ZN366_HUMAN
ID ZN366_HUMAN Reviewed; 744 AA.
AC Q8N895; Q5HYI9; Q7RTV4;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein 366 {ECO:0000303|PubMed:12234665};
DE AltName: Full=Dendritic cell-specific transcript protein {ECO:0000303|PubMed:16393996};
DE Short=DC-SCRIPT {ECO:0000303|PubMed:16393996};
GN Name=ZNF366 {ECO:0000303|PubMed:12234665};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=12234665; DOI=10.1016/s0378-1119(02)00793-x;
RA Gilligan P., Brenner S., Venkatesh B.;
RT "Fugu and human sequence comparison identifies novel human genes and
RT conserved non-coding sequences.";
RL Gene 294:35-44(2002).
RN [6]
RP INTERACTION WITH CTBP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MOTIF,
RP AND MUTAGENESIS OF LEU-593 AND LEU-648.
RX PubMed=16393996; DOI=10.4049/jimmunol.176.2.1081;
RA Triantis V., Trancikova D.E., Looman M.W., Hartgers F.C., Janssen R.A.,
RA Adema G.J.;
RT "Identification and characterization of DC-SCRIPT, a novel dendritic cell-
RT expressed member of the zinc finger family of transcriptional regulators.";
RL J. Immunol. 176:1081-1089(2006).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ESR1; NRIP1 AND CTBP1,
RP MOTIF, AND MUTAGENESIS OF PRO-590; ASP-592; PRO-645 AND ASP-647.
RX PubMed=17085477; DOI=10.1093/nar/gkl875;
RA Lopez-Garcia J., Periyasamy M., Thomas R.S., Christian M., Leao M., Jat P.,
RA Kindle K.B., Heery D.M., Parker M.G., Buluwela L., Kamalati T., Ali S.;
RT "ZNF366 is an estrogen receptor corepressor that acts through CtBP and
RT histone deacetylases.";
RL Nucleic Acids Res. 34:6126-6136(2006).
CC -!- FUNCTION: Has transcriptional repression activity. Acts as corepressor
CC of ESR1; the function seems to involve CTBP1 and histone deacetylases.
CC {ECO:0000269|PubMed:17085477}.
CC -!- SUBUNIT: Interacts with ESR1 and NRIP1 (PubMed:17085477). Interacts
CC (via PXDLS motif) with CTBP1 (PubMed:16393996, PubMed:17085477).
CC {ECO:0000269|PubMed:16393996, ECO:0000269|PubMed:17085477}.
CC -!- INTERACTION:
CC Q8N895; P01023: A2M; NbExp=3; IntAct=EBI-2813661, EBI-640741;
CC Q8N895; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-2813661, EBI-357530;
CC Q8N895; Q92870-2: APBB2; NbExp=3; IntAct=EBI-2813661, EBI-21535880;
CC Q8N895; P05067: APP; NbExp=3; IntAct=EBI-2813661, EBI-77613;
CC Q8N895; P54253: ATXN1; NbExp=6; IntAct=EBI-2813661, EBI-930964;
CC Q8N895; P54252: ATXN3; NbExp=3; IntAct=EBI-2813661, EBI-946046;
CC Q8N895; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-2813661, EBI-3866279;
CC Q8N895; Q8NHQ1: CEP70; NbExp=8; IntAct=EBI-2813661, EBI-739624;
CC Q8N895; Q13363: CTBP1; NbExp=5; IntAct=EBI-2813661, EBI-908846;
CC Q8N895; G5E9A7: DMWD; NbExp=3; IntAct=EBI-2813661, EBI-10976677;
CC Q8N895; P50570-2: DNM2; NbExp=3; IntAct=EBI-2813661, EBI-10968534;
CC Q8N895; P03372: ESR1; NbExp=6; IntAct=EBI-2813661, EBI-78473;
CC Q8N895; Q53GS7: GLE1; NbExp=3; IntAct=EBI-2813661, EBI-1955541;
CC Q8N895; P28799: GRN; NbExp=3; IntAct=EBI-2813661, EBI-747754;
