ZN311_HUMAN
ID ZN311_HUMAN Reviewed; 666 AA.
AC Q5JNZ3; A2BFK5; B0S7Y4; Q92971;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Zinc finger protein 311;
DE AltName: Full=Zinc finger protein zfp-31;
GN Name=ZNF311; Synonyms=ZFP31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-511.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 328-547.
RX PubMed=10520746; DOI=10.3109/10425179809072191;
RA Petroni D., Bartolini E., Chiaramonte R., Ottolenghi S., Comi P.;
RT "Computer sequence analysis of human highly conserved zinc finger
RT modules.";
RL DNA Seq. 9:163-169(1998).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB16812.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL662791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX293545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136745; AAI36746.1; -; mRNA.
DR EMBL; U71600; AAB16812.1; ALT_FRAME; mRNA.
DR CCDS; CCDS34357.1; -.
DR RefSeq; NP_001010877.2; NM_001010877.3.
DR RefSeq; NP_001305463.1; NM_001318534.1.
DR RefSeq; XP_016866247.1; XM_017010758.1.
DR RefSeq; XP_016866248.1; XM_017010759.1.
DR AlphaFoldDB; Q5JNZ3; -.
DR SMR; Q5JNZ3; -.
DR BioGRID; 129424; 6.
DR IntAct; Q5JNZ3; 6.
DR STRING; 9606.ENSP00000366384; -.
DR iPTMnet; Q5JNZ3; -.
DR PhosphoSitePlus; Q5JNZ3; -.
DR BioMuta; ZNF311; -.
DR DMDM; 143758539; -.
DR jPOST; Q5JNZ3; -.
DR MassIVE; Q5JNZ3; -.
DR MaxQB; Q5JNZ3; -.
DR PaxDb; Q5JNZ3; -.
DR PeptideAtlas; Q5JNZ3; -.
DR PRIDE; Q5JNZ3; -.
DR ProteomicsDB; 62993; -.
DR Antibodypedia; 54802; 25 antibodies from 13 providers.
DR DNASU; 282890; -.
DR Ensembl; ENST00000377179.4; ENSP00000366384.3; ENSG00000197935.7.
DR Ensembl; ENST00000383655.4; ENSP00000373151.4; ENSG00000169260.11.
DR Ensembl; ENST00000426120.2; ENSP00000398983.2; ENSG00000225351.4.
DR Ensembl; ENST00000429714.2; ENSP00000399157.2; ENSG00000235178.4.
DR Ensembl; ENST00000436574.2; ENSP00000405154.2; ENSG00000235589.4.
DR Ensembl; ENST00000452316.2; ENSP00000415772.2; ENSG00000223687.4.
DR Ensembl; ENST00000458265.2; ENSP00000398440.2; ENSG00000233831.4.
DR GeneID; 282890; -.
DR KEGG; hsa:282890; -.
DR MANE-Select; ENST00000377179.4; ENSP00000366384.3; NM_001382360.1; NP_001369289.1.
DR UCSC; uc003nlu.3; human.
DR CTD; 282890; -.
DR DisGeNET; 282890; -.
DR GeneCards; ZNF311; -.
DR HGNC; HGNC:13847; ZNF311.
DR HPA; ENSG00000197935; Tissue enhanced (testis).
DR neXtProt; NX_Q5JNZ3; -.
DR OpenTargets; ENSG00000197935; -.
DR PharmGKB; PA134865305; -.
DR VEuPathDB; HostDB:ENSG00000197935; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163512; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q5JNZ3; -.
DR OMA; EWQCLTH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5JNZ3; -.
DR TreeFam; TF341635; -.
DR PathwayCommons; Q5JNZ3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q5JNZ3; -.
DR BioGRID-ORCS; 282890; 11 hits in 1098 CRISPR screens.
DR GenomeRNAi; 282890; -.
DR Pharos; Q5JNZ3; Tdark.
DR PRO; PR:Q5JNZ3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5JNZ3; protein.
DR Bgee; ENSG00000197935; Expressed in cortical plate and 95 other tissues.
DR ExpressionAtlas; Q5JNZ3; baseline and differential.
DR Genevisible; Q5JNZ3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..666
FT /note="Zinc finger protein 311"
FT /id="PRO_0000280404"
FT DOMAIN 64..135
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 247..269
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 275..297
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 303..325
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 331..353
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 359..381
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 387..409
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 415..437
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 443..465
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 471..493
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 499..521
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 527..549
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 555..577
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 583..605
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 611..634
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 486
FT /note="R -> C (in dbSNP:rs9295783)"
FT /id="VAR_031136"
FT VARIANT 511
FT /note="K -> Q (in dbSNP:rs6456880)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_031137"
SQ SEQUENCE 666 AA; 76322 MW; 24407CFED3DE28E6 CRC64;
MQEVVLLDES SGPPSQLLWT RQDTQLPQES ALLPAPYPAF TKDGSQGNLP QADITLMSQA
QESVTFEDVA VNFTNREWQC LTYAQRHLYK DVMLENYGNM VSLGFPFPKP PLISHLEREV
DPCVQDPQDR ESLSCSYPVS ADKMWPENEK ASSQQEIFEN GEAYWMKFNS LLKVDSRDPK
VREVCVQDVK LENQWETSIR EKLREEKEGS EEVTCKKGKN QKVLSKNLNP NSKHSQCNKV
LIAQKLHECA RCGKNFSWHS DLILHEQIHS GEKPHVCNEC GKAFKTRNQL SMHRIIHTGE
KPFNCTQCGK AFNSRSALCR HKKTHSGEKP HECRDCGKAF KTRNRLCMHQ LIHTGEKPYK
CNCCGKAFQF KHSLTIHGRI HTGEKPYECE ECGKAFSGSS DLTKHIRIHT GERPYECSKC
GRAFSRSSDL SKHKRIHTRE KHYGCPQCGK DFSIKAELTK HRRIHTEEKR YRCEECGKAF
RHNCKRRAHE REHTGEKPYQ CRDCGKTFQD KHCLTIHQRI HTGEKPYKCL ECGKAFSGKS
NLTNHRRIHT GEKPHKCEVC GMAFHHSSVL RQHKRIHTGE KPYTCSECGT SFRQGSALIG
HKRVHTGEKP YECEECGKAF RVSSNLTGHK KRKHQVWSTH ELDGSRKSLS PVTVSQTSVV
SILTSA
