ZN343_HUMAN
ID ZN343_HUMAN Reviewed; 599 AA.
AC Q6P1L6; Q5JXU8; Q5JXU9; Q8N8F2; Q96EX8; Q96NA5; Q9BQB0;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 343;
GN Name=ZNF343;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Lung, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-435, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6P1L6; Q08043: ACTN3; NbExp=3; IntAct=EBI-10252492, EBI-2880652;
CC Q6P1L6; Q13515: BFSP2; NbExp=3; IntAct=EBI-10252492, EBI-10229433;
CC Q6P1L6; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-10252492, EBI-11977221;
CC Q6P1L6; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-10252492, EBI-6658203;
CC Q6P1L6; O75564-2: JRK; NbExp=3; IntAct=EBI-10252492, EBI-17181882;
CC Q6P1L6; Q9NSK0: KLC4; NbExp=3; IntAct=EBI-10252492, EBI-949319;
CC Q6P1L6; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-10252492, EBI-11750983;
CC Q6P1L6; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-10252492, EBI-744782;
CC Q6P1L6; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-10252492, EBI-10297093;
CC Q6P1L6; Q9UBU9: NXF1; NbExp=3; IntAct=EBI-10252492, EBI-398874;
CC Q6P1L6; P55771: PAX9; NbExp=3; IntAct=EBI-10252492, EBI-12111000;
CC Q6P1L6; O75771: RAD51D; NbExp=3; IntAct=EBI-10252492, EBI-1055693;
CC Q6P1L6; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-10252492, EBI-11984663;
CC Q6P1L6; O00560: SDCBP; NbExp=3; IntAct=EBI-10252492, EBI-727004;
CC Q6P1L6; O75716: STK16; NbExp=3; IntAct=EBI-10252492, EBI-749295;
CC Q6P1L6; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-10252492, EBI-11139477;
CC Q6P1L6; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10252492, EBI-725997;
CC Q6P1L6; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10252492, EBI-741480;
CC Q6P1L6; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-10252492, EBI-14096082;
CC Q6P1L6; Q9P2F9: ZNF319; NbExp=3; IntAct=EBI-10252492, EBI-11993110;
CC Q6P1L6; Q5T619: ZNF648; NbExp=3; IntAct=EBI-10252492, EBI-11985915;
CC Q6P1L6; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-10252492, EBI-5667516;
CC Q6P1L6-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25932668, EBI-5235340;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6P1L6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P1L6-2; Sequence=VSP_016028;
CC Name=3;
CC IsoId=Q6P1L6-3; Sequence=VSP_016029, VSP_016030;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK055734; BAB71000.1; -; mRNA.
DR EMBL; AK096911; BAC04892.1; -; mRNA.
DR EMBL; AL049650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002897; AAH02897.1; -; mRNA.
DR EMBL; BC011862; AAH11862.2; -; mRNA.
DR EMBL; BC065009; AAH65009.1; -; mRNA.
DR CCDS; CCDS13028.1; -. [Q6P1L6-1]
DR CCDS; CCDS74692.1; -. [Q6P1L6-2]
DR CCDS; CCDS74694.1; -. [Q6P1L6-3]
DR RefSeq; NP_001269424.1; NM_001282495.1. [Q6P1L6-1]
DR RefSeq; NP_001269425.1; NM_001282496.1. [Q6P1L6-1]
DR RefSeq; NP_001269426.1; NM_001282497.1.
DR RefSeq; NP_001269427.1; NM_001282498.1. [Q6P1L6-2]
DR RefSeq; NP_001269428.1; NM_001282499.1. [Q6P1L6-3]
DR RefSeq; NP_001308729.1; NM_001321800.1. [Q6P1L6-1]
DR RefSeq; NP_001308730.1; NM_001321801.1.
DR RefSeq; NP_001308731.1; NM_001321802.1.
DR RefSeq; NP_001308732.1; NM_001321803.1.
DR RefSeq; NP_001308734.1; NM_001321805.1.
DR RefSeq; NP_077301.4; NM_024325.5. [Q6P1L6-1]
DR RefSeq; XP_016883551.1; XM_017028062.1.
DR AlphaFoldDB; Q6P1L6; -.
DR SMR; Q6P1L6; -.
DR BioGRID; 122592; 25.
DR IntAct; Q6P1L6; 23.
DR iPTMnet; Q6P1L6; -.
DR PhosphoSitePlus; Q6P1L6; -.