CC Q8N895; P28799-2: GRN; NbExp=3; IntAct=EBI-2813661, EBI-25860013;
CC Q8N895; P42858: HTT; NbExp=15; IntAct=EBI-2813661, EBI-466029;
CC Q8N895; O60333-2: KIF1B; NbExp=3; IntAct=EBI-2813661, EBI-10975473;
CC Q8N895; P48552: NRIP1; NbExp=2; IntAct=EBI-2813661, EBI-746484;
CC Q8N895; O43933: PEX1; NbExp=3; IntAct=EBI-2813661, EBI-988601;
CC Q8N895; Q9BXM7: PINK1; NbExp=3; IntAct=EBI-2813661, EBI-2846068;
CC Q8N895; P60891: PRPS1; NbExp=3; IntAct=EBI-2813661, EBI-749195;
CC Q8N895; P49810: PSEN2; NbExp=3; IntAct=EBI-2813661, EBI-2010251;
CC Q8N895; P25788: PSMA3; NbExp=5; IntAct=EBI-2813661, EBI-348380;
CC Q8N895; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-2813661, EBI-396669;
CC Q8N895; P37840: SNCA; NbExp=3; IntAct=EBI-2813661, EBI-985879;
CC Q8N895; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-2813661, EBI-5235340;
CC Q8N895; Q13148: TARDBP; NbExp=4; IntAct=EBI-2813661, EBI-372899;
CC Q8N895; Q86WV8: TSC1; NbExp=3; IntAct=EBI-2813661, EBI-12806590;
CC Q8N895; O76024: WFS1; NbExp=3; IntAct=EBI-2813661, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16393996,
CC ECO:0000269|PubMed:17085477}.
CC -!- TISSUE SPECIFICITY: Expressed in immature and mature dendritic cells
CC (DCs). Not detected in other blood cell types.
CC {ECO:0000269|PubMed:16393996}.
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DR EMBL; AK097115; BAC04954.1; -; mRNA.
DR EMBL; BX647592; CAI46096.1; -; mRNA.
DR EMBL; CH471084; EAW95707.1; -; Genomic_DNA.
DR EMBL; BC121053; AAI21054.1; -; mRNA.
DR EMBL; BK000210; DAA00066.1; -; mRNA.
DR CCDS; CCDS4015.1; -.
DR RefSeq; NP_689838.1; NM_152625.2.
DR AlphaFoldDB; Q8N895; -.
DR SMR; Q8N895; -.
DR BioGRID; 127947; 9.
DR IntAct; Q8N895; 32.
DR STRING; 9606.ENSP00000313158; -.
DR iPTMnet; Q8N895; -.
DR PhosphoSitePlus; Q8N895; -.
DR BioMuta; ZNF366; -.
DR DMDM; 28380235; -.
DR jPOST; Q8N895; -.
DR MassIVE; Q8N895; -.
DR PaxDb; Q8N895; -.
DR PeptideAtlas; Q8N895; -.
DR PRIDE; Q8N895; -.
DR ProteomicsDB; 72385; -.
DR Antibodypedia; 12194; 145 antibodies from 28 providers.
DR DNASU; 167465; -.
DR Ensembl; ENST00000318442.6; ENSP00000313158.5; ENSG00000178175.12.
DR GeneID; 167465; -.
DR KEGG; hsa:167465; -.
DR MANE-Select; ENST00000318442.6; ENSP00000313158.5; NM_152625.3; NP_689838.1.
DR UCSC; uc003kce.2; human.
DR CTD; 167465; -.
DR DisGeNET; 167465; -.
DR GeneCards; ZNF366; -.
DR HGNC; HGNC:18316; ZNF366.
DR HPA; ENSG00000178175; Low tissue specificity.
DR MIM; 610159; gene.
DR neXtProt; NX_Q8N895; -.
DR OpenTargets; ENSG00000178175; -.
DR PharmGKB; PA38314; -.
DR VEuPathDB; HostDB:ENSG00000178175; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155498; -.
DR HOGENOM; CLU_019459_2_1_1; -.
DR InParanoid; Q8N895; -.
DR OMA; KRWQCPM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N895; -.
DR TreeFam; TF331510; -.
DR PathwayCommons; Q8N895; -.
DR SignaLink; Q8N895; -.
DR BioGRID-ORCS; 167465; 8 hits in 1091 CRISPR screens.
DR ChiTaRS; ZNF366; human.
