ZN329_HUMAN
ID ZN329_HUMAN Reviewed; 541 AA.
AC Q86UD4; B3KR32; Q9H9R7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Zinc finger protein 329;
GN Name=ZNF329;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, Brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q86UD4; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-7233259, EBI-3866279;
CC Q86UD4; Q8NHQ1: CEP70; NbExp=7; IntAct=EBI-7233259, EBI-739624;
CC Q86UD4; Q96Q77: CIB3; NbExp=3; IntAct=EBI-7233259, EBI-10292696;
CC Q86UD4; P50402: EMD; NbExp=3; IntAct=EBI-7233259, EBI-489887;
CC Q86UD4; O15287: FANCG; NbExp=3; IntAct=EBI-7233259, EBI-81610;
CC Q86UD4; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-7233259, EBI-5916454;
CC Q86UD4; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-7233259, EBI-715394;
CC Q86UD4; Q6A162: KRT40; NbExp=3; IntAct=EBI-7233259, EBI-10171697;
CC Q86UD4; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-7233259, EBI-10172150;
CC Q86UD4; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-7233259, EBI-10172290;
CC Q86UD4; P50222: MEOX2; NbExp=3; IntAct=EBI-7233259, EBI-748397;
CC Q86UD4; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-7233259, EBI-742948;
CC Q86UD4; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-7233259, EBI-11522433;
CC Q86UD4; Q96CV9: OPTN; NbExp=3; IntAct=EBI-7233259, EBI-748974;
CC Q86UD4; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-7233259, EBI-79165;
CC Q86UD4; P31321: PRKAR1B; NbExp=3; IntAct=EBI-7233259, EBI-2805516;
CC Q86UD4; Q13470-2: TNK1; NbExp=3; IntAct=EBI-7233259, EBI-11018037;
CC Q86UD4; O94972: TRIM37; NbExp=3; IntAct=EBI-7233259, EBI-741602;
CC Q86UD4; Q8WV44: TRIM41; NbExp=4; IntAct=EBI-7233259, EBI-725997;
CC Q86UD4; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-7233259, EBI-947459;
CC Q86UD4; P13994: YJU2B; NbExp=5; IntAct=EBI-7233259, EBI-716093;
CC Q86UD4; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-7233259, EBI-742740;
CC Q86UD4; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-7233259, EBI-10183064;
CC Q86UD4; Q9NSD4: ZNF275; NbExp=3; IntAct=EBI-7233259, EBI-17263125;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB14154.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK022648; BAB14154.1; ALT_INIT; mRNA.
DR EMBL; AK090893; BAG52244.1; -; mRNA.
DR EMBL; AK096542; BAG53319.1; -; mRNA.
DR EMBL; AC008751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72560.1; -; Genomic_DNA.
DR EMBL; BC047501; AAH47501.1; -; mRNA.
DR CCDS; CCDS12972.1; -.
DR RefSeq; NP_078896.3; NM_024620.3.
DR RefSeq; XP_006723444.1; XM_006723381.2.
DR RefSeq; XP_006723445.1; XM_006723382.3.
DR RefSeq; XP_006723446.1; XM_006723383.3.
DR RefSeq; XP_006723447.1; XM_006723384.3.
DR RefSeq; XP_011525617.1; XM_011527315.1.
DR RefSeq; XP_011525618.1; XM_011527316.2.
DR RefSeq; XP_016882796.1; XM_017027307.1.
DR RefSeq; XP_016882797.1; XM_017027308.1.
DR RefSeq; XP_016882798.1; XM_017027309.1.
DR RefSeq; XP_016882799.1; XM_017027310.1.
DR RefSeq; XP_016882800.1; XM_017027311.1.
DR AlphaFoldDB; Q86UD4; -.
DR SMR; Q86UD4; -.
DR BioGRID; 122798; 29.
DR IntAct; Q86UD4; 26.
DR MINT; Q86UD4; -.
DR STRING; 9606.ENSP00000470323; -.
DR iPTMnet; Q86UD4; -.
DR PhosphoSitePlus; Q86UD4; -.
DR BioMuta; ZNF329; -.
