ID   ZN346_XENTR             Reviewed;         354 AA.
AC   B0JZ85;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Zinc finger protein 346 {ECO:0000250|UniProtKB:Q9R0B7};
DE   AltName: Full=Just another zinc finger protein {ECO:0000250|UniProtKB:Q9R0B7};
DE            Short=Protein jaz;
GN   Name=znf346 {ECO:0000250|UniProtKB:Q9R0B7};
GN   Synonyms=jaz {ECO:0000250|UniProtKB:Q8AVN9};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI59077.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAI59077.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds preferentially to dsRNA, but also to RNA-DNA hybrids.
CC       {ECO:0000250|UniProtKB:Q8AVN9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8AVN9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8AVN9}. Note=Primarily nuclear.
CC       {ECO:0000250|UniProtKB:Q8AVN9}.
CC   -!- DOMAIN: The zinc-finger domains are required for binding to dsRNA, and
CC       also for nuclear localization. {ECO:0000250|UniProtKB:Q9R0B7}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI59077.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC159076; AAI59077.1; ALT_INIT; mRNA.
DR   RefSeq; XP_002936996.2; XM_002936950.2.
DR   AlphaFoldDB; B0JZ85; -.
DR   SMR; B0JZ85; -.
DR   Ensembl; ENSXETT00000056332; ENSXETP00000056332; ENSXETG00000007230.
DR   GeneID; 100135716; -.
DR   KEGG; xtr:100135716; -.
DR   CTD; 23567; -.
DR   Xenbase; XB-GENE-967544; znf346.
DR   eggNOG; ENOG502RVNK; Eukaryota.
DR   InParanoid; B0JZ85; -.
DR   OrthoDB; 1565630at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000007230; Expressed in egg cell and 16 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003725; F:double-stranded RNA binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SMART; SM00451; ZnF_U1; 4.
DR   SUPFAM; SSF57667; SSF57667; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..354
FT                   /note="Zinc finger protein 346"
FT                   /id="PRO_0000348935"
FT   ZN_FING         34..64
FT                   /note="Matrin-type 1"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         95..125
FT                   /note="Matrin-type 2"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         165..195
FT                   /note="Matrin-type 3"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         232..262
FT                   /note="Matrin-type 4"
FT                   /evidence="ECO:0000255"
FT   REGION          263..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..334
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         36
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         39
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         52
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         58
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         100
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         113
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
FT   BINDING         119
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q8AVN9"
SQ   SEQUENCE   354 AA;  37823 MW;  52781FC8C79DF223 CRC64;
     MADEFGDGDT VELPVGKEAV DALIRENSHI FSDTQCKVCS AVLISESQKL AHYQSRKHAN
     KVRRYMSIHQ GEEFVSAKKF KAAPAESSDG DDRSKCCPIC NMTFSSPVVA ESHYSGKTHI
     KNLRLREQGG VTEGMLHQAK KLVVTRTPTI ATKIDNRMDQ SDPTKFCKLC HATFNNPLMA
     EQHYAGKKHK KQETKTQLMT IYTSSGHTPA QAPIAINVNS PLPGSGSAGK GFSCDTCNIV
     LNSIEQYQAH VSGAKHKNQL MSMTPLSKEG PPAAGGPSAL AGPPSTGGAL SSGGPSARGF
     SASGGPTPKG PSSFGGLPPM GGLMPPPYPP PHSQPYVRED MMGPDGYTYF NKDF