DR GeneWiki; ZNF366; -.
DR GenomeRNAi; 167465; -.
DR Pharos; Q8N895; Tbio.
DR PRO; PR:Q8N895; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8N895; protein.
DR Bgee; ENSG00000178175; Expressed in sural nerve and 98 other tissues.
DR ExpressionAtlas; Q8N895; baseline and differential.
DR Genevisible; Q8N895; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IDA:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
DR GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043627; P:response to estrogen; IDA:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..744
FT /note="Zinc finger protein 366"
FT /id="PRO_0000047548"
FT ZN_FING 253..275
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..556
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 206..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..744
FT /note="Interaction with NRIP1"
FT /evidence="ECO:0000269|PubMed:17085477"
FT REGION 603..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 590..594
FT /note="PXDLS"
FT /evidence="ECO:0000269|PubMed:16393996,
FT ECO:0000269|PubMed:17085477"
FT VARIANT 739
FT /note="A -> G (in dbSNP:rs13188519)"
FT /id="VAR_033564"
FT MUTAGEN 590
FT /note="P->A: Abolishes interaction with CTBP1 and in part
FT relieves transcription repression; when associated with A-
FT 592."
FT /evidence="ECO:0000269|PubMed:17085477"
FT MUTAGEN 592
FT /note="D->A: Abolishes interaction with CTBP1 and in part
FT relieves transcription repression; when associated with A-
FT 590."
FT /evidence="ECO:0000269|PubMed:17085477"
FT MUTAGEN 593
FT /note="L->A: Abolishes interaction with CTBP1. Abolishes
FT interaction with CTBP1; when associated with A-648."
FT /evidence="ECO:0000269|PubMed:16393996"
FT MUTAGEN 645
FT /note="P->A: Decreases interaction with CTBP1; when
FT associated with A-647."
FT /evidence="ECO:0000269|PubMed:17085477"
FT MUTAGEN 647
FT /note="D->A: Decreases interaction with CTBP1; when
FT associated with A-645."
FT /evidence="ECO:0000269|PubMed:17085477"
FT MUTAGEN 648
FT /note="L->A: No effect on interaction with CTBP1. Abolishes
FT interaction with CTBP1; when associated with A-593."
FT /evidence="ECO:0000269|PubMed:16393996"
SQ SEQUENCE 744 AA; 85107 MW; D4E12259280727B1 CRC64;
MQKEMKMIKD EDVHFDLAVK KTPSFPHCLQ PVASRGKAPQ RHPFPEALRG PFSQFRYEPP
PGDLDGFPGV FEGAGSRKRK SMPTKMPYNH PAEEVTLALH SEENKNHGLP NLPLLFPQPP
RPKYDSQMID LCNVGFQFYR SLEHFGGKPV KQEPIKPSAV WPQPTPTPFL PTPYPYYPKV
HPGLMFPFFV PSSSPFPFSR HTFLPKQPPE PLLPRKAEPQ ESEETKQKVE RVDVNVQIDD
SYYVDVGGSQ KRWQCPTCEK SYTSKYNLVT HILGHSGIKP HACTHCGKLF KQLSHLHTHM
LTHQGTRPHK CQVCHKAFTQ TSHLKRHMMQ HSEVKPHNCR VCGRGFAYPS ELKAHEAKHA
SGRENICVEC GLDFPTLAQL KRHLTTHRGP IQYNCSECDK TFQYPSQLQN HMMKHKDIRP
YICSECGMEF VQPHHLKQHS LTHKGVKEHK CGICGREFTL LANMKRHVLI HTNIRAYQCH
LCYKSFVQKQ TLKAHMIVHS DVKPFKCKLC GKEFNRMHNL MGHMHLHSDS KPFKCLYCPS
KFTLKGNLTR HMKVKHGVME RGLHSQGLGR GRIALAQTAG VLRSLEQEEP FDLSQKRRAK
VPVFQSDGES AQGSHCHEEE EEDNCYEVEP YSPGLAPQSQ QLCTPEDLST KSEHAPEVLE
EACKEEKEDA SKGEWEKRSK GDLGAEGGQE RDCAGRDECL SLRAFQSTRR GPSFSDYLYF
KHRDESLKEL LERKMEKQAV LLGI
