ZN330_HUMAN
ID ZN330_HUMAN Reviewed; 320 AA.
AC Q9Y3S2; B2RDA3;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 330;
DE AltName: Full=Nucleolar autoantigen 36;
DE AltName: Full=Nucleolar cysteine-rich protein;
GN Name=ZNF330; Synonyms=NOA36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10593942; DOI=10.1074/jbc.274.51.36456;
RA Bolivar J., Diaz I., Iglesias C., Valdivia M.M.;
RT "Molecular cloning of a zinc finger autoantigen transiently associated with
RT interphase nucleolus and mitotic centromeres and midbodies. Orthologous
RT proteins with nine CXXC motifs highly conserved from nematodes to humans.";
RL J. Biol. Chem. 274:36456-36464(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Bolivar J.;
RT "Genomic structure and chromosomal localization of the human zinc finger
RT autoantigen NOA36.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9Y3S2; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-373456, EBI-10173507;
CC Q9Y3S2; P48745: CCN3; NbExp=3; IntAct=EBI-373456, EBI-3904822;
CC Q9Y3S2; P27918: CFP; NbExp=3; IntAct=EBI-373456, EBI-9038570;
CC Q9Y3S2; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-373456, EBI-741528;
CC Q9Y3S2; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-373456, EBI-741032;
CC Q9Y3S2; Q02930-3: CREB5; NbExp=3; IntAct=EBI-373456, EBI-10192698;
CC Q9Y3S2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-373456, EBI-3867333;
CC Q9Y3S2; Q9UIH9: KLF15; NbExp=5; IntAct=EBI-373456, EBI-2796400;
CC Q9Y3S2; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-373456, EBI-11959885;
CC Q9Y3S2; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-373456, EBI-11749135;
CC Q9Y3S2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-373456, EBI-10171774;
CC Q9Y3S2; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-373456, EBI-10241252;
CC Q9Y3S2; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-373456, EBI-11987425;
CC Q9Y3S2; Q99750: MDFI; NbExp=3; IntAct=EBI-373456, EBI-724076;
CC Q9Y3S2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-373456, EBI-16439278;
CC Q9Y3S2; P17568: NDUFB7; NbExp=3; IntAct=EBI-373456, EBI-1246238;
CC Q9Y3S2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-373456, EBI-22310682;
CC Q9Y3S2; Q92570: NR4A3; NbExp=3; IntAct=EBI-373456, EBI-13644623;
CC Q9Y3S2; P32242: OTX1; NbExp=3; IntAct=EBI-373456, EBI-740446;
CC Q9Y3S2; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-373456, EBI-10302990;
CC Q9Y3S2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-373456, EBI-79165;
CC Q9Y3S2; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-373456, EBI-1210429;
CC Q9Y3S2; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-373456, EBI-12009390;
CC Q9Y3S2; Q2I0M5: RSPO4; NbExp=3; IntAct=EBI-373456, EBI-12821217;
CC Q9Y3S2; Q6NW29: RWDD4; NbExp=6; IntAct=EBI-373456, EBI-743971;
CC Q9Y3S2; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-373456, EBI-14123856;
CC Q9Y3S2; O43609: SPRY1; NbExp=3; IntAct=EBI-373456, EBI-3866665;
CC Q9Y3S2; O75716: STK16; NbExp=6; IntAct=EBI-373456, EBI-749295;
CC Q9Y3S2; Q8N4C7: STX19; NbExp=3; IntAct=EBI-373456, EBI-8484990;
CC Q9Y3S2; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-373456, EBI-740595;
CC Q9Y3S2; O95988: TCL1B; NbExp=6; IntAct=EBI-373456, EBI-727338;
CC Q9Y3S2; Q08117-2: TLE5; NbExp=5; IntAct=EBI-373456, EBI-11741437;
CC Q9Y3S2; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-373456, EBI-5235829;
CC Q9Y3S2; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-373456, EBI-12287587;
CC Q9Y3S2; P17027: ZNF23; NbExp=3; IntAct=EBI-373456, EBI-5657766;
CC Q9Y3S2; P15622-3: ZNF250; NbExp=3; IntAct=EBI-373456, EBI-10177272;
CC Q9Y3S2; Q9H9D4: ZNF408; NbExp=4; IntAct=EBI-373456, EBI-347633;
CC Q9Y3S2; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-373456, EBI-743265;
CC Q9Y3S2; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-373456, EBI-726439;
CC Q9Y3S2; Q14592: ZNF460; NbExp=3; IntAct=EBI-373456, EBI-2555738;
CC Q9Y3S2; Q8IVP9: ZNF547; NbExp=5; IntAct=EBI-373456, EBI-12895421;
CC Q9Y3S2; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-373456, EBI-6427977;
CC Q9Y3S2; Q8N720: ZNF655; NbExp=3; IntAct=EBI-373456, EBI-625509;
CC Q9Y3S2; Q8N3J9: ZNF664; NbExp=3; IntAct=EBI-373456, EBI-2799450;
CC Q9Y3S2; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-373456, EBI-12006574;
CC Q9Y3S2; Q8IZ20: ZNF683; NbExp=3; IntAct=EBI-373456, EBI-12005952;
CC Q9Y3S2; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-373456, EBI-4395732;
CC Q9Y3S2; Q96H86: ZNF764; NbExp=3; IntAct=EBI-373456, EBI-745775;
CC Q9Y3S2; Q9H5H4: ZNF768; NbExp=3; IntAct=EBI-373456, EBI-1210580;
CC Q9Y3S2; Q96EG3: ZNF837; NbExp=6; IntAct=EBI-373456, EBI-11962574;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10593942}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:10593942}. Chromosome, centromere
CC {ECO:0000269|PubMed:10593942}. Note=Predominantly expressed in the
CC nucleolus. In mitosis associated with centromeres and concentrated at
CC the midbody in cytokinesis.
