ZN317_HUMAN
ID ZN317_HUMAN Reviewed; 595 AA.
AC Q96PQ6; Q6DCA9; Q96PM0; Q96PM1; Q96PT2; Q9HCI4;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=Zinc finger protein 317;
GN Name=ZNF317; Synonyms=KIAA1588;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND TISSUE
RP SPECIFICITY.
RX PubMed=11688974; DOI=10.1006/bbrc.2001.5855;
RA Takashima H., Nishio H., Wakao H., Nishio M., Koizumi K., Oda A., Koike T.,
RA Sawada Ki K.;
RT "Molecular cloning and characterization of a KRAB-containing zinc finger
RT protein, ZNF317, and its isoforms.";
RL Biochem. Biophys. Res. Commun. 288:771-779(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May function as a transcription factor. May play an important
CC role in erythroid maturation and lymphoid proliferation.
CC -!- INTERACTION:
CC Q96PQ6; Q8WTP8: AEN; NbExp=4; IntAct=EBI-1210473, EBI-8637627;
CC Q96PQ6; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-1210473, EBI-742750;
CC Q96PQ6; Q96Q77: CIB3; NbExp=5; IntAct=EBI-1210473, EBI-10292696;
CC Q96PQ6; P49760: CLK2; NbExp=3; IntAct=EBI-1210473, EBI-750020;
CC Q96PQ6; Q6ZUT1: NKAPD1; NbExp=7; IntAct=EBI-1210473, EBI-3920396;
CC Q96PQ6; P98175: RBM10; NbExp=3; IntAct=EBI-1210473, EBI-721525;
CC Q96PQ6; P0DJD3: RBMY1A1; NbExp=5; IntAct=EBI-1210473, EBI-8638511;
CC Q96PQ6; P0DJD3-2: RBMY1A1; NbExp=3; IntAct=EBI-1210473, EBI-11994018;
CC Q96PQ6; Q15415: RBMY1J; NbExp=5; IntAct=EBI-1210473, EBI-8642021;
CC Q96PQ6; P10074: ZBTB48; NbExp=3; IntAct=EBI-1210473, EBI-744864;
CC Q96PQ6; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-1210473, EBI-347633;
CC Q96PQ6; Q96C55: ZNF524; NbExp=3; IntAct=EBI-1210473, EBI-10283126;
CC Q96PQ6; Q5T619: ZNF648; NbExp=3; IntAct=EBI-1210473, EBI-11985915;
CC Q96PQ6; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-1210473, EBI-11962574;
CC Q96PQ6-4; Q6A162: KRT40; NbExp=3; IntAct=EBI-10292528, EBI-10171697;
CC Q96PQ6-4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10292528, EBI-10172052;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=2; Synonyms=ZNF317-2;
CC IsoId=Q96PQ6-1; Sequence=Displayed;
CC Name=1; Synonyms=ZNF317-1;
CC IsoId=Q96PQ6-2; Sequence=VSP_006916;
CC Name=3; Synonyms=ZNF317-3;
CC IsoId=Q96PQ6-3; Sequence=VSP_006915, VSP_006916;
CC Name=4; Synonyms=ZNF317-4;
CC IsoId=Q96PQ6-4; Sequence=VSP_006915;
CC -!- TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed.
CC Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and
CC lung. {ECO:0000269|PubMed:11688974}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13414.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF275255; AAL29188.1; -; mRNA.
DR EMBL; AF148135; AAL29182.1; -; mRNA.
DR EMBL; AF307096; AAL29190.1; -; mRNA.
DR EMBL; AF307097; AAL29191.1; -; mRNA.
DR EMBL; AB046808; BAB13414.1; ALT_INIT; mRNA.
DR EMBL; CH471106; EAW84011.1; -; Genomic_DNA.
DR EMBL; BC078154; AAH78154.1; -; mRNA.
DR CCDS; CCDS12210.1; -. [Q96PQ6-1]
DR CCDS; CCDS54213.1; -. [Q96PQ6-2]
DR PIR; JC7779; JC7779.
DR RefSeq; NP_001177720.1; NM_001190791.1. [Q96PQ6-2]
DR RefSeq; NP_065984.3; NM_020933.4. [Q96PQ6-1]
DR AlphaFoldDB; Q96PQ6; -.
DR SMR; Q96PQ6; -.
DR BioGRID; 121719; 64.
DR IntAct; Q96PQ6; 25.
DR MINT; Q96PQ6; -.
DR STRING; 9606.ENSP00000247956; -.
DR iPTMnet; Q96PQ6; -.
DR PhosphoSitePlus; Q96PQ6; -.
DR BioMuta; ZNF317; -.
DR DMDM; 229462794; -.
DR EPD; Q96PQ6; -.
DR jPOST; Q96PQ6; -.
