ZN345_HUMAN
ID ZN345_HUMAN Reviewed; 488 AA.
AC Q14585;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=Zinc finger protein 345;
DE AltName: Full=Zinc finger protein HZF10;
GN Name=ZNF345;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7865130; DOI=10.1089/dna.1995.14.125;
RA Abrink M., Aveskogh M., Hellman L.;
RT "Isolation of cDNA clones for 42 different Kruppel-related zinc finger
RT proteins expressed in the human monoblast cell line U-937.";
RL DNA Cell Biol. 14:125-136(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q14585; G5E9A7: DMWD; NbExp=3; IntAct=EBI-2818408, EBI-10976677;
CC Q14585; O95967: EFEMP2; NbExp=3; IntAct=EBI-2818408, EBI-743414;
CC Q14585; P02545: LMNA; NbExp=3; IntAct=EBI-2818408, EBI-351935;
CC Q14585; Q15287: RNPS1; NbExp=3; IntAct=EBI-2818408, EBI-395959;
CC Q14585; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2818408, EBI-5235340;
CC Q14585; Q86WV8: TSC1; NbExp=3; IntAct=EBI-2818408, EBI-12806590;
CC Q14585; P15622-3: ZNF250; NbExp=3; IntAct=EBI-2818408, EBI-10177272;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; X78933; CAA55533.1; -; mRNA.
DR EMBL; BC032863; AAH32863.1; -; mRNA.
DR CCDS; CCDS12497.1; -.
DR PIR; S47072; S47072.
DR RefSeq; NP_001229401.1; NM_001242472.1.
DR RefSeq; NP_001229403.1; NM_001242474.1.
DR RefSeq; NP_001229404.1; NM_001242475.1.
DR RefSeq; NP_001229405.1; NM_001242476.1.
DR RefSeq; NP_003410.1; NM_003419.4.
DR RefSeq; XP_011525006.1; XM_011526704.2.
DR RefSeq; XP_016882057.1; XM_017026568.1.
DR RefSeq; XP_016882058.1; XM_017026569.1.
DR RefSeq; XP_016882059.1; XM_017026570.1.
DR RefSeq; XP_016882060.1; XM_017026571.1.
DR RefSeq; XP_016882061.1; XM_017026572.1.
DR RefSeq; XP_016882062.1; XM_017026573.1.
DR AlphaFoldDB; Q14585; -.
DR SMR; Q14585; -.
DR BioGRID; 117374; 6.
DR IntAct; Q14585; 8.
DR STRING; 9606.ENSP00000431202; -.
DR iPTMnet; Q14585; -.
DR PhosphoSitePlus; Q14585; -.
DR BioMuta; ZNF345; -.
DR DMDM; 11136080; -.
DR jPOST; Q14585; -.
DR MassIVE; Q14585; -.
DR MaxQB; Q14585; -.
DR PaxDb; Q14585; -.
DR PeptideAtlas; Q14585; -.
DR PRIDE; Q14585; -.
DR ProteomicsDB; 60058; -.
DR Antibodypedia; 47728; 87 antibodies from 13 providers.
DR DNASU; 25850; -.
DR Ensembl; ENST00000420450.6; ENSP00000431216.1; ENSG00000251247.12.
DR Ensembl; ENST00000529555.1; ENSP00000431202.1; ENSG00000251247.12.
DR Ensembl; ENST00000589046.1; ENSP00000465431.1; ENSG00000251247.12.
DR Ensembl; ENST00000612719.4; ENSP00000482400.1; ENSG00000251247.12.
DR Ensembl; ENST00000614069.4; ENSP00000477522.1; ENSG00000251247.12.
DR GeneID; 25850; -.
DR KEGG; hsa:25850; -.
DR MANE-Select; ENST00000420450.6; ENSP00000431216.1; NM_001242472.2; NP_001229401.1.
DR UCSC; uc002oex.4; human.
DR CTD; 25850; -.
DR GeneCards; ZNF345; -.
DR HGNC; HGNC:16367; ZNF345.
DR HPA; ENSG00000251247; Low tissue specificity.
DR neXtProt; NX_Q14585; -.
DR OpenTargets; ENSG00000251247; -.
DR PharmGKB; PA38128; -.
DR VEuPathDB; HostDB:ENSG00000251247; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163308; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q14585; -.
DR OMA; CELETMN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q14585; -.
DR PathwayCommons; Q14585; -.
DR SignaLink; Q14585; -.
DR BioGRID-ORCS; 25850; 17 hits in 1083 CRISPR screens.
DR ChiTaRS; ZNF345; human.
DR GenomeRNAi; 25850; -.
DR Pharos; Q14585; Tdark.
DR PRO; PR:Q14585; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q14585; protein.
DR Bgee; ENSG00000251247; Expressed in right testis and 116 other tissues.
DR ExpressionAtlas; Q14585; baseline and differential.
DR Genevisible; Q14585; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; TAS:ProtInc.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; TAS:ProtInc.
DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR GO; GO:0006383; P:transcription by RNA polymerase III; TAS:ProtInc.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..488
FT /note="Zinc finger protein 345"
FT /id="PRO_0000047544"
FT ZN_FING 62..84
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 90..112
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 118..140
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 146..168
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 174..196
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 202..224
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..252
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..308
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 426..448
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..476
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 488 AA; 55383 MW; 0BDC436E4451285B CRC64;
MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI QHQRIHTDEK
LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG SGANLAYHQR IHTGEKPFEC
KECGKAFGSG SNLTHHQRIH TGEKPYECKE CGKAFSFGSG LIRHQIIHSG EKPYECKECG
KSFSFESALI RHHRIHTGEK PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS
SGSALTRHQR IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD
LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT FSSGSDLTQH
HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC KECGKSFSSG SALNRHQRIH
TGEKPYECKE CGKAFYSGSS LTQHQRIHTG EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK
LCELETIN
