ZN287_MOUSE
ID ZN287_MOUSE Reviewed; 759 AA.
AC Q9EQB9; Q8CDU3;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 287 {ECO:0000305};
DE Short=Zfp-287;
DE AltName: Full=Zinc finger protein SKAT-2;
GN Name=Znf287 {ECO:0000312|MGI:MGI:2176561}; Synonyms=Skat2, Zfp287;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=D0.11.10;
RX PubMed=11093124;
RX DOI=10.1002/1521-4141(200011)30:11<3100::aid-immu3100>3.0.co;2-w;
RA Blanchard A.D., Page K.R., Watkin H., Hayward P., Wong T., Bartholomew M.,
RA Quint D.J., Daly M., Garcia-Lopez J., Champion B.R.;
RT "Identification and characterization of SKAT-2, a novel Th2-specific zinc
RT finger gene.";
RL Eur. J. Immunol. 30:3100-3110(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain and at low levels in kidney and
CC spleen and few hematopoietic cell lines.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF281141; AAG37028.1; -; mRNA.
DR EMBL; AK029572; BAC26519.1; -; mRNA.
DR EMBL; BC117876; AAI17877.1; -; mRNA.
DR CCDS; CCDS24830.1; -.
DR RefSeq; NP_573471.2; NM_133208.2.
DR RefSeq; XP_006532443.1; XM_006532380.2.
DR AlphaFoldDB; Q9EQB9; -.
DR SMR; Q9EQB9; -.
DR BioGRID; 228406; 52.
DR STRING; 10090.ENSMUSP00000141046; -.
DR iPTMnet; Q9EQB9; -.
DR PhosphoSitePlus; Q9EQB9; -.
DR PaxDb; Q9EQB9; -.
DR PRIDE; Q9EQB9; -.
DR Antibodypedia; 25338; 205 antibodies from 29 providers.
DR DNASU; 170740; -.
DR Ensembl; ENSMUST00000149228; ENSMUSP00000114531; ENSMUSG00000005267.
DR Ensembl; ENSMUST00000185656; ENSMUSP00000141046; ENSMUSG00000005267.
DR GeneID; 170740; -.
DR KEGG; mmu:170740; -.
DR UCSC; uc007jju.1; mouse.
DR CTD; 170740; -.
DR MGI; MGI:2176561; Zfp287.
DR VEuPathDB; HostDB:ENSMUSG00000005267; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162333; -.
DR InParanoid; Q9EQB9; -.
DR OMA; CTPVTNT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9EQB9; -.
DR BioGRID-ORCS; 170740; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp287; mouse.
DR PRO; PR:Q9EQB9; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9EQB9; protein.
DR Bgee; ENSMUSG00000005267; Expressed in rostral migratory stream and 196 other tissues.
DR ExpressionAtlas; Q9EQB9; baseline and differential.
DR Genevisible; Q9EQB9; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0001817; P:regulation of cytokine production; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..759
FT /note="Zinc finger protein 287"
FT /id="PRO_0000047512"
FT DOMAIN 42..124
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 166..234
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 366..388
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 562..584
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 590..612
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 618..640
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 646..668
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 674..696
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 702..724
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 730..752
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 127..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 28
FT /note="Q -> R (in Ref. 1; AAG37028)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="E -> G (in Ref. 1; AAG37028)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="Y -> H (in Ref. 1; AAG37028)"
FT /evidence="ECO:0000305"
FT CONFLICT 672
FT /note="K -> R (in Ref. 1; AAG37028)"
FT /evidence="ECO:0000305"
FT CONFLICT 736
FT /note="G -> E (in Ref. 1; AAG37028)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 759 AA; 86635 MW; 36A0B0E1AB258368 CRC64;
MANSSLSQVL LMWKPGKIQK GPCSAEQQTL TSRLLRDTET CRRNFRNFPY PDVAGPRKAL
CQLRELCLKW LRPEVHSKEQ ILELLVLEQF LSILPGEVRT WVNSQYPESS EEVVALVEDL
TQILEEEEAP QSSALPQDTP EDDPNHDPNP ASQAGWLSDV VTKDLVTFND VAVDITQEDW
ELMPPVQKEL YKTVTLQNYW NMVSLGLTVY RPTVIPVLEE PWMVIKEIVE GPNPEWEPKA
QAQCPAKHLP ELKQDGTQTV KLEDSYDDDN DDSVESPPVC AFGMIHIDEE GFSVKSELSQ
EDPTEEYLSK CDIYRVTFEK HTNLGVQFDT QSDDKTALYN ESKPPFSNAS SGGAVRGKIL
PGDKPYSCNV CGKQFRKYPS LLAHRENHAK EKAYECEECG KEFKHLSSLI AHQRMHTGEK
PYECHQCGKA FSQRAHLTIH QRIHTGEKPY KCEDCGKDFS QRAHLTIHQR THTGEKPYKC
LECSKTFSHS SSLINHQRVH TGEKPYICNE CGKTFSQSTH LLQHQKIHTG KKPYKCNECW
KVFSQSTYLI RHQRIHSGEK CYKCTACGKA FAHSSTLIQH QTTHTGEKSY ICNVCGKAFS
QSANLTQHHR THTGEKPYKC SVCGKAFSQS VHLTQHQRIH NGEKPFKCNT CGKAYRQGAN
LTQHQRVHTG EKPYKCHHCG KAFIYSSSLN QHRRTHTGER PYKCSHCNKD FSQRTCLIQH
QRIHTGEKPY GCRICGKAFT QSTNLIQHQR VHTGARHRN
