ID   CC50C_HUMAN             Reviewed;         113 AA.
AC   A0ZSE6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Cell cycle control protein 50C;
DE   AltName: Full=Transmembrane protein 30C;
GN   Name=TMEM30CP {ECO:0000312|HGNC:HGNC:30443}; Synonyms=CDC50C, TMEM30C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 47-113, AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=17258408; DOI=10.1016/j.gene.2006.11.021;
RA   Osada N., Hashimoto K., Hirai M., Kusuda J.;
RT   "Aberrant termination of reproduction-related TMEM30C transcripts in the
RT   hominoids.";
RL   Gene 392:151-156(2007).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=15375526;
RA   Katoh Y., Katoh M.;
RT   "Identification and characterization of CDC50A, CDC50B and CDC50C genes in
RT   silico.";
RL   Oncol. Rep. 12:939-943(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC       {ECO:0000269|PubMed:17258408}.
CC   -!- SIMILARITY: Belongs to the CDC50/LEM3 family. {ECO:0000305}.
CC   -!- CAUTION: According to PubMed:17258408, the major transcript has no
CC       stop-codon and is probably non protein-coding. A minor transcript is
CC       also expressed and encodes the displayed protein which misses C-
CC       terminal part compared to other mammalian orthologs. {ECO:0000305}.
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DR   EMBL; AC129803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB250297; BAF41210.1; -; mRNA.
DR   AlphaFoldDB; A0ZSE6; -.
DR   SMR; A0ZSE6; -.
DR   STRING; 9606.ENSP00000419663; -.
DR   GlyGen; A0ZSE6; 1 site.
DR   BioMuta; HGNC:30443; -.
DR   PaxDb; A0ZSE6; -.
DR   PRIDE; A0ZSE6; -.
DR   GeneCards; TMEM30CP; -.
DR   HGNC; HGNC:30443; TMEM30CP.
DR   MIM; 611030; gene.
DR   neXtProt; NX_A0ZSE6; -.
DR   eggNOG; KOG2952; Eukaryota.
DR   InParanoid; A0ZSE6; -.
DR   PhylomeDB; A0ZSE6; -.
DR   Pharos; A0ZSE6; Tdark.
DR   PRO; PR:A0ZSE6; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A0ZSE6; protein.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR   InterPro; IPR005045; CDC50/LEM3_fam.
DR   InterPro; IPR030353; TMEM30C.
DR   PANTHER; PTHR10926; PTHR10926; 1.
DR   PANTHER; PTHR10926:SF54; PTHR10926:SF54; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..113
FT                   /note="Cell cycle control protein 50C"
FT                   /id="PRO_0000292845"
FT   TOPO_DOM        1..34
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   113 AA;  13039 MW;  E2526360CFFDF5E1 CRC64;
     MEERAQHCLS RLLDNSALKQ QELPIHRLYF TARRVLFVFF ATGIFCLCMG IILILSARST
     QEIEINYTRI CANCAKLREN ASNFDKECTC SIPFYLSGKM MVGEIQETRL TLH