CC50C_MACFA
ID CC50C_MACFA Reviewed; 344 AA.
AC Q95JK4; Q95JU6;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Cell cycle control protein 50C;
DE AltName: Full=Transmembrane protein 30C;
GN Name=TMEM30C; Synonyms=CDC50C; ORFNames=QtsA-12626, QtsA-16374;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=17258408; DOI=10.1016/j.gene.2006.11.021;
RA Osada N., Hashimoto K., Hirai M., Kusuda J.;
RT "Aberrant termination of reproduction-related TMEM30C transcripts in the
RT hominoids.";
RL Gene 392:151-156(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q95JK4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95JK4-2; Sequence=VSP_026449, VSP_026450;
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC {ECO:0000269|PubMed:17258408}.
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family. {ECO:0000305}.
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DR EMBL; AB070082; BAB63027.1; -; mRNA.
DR EMBL; AB070177; BAB63122.1; -; mRNA.
DR AlphaFoldDB; Q95JK4; -.
DR SMR; Q95JK4; -.
DR STRING; 9541.XP_005548379.1; -.
DR PRIDE; Q95JK4; -.
DR eggNOG; KOG2952; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0033036; P:macromolecule localization; IEA:UniProt.
DR InterPro; IPR005045; CDC50/LEM3_fam.
DR InterPro; IPR030353; TMEM30C.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR PANTHER; PTHR10926:SF1; PTHR10926:SF1; 1.
DR Pfam; PF03381; CDC50; 1.
DR PIRSF; PIRSF015840; DUF284_TM_euk; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..344
FT /note="Cell cycle control protein 50C"
FT /id="PRO_0000292846"
FT TOPO_DOM 1..34
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..344
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 282..292
FT /note="NFPVTRFQGEK -> SILSYHFSFWR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_026449"
FT VAR_SEQ 293..344
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_026450"
SQ SEQUENCE 344 AA; 39512 MW; 197EB37B204BCEB3 CRC64;
MEETPQHCLS RLPDNSALKQ QELPAHRLYF TARRVLFVFF TTGIFCLCMG IILILSARST
QEIEINYTRI CANCAKLREN ASNFDKECTC SIPFYLSGKM MGNVYMYYKL YGFYQNLYRY
VRSRSNRQLV GKDVKAVEDC APFKMSDNKT PIVPCGAIAN SMFNDTIILS HNINSSVQIK
VPMLKSGLTW WTDKYVKFQN PSSKNLADEF RGTTKPPNWP KPIYDLDKKD PRNNGFLNDD
FIVWMRAAAF PTFKKLYGRL NRTHHFIEGL PAGNYSFNIT YNFPVTRFQG EKSVVLSTLT
WCGGNSLFLG LAYTVTGAIT WLASFTMMAI HITLKNKQMS FFHQ
