ID   ZN350_BOVIN             Reviewed;         509 AA.
AC   Q0VCB0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Zinc finger protein 350;
GN   Name=ZNF350;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Binds to a specific sequence, 5'-
CC       GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with BRCA1. Interacts with RNF11. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Note=Associated with the nuclear matrix. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC120263; AAI20264.1; -; mRNA.
DR   RefSeq; NP_001069176.1; NM_001075708.2.
DR   AlphaFoldDB; Q0VCB0; -.
DR   SMR; Q0VCB0; -.
DR   STRING; 9913.ENSBTAP00000017478; -.
DR   PaxDb; Q0VCB0; -.
DR   PRIDE; Q0VCB0; -.
DR   GeneID; 515334; -.
DR   KEGG; bta:515334; -.
DR   CTD; 59348; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q0VCB0; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 8.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..509
FT                   /note="Zinc finger protein 350"
FT                   /id="PRO_0000284054"
FT   DOMAIN          8..78
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         194..216
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         222..244
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         250..272
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         278..300
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         306..328
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         334..356
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         362..384
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         390..412
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   509 AA;  57586 MW;  E51F502A61F61801 CRC64;
     MIQAQETLTF DDVAVDFTWE EWQLLAPAQK ALYRDVMLEN YSNLVSAGFQ ASTPEVLSKL
     DQGEPWMMDD EIHCRTHSEV WKVDGHLLEH LQKKRVEKRL EQWLEQNPLD NSGHQSRALF
     RHNHDVFDLH GRSVTSNSSL LSESLNCEIK RAAEPPADGK SCPYADREPF HPELLSTKSQ
     LMEHQHTKQM KKSHVCSECG KAFVKKSWLA DHQNLHTGEK PHRCNLCGKA FFRKFQLTEH
     QRMHMGDKPY ECTDCGKTFL KKSGLNVHQR THTGEKPFIC SECGKGFIQK GNLVVHLRIH
     TGEKPYTCTE CGKGFTQKTC LMAHQRIHTG TSPFVCGECG KTLSQKMGLI KHQRTHTGEK
     PFECSHCGKG FIEKPQLVIH QRIHTGEKPY RCSKCGKSFR GKSVLNKHLK THSVKKLPPS
     VKSPQSSVVL QEKNLNTVTM HLPPLAPQLP VGISGLLANR STVLVGQPVT RWLPTGDNRG
     LAQERTLMNS VNVVVPSVVN YILFYVTGN