DR MassIVE; Q96PQ6; -.
DR MaxQB; Q96PQ6; -.
DR PaxDb; Q96PQ6; -.
DR PeptideAtlas; Q96PQ6; -.
DR PRIDE; Q96PQ6; -.
DR ProteomicsDB; 77731; -. [Q96PQ6-1]
DR ProteomicsDB; 77732; -. [Q96PQ6-2]
DR ProteomicsDB; 77733; -. [Q96PQ6-3]
DR ProteomicsDB; 77734; -. [Q96PQ6-4]
DR Antibodypedia; 24999; 108 antibodies from 16 providers.
DR DNASU; 57693; -.
DR Ensembl; ENST00000247956.11; ENSP00000247956.5; ENSG00000130803.15. [Q96PQ6-1]
DR Ensembl; ENST00000360385.7; ENSP00000353554.2; ENSG00000130803.15. [Q96PQ6-2]
DR GeneID; 57693; -.
DR KEGG; hsa:57693; -.
DR MANE-Select; ENST00000247956.11; ENSP00000247956.5; NM_020933.5; NP_065984.3.
DR UCSC; uc002mku.4; human. [Q96PQ6-1]
DR CTD; 57693; -.
DR DisGeNET; 57693; -.
DR GeneCards; ZNF317; -.
DR HGNC; HGNC:13507; ZNF317.
DR HPA; ENSG00000130803; Low tissue specificity.
DR MIM; 613864; gene.
DR neXtProt; NX_Q96PQ6; -.
DR OpenTargets; ENSG00000130803; -.
DR PharmGKB; PA37793; -.
DR VEuPathDB; HostDB:ENSG00000130803; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162241; -.
DR HOGENOM; CLU_002678_72_0_1; -.
DR InParanoid; Q96PQ6; -.
DR OMA; KKPIECR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96PQ6; -.
DR TreeFam; TF338497; -.
DR PathwayCommons; Q96PQ6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96PQ6; -.
DR BioGRID-ORCS; 57693; 258 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF317; human.
DR GenomeRNAi; 57693; -.
DR Pharos; Q96PQ6; Tdark.
DR PRO; PR:Q96PQ6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96PQ6; protein.
DR Bgee; ENSG00000130803; Expressed in granulocyte and 171 other tissues.
DR ExpressionAtlas; Q96PQ6; baseline and differential.
DR Genevisible; Q96PQ6; HS.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..595
FT /note="Zinc finger protein 317"
FT /id="PRO_0000047526"
FT DOMAIN 57..128
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 222..244
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..272
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 334..356
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 362..384
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 390..412
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 418..440
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 502..524
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 530..552
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 558..580
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 109..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:11688974"
FT /id="VSP_006915"
FT VAR_SEQ 97..128
FT /note="Missing (in isoform 1 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:10997877,
FT ECO:0000303|PubMed:11688974, ECO:0000303|PubMed:15489334"
FT /id="VSP_006916"
FT VARIANT 19
FT /note="Q -> H (in dbSNP:rs3752199)"
FT /id="VAR_019980"
FT CONFLICT 409
FT /note="M -> I (in Ref. 1; AAL29182/AAL29188/AAL29190/
FT AAL29191)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 595 AA; 67959 MW; 9AF99586A1882A9D CRC64;
MAALSPTFAT STQDSTCLQD SEFPVSSKDH SCPQNLDLFV CSGLEPHTPS VGSQESVTFQ
DVAVDFTEKE WPLLDSSQRK LYKDVMLENY SNLTSLGYQV GKPSLISHLE QEEEPRTEER
GAHQGACADW ETPSKTKWSL LMEDIFGKET PSGVTMERAG LGEKSTEYAH LFEVFGMDPH
LTQPMGRHAG KRPYHRRDYG VAFKGRPHLT QHMSMYDGRK MHECHQCQKA FTTSASLTRH
RRIHTGEKPY ECSDCGKAFN DPSALRSHAR THLKEKPFDC SQCGNAFRTL SALKIHMRVH
TGERPYKCDQ CGKAYGRSCH LIAHKRTHTG ERPYECHDCG KAFQHPSHLK EHVRNHTGEK
PYACTQCGKA FRWKSNFNLH KKNHMVEKTY ECKECGKSFG DLVSRRKHMR IHIVKKPVEC
RQCGKTFRNQ SILKTHMNSH TGEKPYGCDL CGKAFSASSN LTAHRKIHTQ ERRYECAACG
KVFGDYLSRR RHMSVHLVKK RVECRQCGKA FRNQSTLKTH MRSHTGEKPY ECDHCGKAFS
IGSNLNVHRR IHTGEKPYEC LVCGKAFSDH SSLRSHVKTH RGEKLFVSSV WKRLQ
