ZN333_HUMAN
ID ZN333_HUMAN Reviewed; 665 AA.
AC Q96JL9; Q6P2E6; Q86WS6; Q8TDL0;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2003, sequence version 3.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Zinc finger protein 333;
GN Name=ZNF333; Synonyms=KIAA1806;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12151103; DOI=10.1016/s0167-4781(02)00397-4;
RA Tian Y., Breedveld G.J., Huang S., Oostra B.A., Heutink P., Lo W.H.Y.;
RT "Characterization of ZNF333, a novel double KRAB domain containing zinc
RT finger gene on human chromosome 19p13.1.";
RL Biochim. Biophys. Acta 1577:121-125(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Ovary, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-665 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96JL9-2; P55212: CASP6; NbExp=3; IntAct=EBI-25835852, EBI-718729;
CC Q96JL9-2; P06307: CCK; NbExp=3; IntAct=EBI-25835852, EBI-6624398;
CC Q96JL9-2; O14645: DNALI1; NbExp=3; IntAct=EBI-25835852, EBI-395638;
CC Q96JL9-2; P22607: FGFR3; NbExp=3; IntAct=EBI-25835852, EBI-348399;
CC Q96JL9-2; Q14957: GRIN2C; NbExp=3; IntAct=EBI-25835852, EBI-8285963;
CC Q96JL9-2; P06396: GSN; NbExp=3; IntAct=EBI-25835852, EBI-351506;
CC Q96JL9-2; O14901: KLF11; NbExp=3; IntAct=EBI-25835852, EBI-948266;
CC Q96JL9-2; P13473-2: LAMP2; NbExp=3; IntAct=EBI-25835852, EBI-21591415;
CC Q96JL9-2; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-25835852, EBI-741480;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96JL9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96JL9-2; Sequence=VSP_055945, VSP_055946;
CC Name=3;
CC IsoId=Q96JL9-3; Sequence=VSP_055947, VSP_055948;
CC -!- TISSUE SPECIFICITY: Highly expressed in heart.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF372702; AAM15528.1; -; mRNA.
DR EMBL; AK291471; BAF84160.1; -; mRNA.
DR EMBL; BC048107; AAH48107.1; -; mRNA.
DR EMBL; BC064571; AAH64571.1; -; mRNA.
DR EMBL; AB058709; BAB47435.1; -; mRNA.
DR CCDS; CCDS12316.1; -. [Q96JL9-1]
DR CCDS; CCDS74298.1; -. [Q96JL9-3]
DR RefSeq; NP_001287841.1; NM_001300912.1. [Q96JL9-3]
DR RefSeq; NP_115809.1; NM_032433.2. [Q96JL9-1]
DR RefSeq; XP_011526664.1; XM_011528362.2. [Q96JL9-1]
DR RefSeq; XP_016882856.1; XM_017027367.1. [Q96JL9-1]
DR AlphaFoldDB; Q96JL9; -.
DR SMR; Q96JL9; -.
DR BioGRID; 124087; 52.
DR IntAct; Q96JL9; 13.
DR MINT; Q96JL9; -.
DR STRING; 9606.ENSP00000292530; -.
DR iPTMnet; Q96JL9; -.
DR PhosphoSitePlus; Q96JL9; -.
DR BioMuta; ZNF333; -.
DR DMDM; 29840870; -.
DR jPOST; Q96JL9; -.
DR MassIVE; Q96JL9; -.
DR MaxQB; Q96JL9; -.
DR PaxDb; Q96JL9; -.
DR PeptideAtlas; Q96JL9; -.
DR PRIDE; Q96JL9; -.
DR ProteomicsDB; 76980; -. [Q96JL9-1]
DR Antibodypedia; 26832; 89 antibodies from 19 providers.
DR DNASU; 84449; -.
DR Ensembl; ENST00000292530.11; ENSP00000292530.5; ENSG00000160961.12. [Q96JL9-1]
DR Ensembl; ENST00000540689.6; ENSP00000438130.1; ENSG00000160961.12. [Q96JL9-3]
DR GeneID; 84449; -.
DR KEGG; hsa:84449; -.
DR MANE-Select; ENST00000292530.11; ENSP00000292530.5; NM_032433.4; NP_115809.1.
DR UCSC; uc002mzn.4; human. [Q96JL9-1]
DR CTD; 84449; -.
DR DisGeNET; 84449; -.
DR GeneCards; ZNF333; -.
DR HGNC; HGNC:15624; ZNF333.
DR HPA; ENSG00000160961; Low tissue specificity.
DR MIM; 611811; gene.
DR neXtProt; NX_Q96JL9; -.
DR OpenTargets; ENSG00000160961; -.
DR PharmGKB; PA134929553; -.
DR VEuPathDB; HostDB:ENSG00000160961; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163161; -.
DR HOGENOM; CLU_081476_0_0_1; -.
DR InParanoid; Q96JL9; -.
DR OMA; TTCSQEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96JL9; -.
DR TreeFam; TF350814; -.
DR PathwayCommons; Q96JL9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96JL9; -.
DR BioGRID-ORCS; 84449; 16 hits in 1100 CRISPR screens.
DR ChiTaRS; ZNF333; human.
DR GenomeRNAi; 84449; -.
DR Pharos; Q96JL9; Tdark.
DR PRO; PR:Q96JL9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96JL9; protein.
DR Bgee; ENSG00000160961; Expressed in sural nerve and 113 other tissues.
DR ExpressionAtlas; Q96JL9; baseline and differential.
DR Genevisible; Q96JL9; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 2.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 2.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 2.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..665
FT /note="Zinc finger protein 333"
FT /id="PRO_0000047536"
FT DOMAIN 4..74
FT /note="KRAB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT DOMAIN 203..274
FT /note="KRAB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 366..388
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 562..584
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 590..612
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 618..640
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 142..182
FT /note="GLKAAMQIQRVVIPVPTLGHRNPWVARDSAVPARDPAWLQE -> LPLLSLL
FT LPSCPEPPLVLLDSSSAPDRHLGSTLDTEARGIP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_055945"
FT VAR_SEQ 183..665
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_055946"
FT VAR_SEQ 301..302
FT /note="EQ -> PPN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055947"
FT VAR_SEQ 303..665
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055948"
FT VARIANT 251
FT /note="A -> E (in dbSNP:rs3885179)"
FT /id="VAR_024210"
FT VARIANT 537
FT /note="A -> V (in dbSNP:rs3764626)"
FT /id="VAR_052812"
FT CONFLICT 115
FT /note="S -> P (in Ref. 3; AAH48107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 665 AA; 75544 MW; EE5ABF8468D8DD24 CRC64;
MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS CVSQLGQRAE
PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM QMGPGLFLRM QLVPSIEERE
TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ RVVIPVPTLG HRNPWVARDS AVPARDPAWL
QEDKVEEEAM APGLPTACSQ EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA
SVADQLCKPN ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG
EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS AHLIVPEKIR
SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG QAFKYSSNLR RHMRTHTGEK
PFECSQCGKT FTRNFNLILH QRNHTGEKPY ECKDCGKAFN QPSSLRSHVR THTGEKPFEC
SQCGKAFREH SSLKTHLRTH TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG
QVLSRLSTLK SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG
QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS LPLSMSHPYC
GPLAN
