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 732..754
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 134..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 281
FT /note="K -> T (in dbSNP:rs7224723)"
FT /id="VAR_024207"
SQ SEQUENCE 761 AA; 88339 MW; C8FF17233AEEC04E CRC64;
MLASSKRMNS SSRSQILLRW KSDKAQSGPY NVEKEILTSR FLRDTETCRQ NFRNFPYPDL
AGPRKALSQL RELCLKWLRP EIHSKEQILE LLVLEQFLTI LPGEVRTWVK SQYPESSEEA
VTLVEDLTQI LEEEAPQNST LSQDTPEEDP RGKHAFQTGW LNDLVTKESM TFKDVAVDIT
QEDWELMRPV QKELYKTVTL QNYWNMVSLG LTVYRPTVIP ILEEPWMVIK EILEGPSPEW
ETKAQACTPV EDMSKLTKEE THTIKLEDSY DYDDRLERRG KGGFWKIHTD ERGFSLKSVL
SQEYDPTEEC LSKYDIYRNN FEKHSNLIVQ FDTQLDNKTS VYNEGRATFN HVSYGIVHRK
ILPGEKPYKC NVCGKKFRKY PSLLKHQSTH AKEKSYECEE CGKEFRHISS LIAHQRMHTG
EKPYECHQCG KAFSQRAHLT IHQRIHTGEK PYKCDDCGKD FSQRAHLTIH QRTHTGEKPY
KCLECGKTFS HSSSLINHQR VHTGEKPYIC NECGKTFSQS THLLQHQKIH TGKKPYKCNE
CWKVFSQSTY LIRHQRIHSG EKCYKCNECG KAFAHSSTLI QHQTTHTGEK SYICNICGKA
FSQSANLTQH HRTHTGEKPY KCSVCGKAFS QSVHLTQHQR IHNGEKPFKC NICGKAYRQG
ANLTQHQRIH TGEKPYKCNE CGKAFIYSSS LNQHQRTHTG ERPYKCNECD KDFSQRTCLI
QHQRIHTGEK PYACRICGKT FTQSTNLIQH QRVHTGAKHR N
