ZN320_HUMAN
ID ZN320_HUMAN Reviewed; 509 AA.
AC A2RRD8; Q8NDR6;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Zinc finger protein 320;
GN Name=ZNF320;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-509.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP TISSUE SPECIFICITY, AND CHROMOSOMAL TRANSLOCATION WITH BRWD2/WDR11.
RX PubMed=11536051; DOI=10.1038/sj.onc.1204694;
RA Chernova O.B., Hunyadi A., Malaj E., Pan H., Crooks C., Roe B.,
RA Cowell J.K.;
RT "A novel member of the WD-repeat gene family, WDR11, maps to the 10q26
RT region and is disrupted by a chromosome translocation in human glioblastoma
RT cells.";
RL Oncogene 20:5378-5392(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC A2RRD8; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10173019, EBI-10172150;
CC A2RRD8; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10173019, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in placenta, pancreas,
CC kidney and heart, and at lower levels in liver, skeletal muscle and
CC brain. {ECO:0000269|PubMed:11536051}.
CC -!- DISEASE: Note=A chromosomal aberration involving ZNF320 is found in a
CC form of glioblastoma. Translocation t(10;19)(q26;q13.3) with
CC BRWD2/WDR11. {ECO:0000269|PubMed:11536051}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC131555; AAI31556.1; -; mRNA.
DR EMBL; AL831902; CAD38570.1; -; mRNA.
DR CCDS; CCDS33095.1; -.
DR RefSeq; NP_997216.2; NM_207333.2.
DR RefSeq; XP_006723122.1; XM_006723059.3.
DR RefSeq; XP_016881882.1; XM_017026393.1.
DR RefSeq; XP_016881883.1; XM_017026394.1.
DR RefSeq; XP_016881884.1; XM_017026395.1.
DR RefSeq; XP_016881885.1; XM_017026396.1.
DR RefSeq; XP_016881886.1; XM_017026397.1.
DR RefSeq; XP_016881887.1; XM_017026398.1.
DR RefSeq; XP_016881888.1; XM_017026399.1.
DR RefSeq; XP_016881889.1; XM_017026400.1.
DR AlphaFoldDB; A2RRD8; -.
DR SMR; A2RRD8; -.
DR BioGRID; 127834; 44.
DR IntAct; A2RRD8; 3.
DR STRING; 9606.ENSP00000473091; -.
DR iPTMnet; A2RRD8; -.
DR PhosphoSitePlus; A2RRD8; -.
DR BioMuta; ZNF320; -.
DR EPD; A2RRD8; -.
DR jPOST; A2RRD8; -.
DR MassIVE; A2RRD8; -.
DR MaxQB; A2RRD8; -.
DR PaxDb; A2RRD8; -.
DR PeptideAtlas; A2RRD8; -.
DR PRIDE; A2RRD8; -.
DR ProteomicsDB; 462; -.
DR Antibodypedia; 46227; 42 antibodies from 16 providers.
DR DNASU; 162967; -.
DR Ensembl; ENST00000391781.6; ENSP00000375660.2; ENSG00000182986.15.
DR Ensembl; ENST00000595635.5; ENSP00000473091.1; ENSG00000182986.15.
DR Ensembl; ENST00000682928.1; ENSP00000506814.1; ENSG00000182986.15.
DR GeneID; 162967; -.
DR KEGG; hsa:162967; -.
DR MANE-Select; ENST00000682928.1; ENSP00000506814.1; NM_001351774.2; NP_001338703.1.
DR UCSC; uc002qai.4; human.
DR CTD; 162967; -.
DR GeneCards; ZNF320; -.
DR HGNC; HGNC:13842; ZNF320.
DR HPA; ENSG00000182986; Low tissue specificity.
DR MIM; 606427; gene.
DR neXtProt; NX_A2RRD8; -.
DR OpenTargets; ENSG00000182986; -.
DR PharmGKB; PA37819; -.
DR VEuPathDB; HostDB:ENSG00000182986; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163506; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; A2RRD8; -.
DR OMA; YHIGALC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A2RRD8; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; A2RRD8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A2RRD8; -.
DR BioGRID-ORCS; 162967; 51 hits in 1064 CRISPR screens.
DR ChiTaRS; ZNF320; human.
DR GenomeRNAi; 162967; -.
DR Pharos; A2RRD8; Tdark.
DR PRO; PR:A2RRD8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A2RRD8; protein.
DR Bgee; ENSG00000182986; Expressed in buccal mucosa cell and 166 other tissues.
DR ExpressionAtlas; A2RRD8; baseline and differential.
DR Genevisible; A2RRD8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Chromosomal rearrangement; DNA-binding; Metal-binding; Nucleus;
KW Proto-oncogene; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..509
FT /note="Zinc finger protein 320"
FT /id="PRO_0000300263"
FT DOMAIN 8..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 161..183
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 245..267
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 273..295
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 301..323
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 329..351
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 357..379
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 385..407
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 413..435
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 441..463
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 469..491
FT /note="C2H2-type 12; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 509 AA; 59326 MW; 2D221BC43C684B61 CRC64;
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMNTLSS
TGQGNTEVIH TGTLQRQASY HIGAFCSQEI EKDIHDFVFQ WQEDETNDHE APMTEIKKLT
SSTDRYDQRH AGNKPIKGQL ESRFHLHLRR HRRIHTGEKP YKCEECEKVF SCKSHLEIHR
IIHTGEKPYK CKVCDKAFKH DSHLAKHTRI HRGDKHYTCN ECGKVFDQKA TLACHHRSHT
GEKPYKCNEC GKTFSQTSHL VYHHRLHTGE KPYKCNECGK TFARNSVLVI HKAVHTAEKP
YKCNECGKVF KQRATLAGHR RVHTGEKPYR CEECDKVFSR KSHLERHRRI HTGEKPYKCK
VCDKAFRSDS RLAEHQRVHT GERPYTCNEC GKVFSTKAYL ACHQKLHTGE KLYECEECDK
VYIRKSHLER HRRIHTGEKP HKCGDCGKAF NSPSHLIRHQ RIHTGQKSYK CHQCGKVFSL
RSLLAEHQKI PFGDNCFKCN EYSKPSSIN
