ZN330_CRIGR
ID ZN330_CRIGR Reviewed; 317 AA.
AC O70524;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Zinc finger protein 330;
DE AltName: Full=Nucleolar autoantigen 36;
DE AltName: Full=Nucleolar cysteine-rich protein;
GN Name=ZNF330; Synonyms=NOA36;
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=10593942; DOI=10.1074/jbc.274.51.36456;
RA Bolivar J., Diaz I., Iglesias C., Valdivia M.M.;
RT "Molecular cloning of a zinc finger autoantigen transiently associated with
RT interphase nucleolus and mitotic centromeres and midbodies. Orthologous
RT proteins with nine CXXC motifs highly conserved from nematodes to humans.";
RL J. Biol. Chem. 274:36456-36464(1999).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Predominantly
CC expressed in nucleolus. In mitosis associated with centromeres and
CC concentrated at the midbody in cytokinesis (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOA36 family. {ECO:0000305}.
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DR EMBL; Y12836; CAA73357.1; -; mRNA.
DR RefSeq; NP_001231227.1; NM_001244298.1.
DR AlphaFoldDB; O70524; -.
DR STRING; 10029.NP_001231227.1; -.
DR GeneID; 100689256; -.
DR KEGG; cge:100689256; -.
DR CTD; 27309; -.
DR eggNOG; ENOG502QRJT; Eukaryota.
DR OrthoDB; 935225at2759; -.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR010531; NOA36.
DR PANTHER; PTHR13214; PTHR13214; 1.
DR Pfam; PF06524; NOA36; 1.
PE 2: Evidence at transcript level;
KW Centromere; Chromosome; Metal-binding; Nucleus; Phosphoprotein; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..317
FT /note="Zinc finger protein 330"
FT /id="PRO_0000066588"
FT ZN_FING 42..58
FT /note="C4-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 67..104
FT /note="C4-type 2"
FT /evidence="ECO:0000255"
FT ZN_FING 129..149
FT /note="C4-type 3"
FT /evidence="ECO:0000255"
FT ZN_FING 175..189
FT /note="C4-type 4"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3..11
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 206..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..289
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 288
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y3S2"
SQ SEQUENCE 317 AA; 35707 MW; EB4CAC64E97B47EF CRC64;
MPKKKTGPRK KAENRREREK QLRASRSTVD LAKHPCNASM ECDKCQRRQK NRAFCYFCNS
VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR
LGQHSCLRCK ACFCDEHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG
GEEGDGASGY DAYWKNLSSD EYADTGYHDD EEEDEAEDEE EEEDGKDSDA ESSDLFTSLN
LGRTYASGYA HYEEQEN
