ZN330_MOUSE
ID ZN330_MOUSE Reviewed; 316 AA.
AC Q922H9; Q8C389; Q8K2M4;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Zinc finger protein 330;
DE AltName: Full=Nucleolar autoantigen 36;
DE AltName: Full=Nucleolar cysteine-rich protein;
GN Name=Znf330; Synonyms=Noa36, Zfp330;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N; TISSUE=Limb, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Predominantly
CC expressed in nucleolus. In mitosis associated with centromeres and
CC concentrated at the midbody in cytokinesis (By similarity).
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q922H9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q922H9-2; Sequence=VSP_011428;
CC -!- SIMILARITY: Belongs to the NOA36 family. {ECO:0000305}.
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DR EMBL; AK050534; BAC34313.1; -; mRNA.
DR EMBL; AK086617; BAC39702.1; -; mRNA.
DR EMBL; BC008086; AAH08086.1; -; mRNA.
DR EMBL; BC030675; AAH30675.1; -; mRNA.
DR EMBL; BC083081; AAH83081.1; -; mRNA.
DR CCDS; CCDS22447.1; -. [Q922H9-1]
DR RefSeq; NP_663575.1; NM_145600.1. [Q922H9-1]
DR AlphaFoldDB; Q922H9; -.
DR BioGRID; 206009; 9.
DR STRING; 10090.ENSMUSP00000034147; -.
DR iPTMnet; Q922H9; -.
DR PhosphoSitePlus; Q922H9; -.
DR SwissPalm; Q922H9; -.
DR EPD; Q922H9; -.
DR MaxQB; Q922H9; -.
DR PaxDb; Q922H9; -.
DR PeptideAtlas; Q922H9; -.
DR PRIDE; Q922H9; -.
DR ProteomicsDB; 275007; -. [Q922H9-1]
DR ProteomicsDB; 275008; -. [Q922H9-2]
DR Antibodypedia; 2840; 37 antibodies from 14 providers.
DR DNASU; 30932; -.
DR Ensembl; ENSMUST00000034147; ENSMUSP00000034147; ENSMUSG00000031711. [Q922H9-1]
DR GeneID; 30932; -.
DR KEGG; mmu:30932; -.
DR UCSC; uc009mjo.1; mouse. [Q922H9-1]
DR CTD; 30932; -.
DR MGI; MGI:1353574; Zfp330.
DR VEuPathDB; HostDB:ENSMUSG00000031711; -.
DR eggNOG; ENOG502QRJT; Eukaryota.
DR GeneTree; ENSGT00390000017043; -.
DR HOGENOM; CLU_074902_0_0_1; -.
DR InParanoid; Q922H9; -.
DR OMA; CQRTRRQ; -.
DR OrthoDB; 935225at2759; -.
DR PhylomeDB; Q922H9; -.
DR TreeFam; TF323303; -.
DR BioGRID-ORCS; 30932; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Zfp330; mouse.
DR PRO; PR:Q922H9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q922H9; protein.
DR Bgee; ENSMUSG00000031711; Expressed in epiblast (generic) and 63 other tissues.
DR ExpressionAtlas; Q922H9; baseline and differential.
DR Genevisible; Q922H9; MM.
DR GO; GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.
DR GO; GO:0030496; C:midbody; ISS:UniProtKB.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR010531; NOA36.
DR PANTHER; PTHR13214; PTHR13214; 1.
DR Pfam; PF06524; NOA36; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Centromere; Chromosome; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..316
FT /note="Zinc finger protein 330"
FT /id="PRO_0000066591"
FT ZN_FING 42..58
FT /note="C4-type 1"
FT /evidence="ECO:0000255"
FT ZN_FING 67..104
FT /note="C4-type 2"
FT /evidence="ECO:0000255"
FT ZN_FING 129..149
FT /note="C4-type 3"
FT /evidence="ECO:0000255"
FT ZN_FING 175..189
FT /note="C4-type 4"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3..11
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 266..288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 302..316
FT /note="RTYASGYAHYEEQES -> KSSPVSRDAM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_011428"
SQ SEQUENCE 316 AA; 35608 MW; F247E54E19876D60 CRC64;
MPKKKTGARK KAENRREREK QLRASRSTVD LAKHPCNASM ECDKCQRRQK NRAFCYFCNS
VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI CDFCEAWVCH GRKCLSTHAC
ACPLTDAECV ECERGVWDHG GRIFSCSFCH NFLCEDDQFE HQASCQVLEA ETFKCVSCNR
LGQHSCLRCK ACFCDEHTRS KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG
GEEDGASGYD AYWKNLSSDK YGDTGYHDDD EEEDEAEDEE EEDGKDSDAE SSDLFNNLNL
GRTYASGYAH YEEQES