DR BioMuta; ZNF343; -.
DR DMDM; 74762346; -.
DR MassIVE; Q6P1L6; -.
DR PaxDb; Q6P1L6; -.
DR PeptideAtlas; Q6P1L6; -.
DR PRIDE; Q6P1L6; -.
DR ProteomicsDB; 66845; -. [Q6P1L6-1]
DR ProteomicsDB; 66846; -. [Q6P1L6-2]
DR Antibodypedia; 23201; 15 antibodies from 6 providers.
DR DNASU; 79175; -.
DR Ensembl; ENST00000278772.9; ENSP00000278772.4; ENSG00000088876.13. [Q6P1L6-1]
DR Ensembl; ENST00000358413.6; ENSP00000351188.2; ENSG00000088876.13. [Q6P1L6-3]
DR Ensembl; ENST00000381253.5; ENSP00000370652.1; ENSG00000088876.13. [Q6P1L6-3]
DR Ensembl; ENST00000617391.4; ENSP00000483851.1; ENSG00000088876.13. [Q6P1L6-2]
DR GeneID; 79175; -.
DR KEGG; hsa:79175; -.
DR MANE-Select; ENST00000278772.9; ENSP00000278772.4; NM_024325.6; NP_077301.4.
DR UCSC; uc002wge.2; human. [Q6P1L6-1]
DR CTD; 79175; -.
DR GeneCards; ZNF343; -.
DR HGNC; HGNC:16017; ZNF343.
DR HPA; ENSG00000088876; Low tissue specificity.
DR neXtProt; NX_Q6P1L6; -.
DR OpenTargets; ENSG00000088876; -.
DR PharmGKB; PA38081; -.
DR VEuPathDB; HostDB:ENSG00000088876; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163290; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q6P1L6; -.
DR OMA; HYHRSTH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6P1L6; -.
DR TreeFam; TF338096; -.
DR PathwayCommons; Q6P1L6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6P1L6; -.
DR BioGRID-ORCS; 79175; 17 hits in 1103 CRISPR screens.
DR ChiTaRS; ZNF343; human.
DR GenomeRNAi; 79175; -.
DR Pharos; Q6P1L6; Tdark.
DR PRO; PR:Q6P1L6; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q6P1L6; protein.
DR Bgee; ENSG00000088876; Expressed in tibialis anterior and 140 other tissues.
DR ExpressionAtlas; Q6P1L6; baseline and differential.
DR Genevisible; Q6P1L6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..599
FT /note="Zinc finger protein 343"
FT /id="PRO_0000047543"
FT DOMAIN 62..139
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 269..291
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..599
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 169..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 435
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..90
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016028"
FT VAR_SEQ 102..118
FT /note="AEPKPEIYTCSSCLLAF -> GQEIETILANIVKSHLY (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016029"
FT VAR_SEQ 119..599
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_016030"
FT VARIANT 520
FT /note="P -> L (in dbSNP:rs6049415)"
FT /id="VAR_059912"
FT CONFLICT 418
FT /note="F -> S (in Ref. 1; BAC04892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 599 AA; 69220 MW; 121CC71CBA462DF9 CRC64;
MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ KKEGKAQIVV
PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS LAEPKPEIYT CSSCLLAFSC
QQFLSQHVLQ IFLGLCAENH FHPGNSSPGH WKQQGQQYSH VSCWFENAEG QERGGGSKPW
SARTEERETS RAFPSPLQRQ SASPRKGNMV VETEPSSAQR PNPVQLDKGL KELETLRFGA
INCREYEPDH NLESNFITNP RTLLGKKPYI CSDCGRSFKD RSTLIRHHRI HSMEKPYVCS
ECGRGFSQKS NLSRHQRTHS EEKPYLCREC GQSFRSKSIL NRHQWTHSEE KPYVCSECGR
GFSEKSSFIR HQRTHSGEKP YVCLECGRSF CDKSTLRKHQ RIHSGEKPYV CRECGRGFSQ
NSDLIKHQRT HLDEKPYVCR ECGRGFCDKS TLIIHERTHS GEKPYVCGEC GRGFSRKSLL
LVHQRTHSGE KHYVCRECRR GFSQKSNLIR HQRTHSNEKP YICRECGRGF CDKSTLIVHE
RTHSGEKPYV CSECGRGFSR KSLLLVHQRT HSGEKHYVCR ECGRGFSHKS NLIRHQRTH
