ID   ZN287_PONPY             Reviewed;         761 AA.
AC   A2T812;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2019, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Zinc finger protein 287 {ECO:0000250|UniProtKB:Q9HBT7};
GN   Name=ZNF287 {ECO:0000250|UniProtKB:Q9HBT7};
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABM89440.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DQ977580; ABM89440.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A2T812; -.
DR   SMR; A2T812; -.
DR   PRIDE; A2T812; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 1.10.4020.10; -; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 14.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 8.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..761
FT                   /note="Zinc finger protein 287"
FT                   /id="PRO_0000285472"
FT   DOMAIN          49..131
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   DOMAIN          170..238
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         368..390
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         396..418
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         424..446
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         452..474
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         480..502
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         508..530
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         536..558
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         564..586
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         592..614
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         620..642
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         648..670
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         676..698
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         704..726
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         732..754
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          134..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   761 AA;  88288 MW;  B9F5CF3958A1C622 CRC64;
     MLASSKRMNS SSRSQILLRW KSDKAQSGPY NVEKEILTSR FLRDTETCRQ NFRNFPYPDL
     AGPRKALSQL RELCLKWLRP EIHSKEQILE LLVLEQFLTI LPGEVRTWVK SQYPESSEEA
     VTLVEDLTQI LEEEAPQNST LSQDTPEEDP RGKHAFQTGW LNDLVTKESM TFKDVAVDIT
     QEDWELMRPV QKELYKTVTL QNYWNMVSLG LTVYRPTVIP ILEEPWMVIK EILEGPSPEW
     ETKAQACTPV EDMSKLTKEE TQTIKLEDSY DYDDRLERRA TGGFWKIHTN ERGFSLKSAL
     SQEYDPTEEC LSKYDIYRNN FEKHSNLIVQ FDTQLDNKTS VYNEGRATFN HVSYGIVHRK
     ILPGEKPYKC NVCGKKFRKY PSLLKHQSTH AKEKSYECEE CGKEFRHISS LIAHQRMHTG
     EKPYECHQCG KAFSQRAHLT IHQRIHTGEK PYKCDDCGKD FSQRAHLTIH QRTHTGEKPY
     KCLECGKTFS HSSSLINHQR VHTGEKPYIC NECGKTFSQS THLLQHQKIH TGKKPYKCNE
     CWKVFSQSTY LIRHQRIHSG EKCYKCNECG KAFAHSSTLI QHQTTHTGEK SYICNICGKA
     FSQSANLTQH HRTHTGEKPY KCSVCGKAFS QSVHLTQHQR IHNGEKPFKC NICGKAYRQG
     ANLTQHQRIH TGEKPYKCNE CGKAFIYSSS LNQHQRTHTG ERPYKCNECD KDFSQRTCLI
     QHQRIHTGEK PYACRICGKT FTQSTNLIQH QRVHTGAKHR N