ZN330_DROME
ID ZN330_DROME Reviewed; 315 AA.
AC Q9VAU9; O97181;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Zinc finger protein 330 homolog;
DE AltName: Full=Nucleolar autoantigen 36 homolog;
GN Name=Noa36; ORFNames=CG10009;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=10593942; DOI=10.1074/jbc.274.51.36456;
RA Bolivar J., Diaz I., Iglesias C., Valdivia M.M.;
RT "Molecular cloning of a zinc finger autoantigen transiently associated with
RT interphase nucleolus and mitotic centromeres and midbodies. Orthologous
RT proteins with nine CXXC motifs highly conserved from nematodes to humans.";
RL J. Biol. Chem. 274:36456-36464(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}. Note=Predominantly expressed in the nucleolus.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOA36 family. {ECO:0000305}.
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DR EMBL; AJ131564; CAB39165.1; -; mRNA.
DR EMBL; AE014297; AAF56799.1; -; Genomic_DNA.
DR EMBL; AY122179; AAM52691.1; -; mRNA.
DR RefSeq; NP_651622.2; NM_143365.3.
DR AlphaFoldDB; Q9VAU9; -.
DR BioGRID; 68260; 12.
DR DIP; DIP-17066N; -.
DR IntAct; Q9VAU9; 20.
DR STRING; 7227.FBpp0084689; -.
DR PaxDb; Q9VAU9; -.
DR DNASU; 43384; -.
DR EnsemblMetazoa; FBtr0085320; FBpp0084689; FBgn0026400.
DR GeneID; 43384; -.
DR KEGG; dme:Dmel_CG10009; -.
DR CTD; 43384; -.
DR FlyBase; FBgn0026400; Noa36.
DR VEuPathDB; VectorBase:FBgn0026400; -.
DR eggNOG; ENOG502QRJT; Eukaryota.
DR GeneTree; ENSGT00390000017043; -.
DR HOGENOM; CLU_074902_0_0_1; -.
DR InParanoid; Q9VAU9; -.
DR OMA; DHIRRKG; -.
DR OrthoDB; 935225at2759; -.
DR PhylomeDB; Q9VAU9; -.
DR SignaLink; Q9VAU9; -.
DR BioGRID-ORCS; 43384; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Noa36; fly.
DR GenomeRNAi; 43384; -.
DR PRO; PR:Q9VAU9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0026400; Expressed in egg cell and 43 other tissues.
DR Genevisible; Q9VAU9; DM.
DR GO; GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0035167; P:larval lymph gland hemopoiesis; IMP:FlyBase.
DR InterPro; IPR010531; NOA36.
DR PANTHER; PTHR13214; PTHR13214; 1.
DR Pfam; PF06524; NOA36; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..315
FT /note="Zinc finger protein 330 homolog"
FT /id="PRO_0000066589"
FT ZN_FING 40..56
FT /note="C4-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 65..102
FT /note="C4-type 2"
FT /evidence="ECO:0000255"
FT ZN_FING 127..147
FT /note="C4-type 3"
FT /evidence="ECO:0000255"
FT ZN_FING 173..187
FT /note="C4-type 4"
FT /evidence="ECO:0000255"
FT REGION 228..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3..11
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 228..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..304
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 16..17
FT /note="KL -> NV (in Ref. 1; CAB39165)"
FT /evidence="ECO:0000305"
FT CONFLICT 256..257
FT /note="Missing (in Ref. 1; CAB39165)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 35355 MW; F3C24D965FD22925 CRC64;
MPKKKTGQRK KAEKQKLRLK EIRSREVPLA DLPCNAPMEC DKCEKKQKSR AFCYFCQSIQ
RLPICAQCGK IKCMLKTGDC VVKHPGVYTT GLGMVGAICD FCEAWVCHGR KCLQNHACTC
PLQNATCLEC ERGVWEHGGR IFKCSFCNGF LCEDDQFEHQ ASCQVLESEN YKCQSCNKLG
QYSCLRCKTC YCEDHVRRKG FKYDKNKPIP CPKCNYDTSV TKDLSMSTRS HKFGRQQQGG
NSDDEEGYGG YYGAGGSGYY GGAASGGYSY GGDDDEDESD GDYDDESDED DDDDEEEDET
TESEPEKETD KKATK
