CC50C_MOUSE
ID CC50C_MOUSE Reviewed; 342 AA.
AC Q9D4D7; A9C447;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Cell cycle control protein 50C;
DE AltName: Full=Transmembrane protein 30C;
GN Name=Tmem30c; Synonyms=Cdc50c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=17258408; DOI=10.1016/j.gene.2006.11.021;
RA Osada N., Hashimoto K., Hirai M., Kusuda J.;
RT "Aberrant termination of reproduction-related TMEM30C transcripts in the
RT hominoids.";
RL Gene 392:151-156(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC {ECO:0000269|PubMed:17258408}.
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family. {ECO:0000305}.
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DR EMBL; AK016597; BAB30332.1; -; mRNA.
DR EMBL; CT025521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466521; EDK98171.1; -; Genomic_DNA.
DR CCDS; CCDS49876.1; -.
DR RefSeq; NP_081927.1; NM_027651.1.
DR RefSeq; XP_011244314.1; XM_011246012.2.
DR RefSeq; XP_011244316.1; XM_011246014.2.
DR RefSeq; XP_017172622.1; XM_017317133.1.
DR AlphaFoldDB; Q9D4D7; -.
DR SMR; Q9D4D7; -.
DR STRING; 10090.ENSMUSP00000023434; -.
DR GlyGen; Q9D4D7; 4 sites.
DR PaxDb; Q9D4D7; -.
DR PRIDE; Q9D4D7; -.
DR ProteomicsDB; 283721; -.
DR DNASU; 71027; -.
DR Ensembl; ENSMUST00000023434; ENSMUSP00000023434; ENSMUSG00000022753.
DR Ensembl; ENSMUST00000119407; ENSMUSP00000112989; ENSMUSG00000022753.
DR GeneID; 71027; -.
DR KEGG; mmu:71027; -.
DR UCSC; uc007zne.2; mouse.
DR CTD; 71027; -.
DR MGI; MGI:1918277; Tmem30c.
DR VEuPathDB; HostDB:ENSMUSG00000022753; -.
DR eggNOG; KOG2952; Eukaryota.
DR GeneTree; ENSGT00390000004660; -.
DR InParanoid; Q9D4D7; -.
DR OMA; TARPPYW; -.
DR OrthoDB; 889671at2759; -.
DR PhylomeDB; Q9D4D7; -.
DR TreeFam; TF300873; -.
DR BioGRID-ORCS; 71027; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem30c; mouse.
DR PRO; PR:Q9D4D7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9D4D7; protein.
DR Bgee; ENSMUSG00000022753; Expressed in spermatocyte and 24 other tissues.
DR ExpressionAtlas; Q9D4D7; baseline and differential.
DR Genevisible; Q9D4D7; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR InterPro; IPR005045; CDC50/LEM3_fam.
DR InterPro; IPR030353; TMEM30C.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR PANTHER; PTHR10926:SF1; PTHR10926:SF1; 1.
DR Pfam; PF03381; CDC50; 1.
DR PIRSF; PIRSF015840; DUF284_TM_euk; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="Cell cycle control protein 50C"
FT /id="PRO_0000292847"
FT TOPO_DOM 1..33
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 90
FT /note="C -> Y (in Ref. 1; BAB30332)"
FT /evidence="ECO:0000305"
FT CONFLICT 232
FT /note="G -> E (in Ref. 1; BAB30332)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="G -> A (in Ref. 1; BAB30332)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="K -> T (in Ref. 1; BAB30332)"
FT /evidence="ECO:0000305"
FT CONFLICT 290
FT /note="G -> E (in Ref. 1; BAB30332)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 38604 MW; D492047E002C8366 CRC64;
MEMMPQYDLS RLPENTALKQ QTLPTQQLNL SASVVLSIFF ITGGFCLSIG IILLLSAKST
KKIEINYTKT CANCAQLREN SSNFDKACNC SLPFYLPEKM EGDVYMYYKL YGFYQNLYQY
ILSRSNSQLV GKDIWDTTNC DPFQVSHNDT PIIPCGAIAN SIFNDTITLS YNLNSSTQIE
VPMLKSGLTW WTDKYVKFRN PRSSNFTSTF AGSSKPLHWA KPIYELDLDD PGNNGFLNED
FIVWMRTAAF PTFKKLYRRL KRVHAFAEGL PAGNYSLSIS YNFPVTMFQG EKSIVLSTLT
WIGGGGLFLG LTYTVTGALT LLASFAILTI HLMLKRSKLN FL
