ZN358_HUMAN
ID ZN358_HUMAN Reviewed; 568 AA.
AC Q9NW07; Q9BTM7;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Zinc finger protein 358;
GN Name=ZNF358;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-568.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH14002.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA91582.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC008878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003585; AAH03585.1; -; mRNA.
DR EMBL; BC014002; AAH14002.1; ALT_INIT; mRNA.
DR EMBL; CX782162; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK001252; BAA91582.1; ALT_INIT; mRNA.
DR CCDS; CCDS32890.2; -.
DR RefSeq; NP_060553.4; NM_018083.4.
DR RefSeq; XP_005272517.1; XM_005272460.3.
DR RefSeq; XP_011525997.1; XM_011527695.1.
DR AlphaFoldDB; Q9NW07; -.
DR SMR; Q9NW07; -.
DR BioGRID; 126619; 16.
DR IntAct; Q9NW07; 4.
DR STRING; 9606.ENSP00000472305; -.
DR iPTMnet; Q9NW07; -.
DR PhosphoSitePlus; Q9NW07; -.
DR BioMuta; ZNF358; -.
DR DMDM; 251757418; -.
DR EPD; Q9NW07; -.
DR jPOST; Q9NW07; -.
DR MassIVE; Q9NW07; -.
DR MaxQB; Q9NW07; -.
DR PaxDb; Q9NW07; -.
DR PeptideAtlas; Q9NW07; -.
DR PRIDE; Q9NW07; -.
DR ProteomicsDB; 82884; -.
DR Antibodypedia; 12050; 125 antibodies from 19 providers.
DR DNASU; 140467; -.
DR Ensembl; ENST00000597229.2; ENSP00000472305.1; ENSG00000198816.7.
DR GeneID; 140467; -.
DR KEGG; hsa:140467; -.
DR MANE-Select; ENST00000597229.2; ENSP00000472305.1; NM_018083.5; NP_060553.4.
DR UCSC; uc002mgn.3; human.
DR CTD; 140467; -.
DR DisGeNET; 140467; -.
DR GeneCards; ZNF358; -.
DR HGNC; HGNC:16838; ZNF358.
DR HPA; ENSG00000198816; Low tissue specificity.
DR MIM; 619496; gene.
DR neXtProt; NX_Q9NW07; -.
DR OpenTargets; ENSG00000198816; -.
DR PharmGKB; PA38189; -.
DR VEuPathDB; HostDB:ENSG00000198816; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162948; -.
DR HOGENOM; CLU_025444_0_0_1; -.
DR InParanoid; Q9NW07; -.
DR OMA; EDVDPNY; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9NW07; -.
DR TreeFam; TF350840; -.
DR PathwayCommons; Q9NW07; -.
DR SignaLink; Q9NW07; -.
DR BioGRID-ORCS; 140467; 13 hits in 1103 CRISPR screens.
DR ChiTaRS; ZNF358; human.
DR GenomeRNAi; 140467; -.
DR Pharos; Q9NW07; Tdark.
DR PRO; PR:Q9NW07; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NW07; protein.
DR Bgee; ENSG00000198816; Expressed in apex of heart and 159 other tissues.
DR ExpressionAtlas; Q9NW07; baseline and differential.
DR Genevisible; Q9NW07; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISS:UniProtKB.
DR GO; GO:0021915; P:neural tube development; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0019827; P:stem cell population maintenance; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..568
FT /note="Zinc finger protein 358"
FT /id="PRO_0000047547"
FT ZN_FING 151..173
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 179..201
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..229
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..79
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..485
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 32
FT /note="N -> S (in dbSNP:rs11555037)"
FT /id="VAR_061944"
FT CONFLICT 242
FT /note="K -> Q (in Ref. 2; CX782162)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 568 AA; 59287 MW; 347131478D2A5FF8 CRC64;
MRRSVLVRNP GHKGLRPVYE ELDSDSEDLD PNPEDLDPVS EDPEPDPEDL NTVPEDVDPS
YEDLEPVSED LDPDAEAPGS EPQDPDPMSS SFDLDPDVIG PVPLILDPNS DTLSPGDPKV
DPISSGLTAT PQVLATSPAV LPAPASPPRP FSCPDCGRAF RRSSGLSQHR RTHSGEKPYR
CPDCGKSFSH GATLAQHRGI HTGARPYQCA ACGKAFGWRS TLLKHRSSHS GEKPHHCPVC
GKAFGHGSLL AQHLRTHGGP RPHKCPVCAK GFGQGSALLK HLRTHTGERP YPCPQCGKAF
GQSSALLQHQ RTHTAERPYR CPHCGKAFGQ SSNLQHHLRI HTGERPYACP HCSKAFGQSS
ALLQHLHVHS GERPYRCQLC GKAFGQASSL TKHKRVHEGA AAAAAAAAAA AAAAAAGLGL
GPGLSPASMM RPGQVSLLGP DAVSVLGSGL GLSPGTSSGR NPDPGSGPGT LPDPSSKPLP
GSRSTPSPTP VESSDPKAGH DAGPDLVPSP DLDPVPSPDP DPVPSPDPNP VSCPDPCSPT
RGTVSPALPT GESPEWVQEQ GALLGPDG
