ZN334_HUMAN
ID ZN334_HUMAN Reviewed; 680 AA.
AC Q9HCZ1; Q5T6U2; Q9NVW4;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 334;
GN Name=ZNF334;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9HCZ1; O95273: CCNDBP1; NbExp=4; IntAct=EBI-748965, EBI-748961;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK001331; BAA91630.1; -; mRNA.
DR EMBL; AL034424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024177; AAH24177.1; -; mRNA.
DR CCDS; CCDS33480.1; -.
DR RefSeq; NP_060572.3; NM_018102.4.
DR RefSeq; XP_016883425.1; XM_017027936.1.
DR RefSeq; XP_016883427.1; XM_017027938.1.
DR AlphaFoldDB; Q9HCZ1; -.
DR SMR; Q9HCZ1; -.
DR BioGRID; 120835; 1.
DR IntAct; Q9HCZ1; 3.
DR STRING; 9606.ENSP00000255129; -.
DR iPTMnet; Q9HCZ1; -.
DR PhosphoSitePlus; Q9HCZ1; -.
DR BioMuta; ZNF334; -.
DR DMDM; 20141040; -.
DR EPD; Q9HCZ1; -.
DR jPOST; Q9HCZ1; -.
DR MassIVE; Q9HCZ1; -.
DR MaxQB; Q9HCZ1; -.
DR PaxDb; Q9HCZ1; -.
DR PeptideAtlas; Q9HCZ1; -.
DR PRIDE; Q9HCZ1; -.
DR ProteomicsDB; 81808; -.
DR Antibodypedia; 28097; 35 antibodies from 14 providers.
DR DNASU; 55713; -.
DR Ensembl; ENST00000347606.8; ENSP00000255129.5; ENSG00000198185.12.
DR Ensembl; ENST00000692313.1; ENSP00000510334.1; ENSG00000198185.12.
DR GeneID; 55713; -.
DR KEGG; hsa:55713; -.
DR MANE-Select; ENST00000692313.1; ENSP00000510334.1; NM_001353824.2; NP_001340753.1.
DR UCSC; uc002xsc.5; human.
DR CTD; 55713; -.
DR DisGeNET; 55713; -.
DR GeneCards; ZNF334; -.
DR HGNC; HGNC:15806; ZNF334.
DR HPA; ENSG00000198185; Low tissue specificity.
DR neXtProt; NX_Q9HCZ1; -.
DR OpenTargets; ENSG00000198185; -.
DR PharmGKB; PA38040; -.
DR VEuPathDB; HostDB:ENSG00000198185; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163620; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; Q9HCZ1; -.
DR OMA; HEQSHLG; -.
DR PhylomeDB; Q9HCZ1; -.
DR TreeFam; TF337898; -.
DR PathwayCommons; Q9HCZ1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9HCZ1; -.
DR BioGRID-ORCS; 55713; 8 hits in 1095 CRISPR screens.
DR ChiTaRS; ZNF334; human.
DR GenomeRNAi; 55713; -.
DR Pharos; Q9HCZ1; Tdark.
DR PRO; PR:Q9HCZ1; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9HCZ1; protein.
DR Bgee; ENSG00000198185; Expressed in right uterine tube and 112 other tissues.
DR ExpressionAtlas; Q9HCZ1; baseline and differential.
DR Genevisible; Q9HCZ1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..680
FT /note="Zinc finger protein 334"
FT /id="PRO_0000047537"
FT DOMAIN 10..81
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 237..259
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 265..287
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 293..315
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 321..343
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 349..371
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 377..399
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 405..427
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 433..455
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 461..483
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..566
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 572..594
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..622
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 628..650
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 656..678
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 547
FT /note="N -> S (in dbSNP:rs3764690)"
FT /id="VAR_052813"
FT CONFLICT 118
FT /note="K -> E (in Ref. 1; BAA91630)"
FT /evidence="ECO:0000305"
FT CONFLICT 426
FT /note="S -> G (in Ref. 1; BAA91630)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 680 AA; 79649 MW; 77DB5086B9261DC6 CRC64;
MKMKKFQIPV SFQDLTVNFT QEEWQQLDPA QRLLYRDVML ENYSNLVSVG YHVSKPDVIF
KLEQGEEPWI VEEFSNQNYP DIDDALEKNK EIQDKHLTQT VFFSNKTLIT ERENVFGKTL
NLGMNSVPSR KMPYKCNPGG NSLKTNSEVI VAKKSKENRK IPDGYSGFGK HEKSHLGMKK
YRYNPMRKAS NQNENLILHQ NIQILKQPFD YNKCGKTFFK RAILITQKGR QTERKPNECN
ECRKTFSKRS TLIVHQRIHT GEKPYVCSDC RKTFRVKTSL TRHRRIHTGE RPYECSECRK
TFIDKSALIV HQKIHGGEKS YECNECGKTF FRKSALAEHF RSHTGEKPYE CKECGNAFSK
KSYLVVHQRT HRGEKPNECK ECGKTFFCQS ALTAHQRIHT GEKPYECSEC EKTFFCQSAL
NVHRRSHTGE KPYECSQCGK FLCTKSALIA HQITHRGKKS YECNECGKFF CHKSTLTIHQ
RTHTGEKHGV FNKCGRISIV KSNCSQCKRM NTKENLYECS EHGHAVSKNS HLIVHQRTIW
ERPYECNECG RTYCRKSALT HHQRTHTGQR PYECNECGKT FCQKFSFVEH QRTHTGEKPY
ECNECGKSFC HKSAFRVHRR IHTGEKPYEC NQCGKTYRRL WTLTEHQKIH TGEKPYECNK
CEKTFRHKSN FLLHQKSHKE