DR DMDM; 296453050; -.
DR EPD; Q86UD4; -.
DR MassIVE; Q86UD4; -.
DR MaxQB; Q86UD4; -.
DR PaxDb; Q86UD4; -.
DR PeptideAtlas; Q86UD4; -.
DR PRIDE; Q86UD4; -.
DR ProteomicsDB; 69802; -.
DR Antibodypedia; 19680; 209 antibodies from 24 providers.
DR DNASU; 79673; -.
DR Ensembl; ENST00000358067.5; ENSP00000350773.4; ENSG00000181894.15.
DR Ensembl; ENST00000500161.2; ENSP00000439527.1; ENSG00000181894.15.
DR Ensembl; ENST00000597186.5; ENSP00000470323.1; ENSG00000181894.15.
DR Ensembl; ENST00000598312.6; ENSP00000470008.1; ENSG00000181894.15.
DR GeneID; 79673; -.
DR KEGG; hsa:79673; -.
DR MANE-Select; ENST00000598312.6; ENSP00000470008.1; NM_024620.4; NP_078896.3.
DR UCSC; uc002qrn.4; human.
DR CTD; 79673; -.
DR DisGeNET; 79673; -.
DR GeneCards; ZNF329; -.
DR HGNC; HGNC:14209; ZNF329.
DR HPA; ENSG00000181894; Low tissue specificity.
DR neXtProt; NX_Q86UD4; -.
DR OpenTargets; ENSG00000181894; -.
DR PharmGKB; PA37858; -.
DR VEuPathDB; HostDB:ENSG00000181894; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162872; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q86UD4; -.
DR OMA; CDVEMEG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q86UD4; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q86UD4; -.
DR SignaLink; Q86UD4; -.
DR BioGRID-ORCS; 79673; 12 hits in 1103 CRISPR screens.
DR ChiTaRS; ZNF329; human.
DR GenomeRNAi; 79673; -.
DR Pharos; Q86UD4; Tdark.
DR PRO; PR:Q86UD4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86UD4; protein.
DR Bgee; ENSG00000181894; Expressed in endothelial cell and 190 other tissues.
DR ExpressionAtlas; Q86UD4; baseline and differential.
DR Genevisible; Q86UD4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..541
FT /note="Zinc finger protein 329"
FT /id="PRO_0000307288"
FT ZN_FING 203..225
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 371..393
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 399..421
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6GQR8"
FT VARIANT 99
FT /note="S -> N (in dbSNP:rs2279333)"
FT /id="VAR_060428"
FT VARIANT 182
FT /note="N -> D (in dbSNP:rs34255209)"
FT /id="VAR_035403"
FT CONFLICT 122
FT /note="S -> N (in Ref. 4; AAH47501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 541 AA; 61725 MW; 4C56F21B845BF69F CRC64;
MRLKMTTRNF PEREVPCDVE VERFTREVPC LSSLGDGWDC ENQEGHLRQS ALTLEKPGTQ
EAICEYPGFG EHLIASSDLP PSQRVLATNG FHAPDSNVSG LDCDPALPSY PKSYADKRTG
DSDACGKGFN HSMEVIHGRN PVREKPYKYP ESVKSFNHFT SLGHQKIMKR GKKSYEGKNF
ENIFTLSSSL NENQRNLPGE KQYRCTECGK CFKRNSSLVL HHRTHTGEKP YTCNECGKSF
SKNYNLIVHQ RIHTGEKPYE CSKCGKAFSD GSALTQHQRI HTGEKPYECL ECGKTFNRNS
SLILHQRTHT GEKPYRCNEC GKPFTDISHL TVHLRIHTGE KPYECSKCGK AFRDGSYLTQ
HERTHTGEKP FECAECGKSF NRNSHLIVHQ KIHSGEKPYE CKECGKTFIE SAYLIRHQRI
HTGEKPYGCN QCQKLFRNIA GLIRHQRTHT GEKPYECNQC GKAFRDSSCL TKHQRIHTKE
TPYQCPECGK SFKQNSHLAV HQRLHSREGP SRCPQCGKMF QKSSSLVRHQ RAHLGEQPME
T