CC -!- TISSUE SPECIFICITY: Widely expressed. Higher expression seen in heart
CC and skeletal muscle. {ECO:0000269|PubMed:10593942}.
CC -!- SIMILARITY: Belongs to the NOA36 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ006591; CAB43112.1; -; mRNA.
DR EMBL; AJ404873; CAC18679.1; -; Genomic_DNA.
DR EMBL; AJ404874; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AJ404875; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AJ404876; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AJ404877; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AJ404878; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AJ404879; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AJ404880; CAC18679.1; JOINED; Genomic_DNA.
DR EMBL; AK315463; BAG37850.1; -; mRNA.
DR EMBL; CH471056; EAX05089.1; -; Genomic_DNA.
DR EMBL; BC004421; AAH04421.1; -; mRNA.
DR CCDS; CCDS3754.1; -.
DR RefSeq; NP_001278931.1; NM_001292002.1.
DR RefSeq; NP_055302.1; NM_014487.5.
DR RefSeq; XP_016863522.1; XM_017008033.1.
DR AlphaFoldDB; Q9Y3S2; -.
DR BioGRID; 118131; 433.
DR IntAct; Q9Y3S2; 53.
DR MINT; Q9Y3S2; -.
DR STRING; 9606.ENSP00000262990; -.
DR GlyGen; Q9Y3S2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Y3S2; -.
DR PhosphoSitePlus; Q9Y3S2; -.
DR SwissPalm; Q9Y3S2; -.
DR BioMuta; ZNF330; -.
DR DMDM; 51702204; -.
DR EPD; Q9Y3S2; -.
DR jPOST; Q9Y3S2; -.
DR MassIVE; Q9Y3S2; -.
DR MaxQB; Q9Y3S2; -.
DR PaxDb; Q9Y3S2; -.
DR PeptideAtlas; Q9Y3S2; -.
DR PRIDE; Q9Y3S2; -.
DR ProteomicsDB; 86075; -.
DR Antibodypedia; 2840; 37 antibodies from 14 providers.
DR DNASU; 27309; -.
DR Ensembl; ENST00000262990.9; ENSP00000262990.4; ENSG00000109445.11.
DR GeneID; 27309; -.
DR KEGG; hsa:27309; -.
DR MANE-Select; ENST00000262990.9; ENSP00000262990.4; NM_014487.6; NP_055302.1.
DR UCSC; uc003iiq.5; human.
DR CTD; 27309; -.
DR GeneCards; ZNF330; -.
DR HGNC; HGNC:15462; ZNF330.
DR HPA; ENSG00000109445; Low tissue specificity.
DR MIM; 609550; gene.
DR neXtProt; NX_Q9Y3S2; -.
DR OpenTargets; ENSG00000109445; -.
DR PharmGKB; PA134925405; -.
DR VEuPathDB; HostDB:ENSG00000109445; -.
DR eggNOG; ENOG502QRJT; Eukaryota.
DR GeneTree; ENSGT00390000017043; -.
DR InParanoid; Q9Y3S2; -.
DR OMA; CQRTRRQ; -.
DR OrthoDB; 935225at2759; -.
DR PhylomeDB; Q9Y3S2; -.
DR TreeFam; TF323303; -.
DR PathwayCommons; Q9Y3S2; -.
DR SignaLink; Q9Y3S2; -.
DR BioGRID-ORCS; 27309; 19 hits in 1082 CRISPR screens.
DR ChiTaRS; ZNF330; human.
DR GeneWiki; ZNF330; -.
DR GenomeRNAi; 27309; -.
DR Pharos; Q9Y3S2; Tdark.
DR PRO; PR:Q9Y3S2; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9Y3S2; protein.
DR Bgee; ENSG00000109445; Expressed in secondary oocyte and 204 other tissues.
DR ExpressionAtlas; Q9Y3S2; baseline and differential.
DR Genevisible; Q9Y3S2; HS.
DR GO; GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
DR GO; GO:0030496; C:midbody; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; NAS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR010531; NOA36.
DR PANTHER; PTHR13214; PTHR13214; 1.
DR Pfam; PF06524; NOA36; 1.
PE 1: Evidence at protein level;
KW Centromere; Chromosome; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..320
FT /note="Zinc finger protein 330"
FT /id="PRO_0000066590"
FT ZN_FING 42..58
FT /note="C4-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 67..104
FT /note="C4-type 2"
FT /evidence="ECO:0000255"
FT ZN_FING 129..149
FT /note="C4-type 3"
FT /evidence="ECO:0000255"
FT ZN_FING 175..189
FT /note="C4-type 4"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3..11
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 206..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..290
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 291
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 28
FT /note="T -> A (in dbSNP:rs35353789)"
FT /id="VAR_051500"
FT VARIANT 298
FT /note="L -> M (in dbSNP:rs34631212)"
FT /id="VAR_051501"
SQ SEQUENCE 320 AA; 36201 MW; CC7F03EE70BF8FD1 CRC64;
MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK NRAFCYFCNS
VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR
LGQHSCLRCK ACFCDDHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG
GEEGDGASGY DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT
NLNLGRTYAS GYAHYEEQEN
