ZN329_MOUSE
ID ZN329_MOUSE Reviewed; 522 AA.
AC Q6GQR8; Q8BKL5; Q9D459;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 329;
GN Name=Znf329; Synonyms=Zfp329;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB30425.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK016779; BAB30425.1; ALT_FRAME; mRNA.
DR EMBL; AK051535; BAC34666.1; -; mRNA.
DR EMBL; BC072665; AAH72665.2; -; mRNA.
DR CCDS; CCDS20813.1; -.
DR RefSeq; NP_080322.2; NM_026046.3.
DR AlphaFoldDB; Q6GQR8; -.
DR SMR; Q6GQR8; -.
DR STRING; 10090.ENSMUSP00000072079; -.
DR iPTMnet; Q6GQR8; -.
DR PhosphoSitePlus; Q6GQR8; -.
DR jPOST; Q6GQR8; -.
DR PaxDb; Q6GQR8; -.
DR PRIDE; Q6GQR8; -.
DR ProteomicsDB; 275282; -.
DR Antibodypedia; 19680; 209 antibodies from 24 providers.
DR DNASU; 67230; -.
DR Ensembl; ENSMUST00000072222; ENSMUSP00000072079; ENSMUSG00000057894.
DR Ensembl; ENSMUST00000121215; ENSMUSP00000113355; ENSMUSG00000057894.
DR GeneID; 67230; -.
DR KEGG; mmu:67230; -.
DR UCSC; uc009feh.2; mouse.
DR CTD; 67230; -.
DR MGI; MGI:1921283; Zfp329.
DR VEuPathDB; HostDB:ENSMUSG00000057894; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162872; -.
DR HOGENOM; CLU_002678_44_11_1; -.
DR InParanoid; Q6GQR8; -.
DR OMA; CDVEMEG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6GQR8; -.
DR TreeFam; TF337055; -.
DR BioGRID-ORCS; 67230; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp329; mouse.
DR PRO; PR:Q6GQR8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6GQR8; protein.
DR Bgee; ENSMUSG00000057894; Expressed in saccule of membranous labyrinth and 239 other tissues.
DR ExpressionAtlas; Q6GQR8; baseline and differential.
DR Genevisible; Q6GQR8; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..522
FT /note="Zinc finger protein 329"
FT /id="PRO_0000307289"
FT ZN_FING 184..206
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 181
FT /note="E -> G (in Ref. 1; BAC34666)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 522 AA; 59832 MW; 0A11FC4AEB01F738 CRC64;
MEGFTREAPC FPILGDNWDC ENQERNLRQS PLIDEKTEAQ EANCGHVNLG EHLSTNPALL
PSQRVPGTNG FHVFNSDIKT FDCDQTLHSC PPSYAVKGTA DGDACEKATQ PSMEATQLVR
NQMREKSYKY TESVKSLNHF TTALCDKKIK KRSKRFYKGK DFGDILALSS SLNEKRSHSA
EKPYKCAECG KCFKRNSSLV LHHRTHTGEK PYTCNDCGKS FSKNYNLIVH RRIHTGEKPY
KCSKCGKAFS DGSALTQHQR IHTGEKPYAC LDCGKTFNRN SSLILHQRTH TGEKPYRCNE
CGKPFTDISH LTVHLRIHTG EKPYECSRCG KAFRDGSYLT QHERTHTGEK PFECVECGKS
FSRNSHLIVH QKIHSGEKPY ECKECGKTFI ESAYLIRHQR VHTGEKPYGC NQCRKLFRNI
AGLIRHQRIH TGERPYECNQ CGKAFRDSSC LTKHQRIHTK ETPYQCLKCG KSFRQNTHLV
VHQRLHNREG PSQCPHCGKI FRRSWCLARH QRTHLEEQPT ET
